Long-Term Effectiveness And Safety Of CP-690,550 For The Treatment Of Rheumatoid Arthritis
A Long-term, Open-label Follow-up Study Of Tofacitinib (Cp-690,550) For Treatment Of Rheumatoid Arthritis
2 other identifiers
interventional
4,488
41 countries
458
Brief Summary
The purpose of this study is to determine the long-term effectiveness and safety of CP-690,550 for the treatment of rheumatoid arthritis. Subjects are eligible for this study only after participating in another "qualifying" study of CP-690,550 A sub-study will be conducted within the A3921024 study, this study will evaluate the immune response to pneumococcal and influenza vaccines in patients receiving CP-690,550
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Feb 2007
Longer than P75 for phase_3
458 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 18, 2006
CompletedFirst Posted
Study publicly available on registry
December 20, 2006
CompletedStudy Start
First participant enrolled
February 5, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 30, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
October 26, 2017
CompletedResults Posted
Study results publicly available
March 27, 2018
CompletedOctober 30, 2018
October 1, 2018
9.8 years
December 18, 2006
November 17, 2017
October 1, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (5)
Initial Period: Primary Endpoints Were Standard Laboratory Safety Data (Chemistry, Hematology, Etc.) and Adverse Event (AE) Reports
Treatment-emergent non serious AEs by System Organ Class (SOC) (all causalities) and Laboratory Test Abnormalities (without regard to baseline) The stated number of participants analyzed was the total number of participants in each group (AEs). The actual number of participants analyzed for each laboratory parameter varied, and is provided for each. Abs=absolute; ALT=alanine aminotransferase; AST=aspartate aminotransferase; ESR=erythrocyte sedimentation rate; GGT=gamma glutamyl transferase; hgb=hemoglobin; HDL=high density lipids; LDL=low density lipids; LLN=lower limit of normal; qual=qualitative; Tot=total; ULN=upper limit of normal; WBC=white blood cell
Includes laboratory test abnormality data for all visits and adverse event data up to 999 days after last dose of study drug
Extension Period: Number of Participants With Treatment Emergent Adverse Events (AEs), Serious Adverse Events (SAEs)
An AE was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship. SAE was an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial or prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly. A treatment emergent AE was defined as an event that emerged during the treatment period that was absent before treatment, or worsened during the treatment period relative to the pretreatment state. AEs included both serious and non-serious adverse events.
Baseline (Day 1 at Entry of Extension Period) up to 28 days after last study drug dose in Extension Period (13 Months)
Extension Period: Number of Participants With Laboratory Test Abnormalities
Criteria for laboratory abnormalities: hemoglobin (Hg), hematocrit, red blood cell (RBC), high density lipoprotein (HDL) cholesterol:\<0.8\*lower limit of normal (LLN), platelet\<0.5\*LLN/\>1.75\*upper limit of normal (ULN), white blood cell (WBC)\<0.6\*LLN/\>1.5\*ULN, lymphocyte, neutrophil, protein, albumin \<0.8\*LLN/\>1.2\*ULN, basophil, eosinophil, monocyte, low density lipoprotein (LDL) cholesterol: \>1.2\*ULN; bilirubin\>1.5\*ULN, aspartate amino transferase(AT), alanine AT, gammaglutamyl transferase, alkaline phosphatase:\>3.0\*ULN; blood urea nitrogen, creatinine, cholesterol, triglyceride:\>1.3\*ULN; sodium \<0.95\*LLN/\>1.05\*ULN, potassium, chloride, calcium, bicarbonate: \<0.9\*LLN/\>1.1\*ULN; glucose\<0.6\*LLN/\>1.5\*ULN; Urine (specific gravity\<1.003/\>1.030, pH\<4.5/\>8, glucose, ketone, protein, blood/Hg(\>=1; RBC, WBC\>=20; creatinine kinase\>2\*ULN).
Baseline (Day 1 at Entry of Extension Period) up to 28 days after last study drug dose in Extension Period (13 Months)
Initial Period: The Long Term Safety and Tolerability of CP-690,550 5 Milligrams (mg) Twice Daily (BID) and 10 mg BID for the Treatment of Rheumatoid Arthritis
Treatment-emergent AEs by SOC (all causalities) - all participants, by time. Data presented for Post Month 96 includes data up to and including Month 114.
