Thrombus Aspiration in Myocardial Infarction
TASTE
Thrombus Aspiration in ST- Elevation Myocardial Infarction in Scandinavia
1 other identifier
interventional
7,243
3 countries
29
Brief Summary
Treatment of myocardial infarction (blood clot in the arteries of the heart) has improved after introduction of 24/7 balloon angioplasty to open the blocked artery. However, the clot itself is not routinely removed but recent data in smaller trials indicate that this might improve recovery and prognosis. In this multicenter study of 5000 patients referred to Scandinavian hospitals for myocardial infarction the investigators test the hypothesis that patients randomized to treatment with thrombus aspiration (removing the blood clot by manual suction) before conventional angioplasty will have a reduced risk of death, fewer rehospitalisations, fewer new myocardial infarctions, reduced risk of heart failure, better coronary artery flow after angioplasty and greater reduction of infarct size compared to patients randomized to conventional angioplasty alone.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jul 2010
Typical duration for not_applicable
29 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 22, 2010
CompletedFirst Posted
Study publicly available on registry
March 25, 2010
CompletedStudy Start
First participant enrolled
July 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2013
CompletedJuly 11, 2016
July 1, 2016
2.7 years
March 22, 2010
July 7, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
All-cause death
Death from any cause will be registered via national registries during the first 30 days after study inclusion.
30 days
Secondary Outcomes (6)
Time to re-hospitalization with nonfatal reinfarction, heart failure and target vessel revascularization
30 days to 10 years
Time to all-cause death or new myocardial infarction (first occurring) or in hospital treatment for heart failure
30 days to 10 years
Time to acute coronary occlusion, stent thrombosis and restenosis in treated lesions
1 year
Length of hospital stay
1 month
TIMI-flow grade
3 hours
- +1 more secondary outcomes
Study Arms (2)
Thrombus aspiration
EXPERIMENTALThrombus aspiration is then followed by standard balloon angioplasty (PCI).
Standard balloon angioplasty (PCI)
ACTIVE COMPARATORInterventions
Aspiration of thrombus material before angioplasty
Eligibility Criteria
You may qualify if:
- Patients with a diagnosis of ST-segment elevation myocardial infarction
- Correspondence between ECG findings and culprit artery pathoanatomy
- A minimum of 50% stenosis in culprit artery by visual estimate
- Possibility to perform thrombus aspiration
You may not qualify if:
- Need for emergency coronary artery bypass grafting
- Inability to provide informed consent
- Age below 18 years
- Previous randomization in the TASTE trial
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Region Örebro Countylead
- Uppsala Universitycollaborator
Study Sites (29)
Skejby Hospital, Aarhus University Hospital
Aarhus, Denmark
Landspitali University Hospital
Reykjavik, Iceland
Södra Älvsborgs sjukhus
Borås, Sweden
Mälarsjukhuset
Eskilstuna, Sweden
Falu lasarett
Falun, Sweden
Gävle sjukhus
Gävle, Sweden
Sahlgrenska sjukhuset
Gothenburg, Sweden
Östra sjukhuset
Gothenburg, Sweden
Hallands sjukhus
Halmstad, Sweden
Helsingborgs lasarett
Helsingborg, Sweden
Länssjukhuset Ryhov
Jönköping, Sweden
Länssjukhuset
Kalmar, Sweden
Blekingesjukhuset
Karlskrona, Sweden
Svensk PCI AB, Centralsjukhuset
Karlstad, Sweden
Centralsjukhuset
Kristianstad, Sweden
Universitetssjukhuset
Linköping, Sweden
Sunderby sjukhus
Luleå, Sweden
Lund University Hospital
Lund, Sweden
Skånes universitetssjukhus
Malmo, Sweden
Örebro University Hospital
Örebro, Sweden
Karolinska universitetssjukhuset
Solna, Sweden
Danderyds sjukhus
Stockholm, Sweden
S:t Görans sjukhus
Stockholm, Sweden
Södersjukhuset
Stockholm, Sweden
Länssjukhuset
Sundsvall, Sweden
Norra Älvsborgs länssjukhus
Trollhättan, Sweden
Universitetssjukhuset
Umeå, Sweden
Uppsala University Hospital
Uppsala, Sweden
Centrallasarettet
Västerås, Sweden
Related Publications (6)
Calais F, Lagerqvist B, Leppert J, James SK, Frobert O. Thrombus aspiration in patients with large anterior myocardial infarction: A Thrombus Aspiration in ST-Elevation myocardial infarction in Scandinavia trial substudy. Am Heart J. 2016 Feb;172:129-34. doi: 10.1016/j.ahj.2015.11.012. Epub 2015 Nov 22.
PMID: 26856224DERIVEDFrobert O, Calais F, James SK, Lagerqvist B. ST-elevation myocardial infarction, thrombus aspiration, and different invasive strategies. A TASTE trial substudy. J Am Heart Assoc. 2015 Jun 15;4(6):e001755. doi: 10.1161/JAHA.114.001755.
PMID: 26077585DERIVEDLagerqvist B, Frobert O, Olivecrona GK, Gudnason T, Maeng M, Alstrom P, Andersson J, Calais F, Carlsson J, Collste O, Gotberg M, Hardhammar P, Ioanes D, Kallryd A, Linder R, Lundin A, Odenstedt J, Omerovic E, Puskar V, Todt T, Zelleroth E, Ostlund O, James SK. Outcomes 1 year after thrombus aspiration for myocardial infarction. N Engl J Med. 2014 Sep 18;371(12):1111-20. doi: 10.1056/NEJMoa1405707. Epub 2014 Sep 1.
PMID: 25176395DERIVEDFrobert O, Lagerqvist B, Olivecrona GK, Omerovic E, Gudnason T, Maeng M, Aasa M, Angeras O, Calais F, Danielewicz M, Erlinge D, Hellsten L, Jensen U, Johansson AC, Karegren A, Nilsson J, Robertson L, Sandhall L, Sjogren I, Ostlund O, Harnek J, James SK; TASTE Trial. Thrombus aspiration during ST-segment elevation myocardial infarction. N Engl J Med. 2013 Oct 24;369(17):1587-97. doi: 10.1056/NEJMoa1308789. Epub 2013 Aug 31.
PMID: 23991656DERIVEDFrobert O, Lagerqvist B, Gudnason T, Thuesen L, Svensson R, Olivecrona GK, James SK. Thrombus Aspiration in ST-Elevation myocardial infarction in Scandinavia (TASTE trial). A multicenter, prospective, randomized, controlled clinical registry trial based on the Swedish angiography and angioplasty registry (SCAAR) platform. Study design and rationale. Am Heart J. 2010 Dec;160(6):1042-8. doi: 10.1016/j.ahj.2010.08.040.
PMID: 21146656DERIVEDFrobert O, Lagerqvist B, Kreutzer M, Olivecrona GK, James SK. Thrombus aspiration in ST-elevation myocardial infarction in Sweden: a short report on real world outcome. Int J Cardiol. 2010 Dec 3;145(3):572-3. doi: 10.1016/j.ijcard.2010.05.044. Epub 2010 Jun 13. No abstract available.
PMID: 20550973DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ole Fröbert, MD, PhD
Region Örebro County
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD, PhD
Study Record Dates
First Submitted
March 22, 2010
First Posted
March 25, 2010
Study Start
July 1, 2010
Primary Completion
March 1, 2013
Study Completion
August 1, 2013
Last Updated
July 11, 2016
Record last verified: 2016-07