NCT00432029|Completed
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Sponsor study identifier
interventional
80
1 country
1
Study Start
December 2006
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2007
Actual (reported)Study Completion
January 2008
Actual (reported)A couple of studies have shown that illuminating the eye with diffuse flickering light is accompanied by an increase of retinal vessel diameters, optic nerve head blood flow and retinal blood flow. We have recently used this visual stimulation technique as a new and powerful tool for the non-invasive investigation of vascular reactivity. Additionally, we could show that this response is diminished in patients with vascular pathologies and that the response is dependent on nitric oxide, indicating that flicker induced vasodilatation may reflect endothelial dysfunction and may be a new approach to test endothelial function in vivo. One of the most widely used method for the assessment of endothelial function is flow mediated dilatation (FMD). FMD has been shown to give a reliable estimate of vascular function in vivo. In the present study, we set out to compare the standard method for the evaluation of endothelial function, FMD, to flicker induced vasodilatation in the retina.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2008
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 2006
Date type not reportedThis date has not been verified as actual or estimated.
February 5, 2007
Actual (reported)February 6, 2007
Actual (reported)December 2007
Actual (reported)January 2008
Actual (reported)Retinal vessel diameters (Retinal vessel analyzer)
8 min
Forearm Blood Flow
8 min
IDDM
Hypercholesterolemia and/or Hypertension
Forearm blood flow measurement: baseline 1 min, 3 min after inflation of cuff, 4 min after 0.8mg Nitroglycerin
Department of Clinical Pharmacology, Medical University of Vienna
Vienna, 1090, Austria
Pemp B, Garhofer G, Weigert G, Karl K, Resch H, Wolzt M, Schmetterer L. Reduced retinal vessel response to flicker stimulation but not to exogenous nitric oxide in type 1 diabetes. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4029-32. doi: 10.1167/iovs.08-3260. Epub 2009 Apr 15.
Michael Wolzt, MD
Department of Clinical Pharmacology, Medical University of Vienna
80 participants (actual enrollment reported by the registry).
First Submitted
February 5, 2007
First Posted
February 6, 2007
Study Start
December 2006
Date type not reportedThis date has not been verified as actual or estimated.
age/sex matched healthy control subjects
Stimulation with Flicker-light: 1 min, measurement without flickering light 4 min after 0.8 mg Nitroglycerin
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Primary Completion
December 2007
Actual (reported)Study Completion
January 2008
Actual (reported)Last Updated
July 4, 2008
Record last verified: 2008-06
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Source: ClinicalTrials.gov.
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