Includes AEs for every visit and up to 999 days after last dose of study drug
Extension Period: Percentage of Participants With Adverse Events and Who Discontinued Treatment Due to Adverse Events to Assess Long-term Safety and Tolerability of Tofacitinib
Long term safety and tolerability of Tofacitinib was measured as following: percentage (%) of participants with AEs, percentage of participants who discontinued due to AEs. An AE is any untoward medical occurrence in participant who received study drug without regard to possibility of causal relationship.
Baseline (Day 1 at Entry of Extension Period) up to Month 6 of Extension Period; Month 6 of Extension Period to Month 12 of Extension Period
Secondary Outcomes (21)
Initial Period: Percentage of Patients With American College of Rheumatology (ACR) 20, 50, and 70 Responses
Every visit until study completion
Extension Period: Percentage of Participants With American College of Rheumatology (ACR) 20, 50, and 70 Responses
Month 3, 6, 9 and 12 of Extension Period
Initial Period: Area Under American College of Rheumatology (ACR) n Curve
Not applicable as no data were collected for this endpoint.
Initial Period: Disease Activity Score (DAS)28 (C-reactive Protein [CRP]) and DAS28 (Erythrocyte Sedimentation Rate [ESR])
Every visit until study completion
Extension Period: Change From Baseline in Disease Activity Score (DAS) 28-3 C-Reactive Protein (CRP)(DAS28-3 CRP) and DAS28-4 Erythrocyte Sedimentation Rate (ESR)(DAS28-4 ESR) at Month 3, 6, 9 and 12
Baseline (Month 0 at the entry of Initial period); Month 3, 6, 9 and 12 of Extension Period
- +16 more secondary outcomes
Study Arms (2)
Open-Label Active Treatment Enrolled from Phase 2
EXPERIMENTALPatients enrolling from Phase 2 studies
Open-Label Active Treatment Enrolled from Phase 3
EXPERIMENTALPatients enrolling from Phase 3 studies
Interventions
5 mg PO BID open label; may increase to 10 mg PO BID to provide greater control of RA if no related AEs are present. May be off study drug temporarily for up to 28 days for mild to moderate AEs.
Eligibility Criteria
You may qualify if:
- Subjects who have participated in a randomized "qualifying" study of CP-690,550 for the treatment of rheumatoid arthritis
- Vaccine sub-study visit
- Subjects actively participating in Study A3921024 must have completed at least 3 months of continuous 10 mg BID CP-690,550 treatment in A3921024 as defined by \>80% compliance with prescribed dose consumption of CP-690,550 over the previous 3 months.
You may not qualify if:
- Serious medical conditions that would make treatment with CP-690,550 potentially unsafe
- Vaccine sub-study visit
- Any documented influenza or pneumococcal infection within the last 3 months prior to randomization in this study
- Received any vaccine within 1 month prior to randomization in this study
- Received an influenza vaccine within 6 months or a pneumococcal vaccine within 5 years of randomization in this study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Pfizerlead
Study Sites (469)
University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
Rheumatology Associates of North Alabama, PC
Huntsville, Alabama, 35801, United States
Arthrocare, Arthritis Care & Research, PC
Gilbert, Arizona, 85234, United States
Arizona Arthritis & Rheumatology Associates, P.C.
Phoenix, Arizona, 85032, United States
Radiant Research, Inc.
Scottsdale, Arizona, 85251, United States
Catalina Pointe Clinical Research
Tucson, Arizona, 85704, United States
CHI St. Vincent Medical Group Hot Springs
Hot Springs, Arkansas, 71913, United States
NEA Baptist Clinic
Jonesboro, Arkansas, 72401, United States
Osborne Research Center, LLC
Little Rock, Arkansas, 72201, United States
Little Rock Diagnostic Clinic, PA
Little Rock, Arkansas, 72205, United States
Med Investigations, Inc.
