Imatinib Mesylate and Bevacizumab After First-Line Chemotherapy and Bevacizumab in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer

NCT00425646 | Completed Phase 2

• 5 other identifiers: 6351UWCC-6351UWCC-06-3622-H/BNOVARTIS-UWCC-6351CDR0000526130
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

RATIONALE: Imatinib mesylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Imatinib mesylate and bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving imatinib mesylate together with bevacizumab as maintenance therapy may stop non-small cell lung cancer from growing or coming back. PURPOSE: This phase II trial is studying how well giving imatinib mesylate together with bevacizumab after first-line chemotherapy and bevacizumab works in treating patients with stage IIIB or stage IV non-small cell lung cancer.

Conditions

Lung Cancer

Keywords

stage IIIB non-small cell lung cancer; stage IV non-small cell lung cancer; adenocarcinoma of the lung; bronchoalveolar cell lung cancer; large cell lung cancer; recurrent non-small cell lung cancer

Outcome Measures

Primary Outcomes (1)

• Progression-free survival

Secondary Outcomes (2)

• Overall survival

• Toxicity rate, defined as percentage of patients experiencing a grade 3 or greater adverse event

Interventions

bevacizumab BIOLOGICAL

imatinib mesylate DRUG

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

DISEASE CHARACTERISTICS: * Histologically or cytologically confirmed non-small cell lung cancer * Stage IIIB (by pleural effusion only) or stage IV disease * No predominately squamous cell carcinoma * Mixed tumors will be categorized by predominant cell type * Must have completed 4 courses of platinum-based, doublet chemotherapy and bevacizumab\*, has no disease progression, and meets the following criteria: * Platinum agent may have included carboplatin or cisplatin * Second agent may have included paclitaxel, docetaxel, gemcitabine hydrochloride, vinorelbine ditartrate, or pemetrexed disodium * A change in the platinum doublet is acceptable provided the following are true: * Basis for change was toxicity rather than disease progression * Total number of courses of any platinum doublet plus bevacizumab was 4 * At least 3 of 4 courses must have included bevacizumab NOTE: \*Patients age 70 and over may have completed 4 courses of single-agent chemotherapy plus bevacizumab; single agent chemotherapy may have included paclitaxel, docetaxel, gemcitabine hydrochloride, vinorelbine ditartrate, or pemetrexed disodium * No brain metastases by brain MRI or head CT scan PATIENT CHARACTERISTICS: * ECOG performance status 0-1 * Bilirubin ≤ 1.25 times upper limit of normal (ULN) * AST and ALT ≤ 2.5 times ULN * Creatinine ≤ 1.5 times ULN * Absolute neutrophil count ≥ 1500/mm³ * Platelet count ≥ 100,000/mm³ * INR ≤ 1.5 times ULN * Urine protein:creatinine ratio ≤ 1 * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective barrier contraception during and for 3 months after completion of study treatment * No history of gross hemoptysis (defined as \> ½ teaspoon of bright red blood) * No inadequately controlled hypertension (defined as blood pressure \> 150/100 mm Hg on antihypertensive medications) * No significant traumatic injury within the past 28 days * No condition requiring continuous administration of systemic corticosteroids * No medical condition that would preclude study treatment * No medical comorbidities, including any of the following: * Unstable angina * Congestive heart failure ≥ grade 2 * Myocardial infarction within the past 6 months * Stroke within the past 6 months * Peripheral vascular disease ≥ grade 2 within the past 6 months PRIOR CONCURRENT THERAPY: * See Disease Characteristics * No prior systemic chemotherapy in the metastatic setting, except for 4 courses of platinum-based, doublet chemotherapy plus bevacizumab in the first-line setting * Prior adjuvant, neoadjuvant, or combined modality chemoradiation for localized non-small cell lung cancer allowed provided ≥ 6 months elapsed before metastatic recurrence * At least 28 days since prior major surgical procedure * No prior antiangiogenic drug, including AMG 706, CP-547, 632, vatalanib, AZD2171, thalidomide, sorafenib tosylate, or sunitinib malate * No other concurrent investigational drugs * No concurrent grapefruit juice or products containing grapefruit * No other concurrent anticancer agents, including chemotherapy and biological agents * No concurrent major surgical procedure * No concurrent therapeutic coagulation comprising warfarin, heparin, or low molecular weight heparin * Low-dose warfarin (e.g., 1 mg/day) for prophylaxis of central venous catheter thrombosis allowed * No chronic daily acetylsalicylic acid (\> 325 mg/day) or other full-dose nonsteroidal anti-inflammatory drug with antiplatelet activity

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• University of Washington: lead
• National Cancer Institute (NCI): collaborator

Study Sites (1)

Seattle Cancer Care Alliance

Seattle, Washington, 98109-1023, United States

Location

MeSH Terms

Conditions

Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma of Lung; Adenocarcinoma, Bronchiolo-Alveolar

Interventions

Bevacizumab; Imatinib Mesylate

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Carcinoma, Bronchogenic; Bronchial Neoplasms; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type

Intervention Hierarchy (Ancestors)

Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal; Antibodies; Immunoglobulins; Immunoproteins; Blood Proteins; Proteins; Amino Acids, Peptides, and Proteins; Serum Globulins; Globulins; Benzamides; Amides; Organic Chemicals; Benzoates; Acids, Carbocyclic; Carboxylic Acids; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Piperazines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Pyrimidines

Study Officials

• Laurie Carr, MD

  Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: phase 2
• Masking: NONE
• Purpose: TREATMENT
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 19, 2007
• First Posted: January 23, 2007
• Study Start: November 1, 2006
• Primary Completion: October 1, 2007
• Study Completion: July 1, 2009
• Last Updated: May 6, 2013

Record last verified: 2013-05

Locations

US (1)