Inpatient Influenza Surveillance

NCT00419861 | Completed

• 1 other identifier: 06-0051
• Study Type: observational
• Target: 350
• Locations: 1 country
• Sites: 1

Brief Summary

Influenza vaccination is recommended for all persons age 65 and older. Vaccines that are designed and tested in young healthy adults are often not as effective when used in the elderly. This study will be a one year pilot study to see if it would be practical to conduct a larger study at several other hospitals in the future. Study participants will include 350 men and women greater than or equal to age 50 that are hospitalized at Vanderbilt University or Baptist Community Hospital with acute respiratory symptoms. Study procedures will include questions, one nasal swab, one throat swab, and chart reviews after the patient has been released from the hospital. The nasal and throat swabs will be tested for influenza A and B viruses.

Conditions

Influenza

Keywords

Influenza, surveillance, flu, parent protocol

Study Arms (1)

Group 1

Adults \>/= 50 years of age, hospitalized for respiratory illness in Davidson County, TN.

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Inclusion Criteria: 1. Adults \>/= 50 years of age 2. Resident of Davidson County 3. Admitted to hospital during defined 24 hour periods 4. Patients with one or more of the following admission diagnoses (International Classification of Diseases, 9th Revision Number): pneumonia (480-486), upper respiratory infection (465), bronchitis (466), influenza (487), chronic obstructive pulmonary disease (490 to 492;496), asthma (493), viral illness (079.9)\[13\], dyspnea (786), acute respiratory failure (518.81), pneumonitis due to solids/liquids (507), or fever (780.6) without localizing symptoms. Exclusion Criteria: 1. Adults \>/= 50 years residing outside the surveillance areas 2. Adults \>/= 50 years not admitted on a surveillance day 3. Adults \< 50 years of age 4. Anyone without the above admitting criteria.

You may qualify if:

• Adults greater than or equal to 50 years of age
• Resident of Davidson County
• Admitted to hospital during defined 24 hour periods
• Patients with one or more of the following admission diagnoses: pneumonia, upper respiratory infection, bronchitis, influenza, chronic obstructive pulmonary disease, asthma, viral illness, dyspnea, acute respiratory failure, pneumonitis due to solids/liquids, or fever without localizing symptoms

You may not qualify if:

• Adults greater than or equal to 50 years residing outside the surveillance areas
• Adults greater than or equal to 50 years not admitted on a surveillance day
• Adults \< 50 years of age

Sponsors & Collaborators

• National Institute of Allergy and Infectious Diseases (NIAID): lead

Study Sites (1)

Vanderbilt University

Nashville, Tennessee, 37232, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Nasal and throat swabs will be obtained and combined for viral culture, rapid antigen testing, and PCR. Specimens obtained from hospitalized subjects will be tested for influenza A \& B viruses by viral culture, rapid antigen testing and Real-Time Reverse-Transcriptase PCR (RTrtPCR) analysis.

MeSH Terms

Conditions

Influenza, Human

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Orthomyxoviridae Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH

Study Record Dates

• First Submitted: January 5, 2007
• First Posted: January 9, 2007
• Study Start: November 1, 2006
• Primary Completion: April 1, 2007
• Study Completion: April 1, 2007
• Last Updated: August 23, 2013

Record last verified: 2012-01

Locations

US (1)