Fair Oaks, California, 95628, United States
Talbert Medical Group
Huntington Beach, California, 92646, United States
University of California San Diego Center for Innovative Therapy
La Jolla, California, 92093, United States
Keck Medicine of USC
Los Angeles, California, 90033, United States
University of Southern California (USC) Norris Comprehensive Cancer Center-
Los Angeles, California, 90033, United States
University of Southern California (USC) Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
Ronald Reagan UCLA Medical Center, Drug Information Center
Los Angeles, California, 90095-6984, United States
University of California Los Angeles
Los Angeles, California, 90095, United States
Stanford University School of Medicine
Palo Alto, California, 94304, United States
Office of Anupama Bhat, MD
Roseville, California, 95661, United States
San Diego Arthritis Medical Clinic
San Diego, California, 92108, United States
Pacific Arthritis Center Medical Group
Santa Maria, California, 93454, United States
Stanford Health Services - Medical Specialty Clinics
Stanford, California, 94305, United States
Inland Rheumatology Clinical Trials, Inc.
Upland, California, 91786, United States
Boulder Medical Center, PC
Boulder, Colorado, 80304, United States
Arthritis Associates and Osteoporosis Center of Colorado Springs
Colorado Springs, Colorado, 80910, United States
University of Connecticut Health Center
Farmington, Connecticut, 06030-5353, United States
Arthritis & Osteoporosis Center, PC
Hamden, Connecticut, 06518, United States
New England Research Associates, LLC
Trumbull, Connecticut, 06611, United States
Delaware Arthritis and Osteoporosis Center
Newark, Delaware, 19713, United States
Arthritis and Rheumatic Disease Specialties
Aventura, Florida, 33180, United States
Allergy, Asthma, Arthritis, & Lung
Daytona Beach, Florida, 32114, United States
Physicians Research Alliance LLC
DeBary, Florida, 32713, United States
Southeastern Arthritis Center
Gainesville, Florida, 32607, United States
Southeastern Imaging and Diagnostics
Gainesville, Florida, 32607, United States
Southeastern Integrated Medical PL d/b/a Florida Medical Research Institute
Gainesville, Florida, 32607, United States
Southeastern Integrated Medical, PL, d/b/a Florida Medical Research Institute
Gainesville, Florida, 32607, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
Florida Arthritis Center, P.L.
Lake Mary, Florida, 32746, United States
BayCare Outpatient Imaging at Bardmoor
Largo, Florida, 33777, United States
Center for Arthritis and Rheumatic Diseases
Miami, Florida, 33173, United States
Jeffrey Alper MD Research
Naples, Florida, 34102, United States
Suncoast Clinical Research, Inc.
New Port Richey, Florida, 34652, United States
Ocala Rheumatology Research Center
Ocala, Florida, 34474, United States
Dr. Jeffrey E. Poiley, MD , Office of
Orlando, Florida, 32804, United States
Millennium Research
Ormond Beach, Florida, 32174, United States
DMI Research, Inc.
Pinellas Park, Florida, 33782, United States
Florida Arthritis & Osteoporosis Center
Port Richey, Florida, 34668, United States
Gulf Coast Medical Center
Port Richey, Florida, 34668, United States
Arthritis & Rheumatic Care Center
South Miami, Florida, 33143, United States
Miami Research Associates
South Miami, Florida, 33143, United States
Suncoast Medical Clinic
St. Petersburg, Florida, 33782, United States
West Broward Rheumatology Associates, Inc.
Tamarac, Florida, 33321, United States
BayCare Medical Group, Inc
Tampa, Florida, 33614, United States
Lovelace Scientific Resources
Venice, Florida, 34292, United States
Venice Arthritis Center
Venice, Florida, 34292, United States
Florida Medical Clinic, P.A.
Zephyrhills, Florida, 33542, United States
Arthritis and Rheumatology of Georgia P.C.
Atlanta, Georgia, 30342, United States
Jeffrey D. Lieberman, MD, PC
Decatur, Georgia, 30333, United States
Marietta Rheumatology Associates
Marietta, Georgia, 30060, United States
St. Luke's Clinic - Rheumatology
Boise, Idaho, 83702, United States
St. Luke's Clinic
Boise, Idaho, 83702, United States
St. Luke's Intermountain Research Center
Boise, Idaho, 83702, United States
Institute of Arthritis Research
Idaho Falls, Idaho, 83404, United States
St. Luke's Clinic - Rhematology
Meridian, Idaho, 83642, United States
Loyola University Medical Center
Maywood, Illinois, 60153, United States
Illinois Bone and Joint Institute, LLC
Morton Grove, Illinois, 60053, United States
Rockford Health Physicians
Rockford, Illinois, 61103-3692, United States
Rockford Orthopedic Associates
Rockford, Illinois, 61114, United States
Springfield Clinic
Springfield, Illinois, 62702, United States
Springfield Clinic - Clinical Research
Springfield, Illinois, 62703, United States
Deerbrook Medical Associates
Vernon Hills, Illinois, 60061, United States
Diagnostic Rheumatology And Research PC
Indianapolis, Indiana, 46227, United States
Physician's Clinic of Iowa, P.C.
Cedar Rapids, Iowa, 52403, United States
Medical Associates Clinic, PC
Dubuque, Iowa, 52002, United States
Kansas City Internal Medicine
Overland Park, Kansas, 66209, United States
Professional Research Network of Kansas, LLC
Wichita, Kansas, 67203, United States
Via Christi Clinic, P.A.
Wichita, Kansas, 67208, United States
Bluegrass Community Research, Inc.
Lexington, Kentucky, 40504, United States
Ochsner Clinic Foundation - Baton Rouge
Baton Rouge, Louisiana, 70809, United States
Louisiana State University Health Sciences Center
New Orleans, Louisiana, 70115, United States
Rheumatology Associates
Portland, Maine, 04102, United States
Klein and Associates, MD, PA
Cumberland, Maryland, 21502, United States
The Arthritis Treatment Center
Frederick, Maryland, 21702, United States
The Center for Rheumatology and Bone Research
Wheaton, Maryland, 20902, United States
Clinical Research Center of Cape Cod, Inc.
Hyannis, Massachusetts, 02601, United States
Reliant Medical Group, Inc.
Worcester, Massachusetts, 01605, United States
Reliant Medical Group, Inc. at Worcester Medical Center
Worcester, Massachusetts, 01608, United States
Bronson Internal Medicine and Rheumatology
Battle Creek, Michigan, 49015, United States
QUEST Research Institiute
Bingham Farms, Michigan, 48025, United States
Borgess Research Institute
Kalamazoo, Michigan, 49048, United States
Farmbrook Radiology Associates
Southfield, Michigan, 48034, United States
Arthritis and Rheumatology Consultants, P.A.
Edina, Minnesota, 55435, United States
North Mississippi Medical Clinics, Inc.
Tupelo, Mississippi, 38801, United States
University Physicians - Woodrail Clinic
Columbia, Missouri, 65203, United States
University Of Missouri-Columbia
Columbia, Missouri, 65212, United States
Physician Research Collaboration, LLC
Lincoln, Nebraska, 68516, United States
Clinical Pharmacology Study Group
Massachusetts, Nebraska, 01605, United States
Westroads Clinical Research, Inc.
Omaha, Nebraska, 68114, United States
Heartland Clinic Research, Inc.
Omaha, Nebraska, 68134, United States
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03756, United States
Rheumatology Associates of North Jersey
Teaneck, New Jersey, 07666, United States
Arthritis, Rheumatic & Back Disease Associates
Voorhees Township, New Jersey, 08043, United States
The Center for Rheumatology, LLP
Albany, New York, 12203, United States
Regional Rheumatology Associates
Binghamton, New York, 13905, United States
Southern Tier Arthritis and Rheumatism
Olean, New York, 14760, United States
Buffalo Rheumatology and Medicine, PLLC
Orchard Park, New York, 14127, United States
AAIR Research Center
Rochester, New York, 14618, United States
Asheville Rheumatology & Osteoporosis Research Associates, P.A.
Asheville, North Carolina, 28801, United States
Asheville Rheumatology & Osteoporosis Research Associates, PA
Asheville, North Carolina, 28803, United States
DJL Clinical Research, PLLC
Charlotte, North Carolina, 28210, United States
PMG Research Hickory, LLC
Hickory, North Carolina, 28602, United States
PMG Research of Hickory
Hickory, North Carolina, USA 28602, United States
Boice-Willis Clinic
Rocky Mount, North Carolina, 27804, United States
Trinity Health Center - Medical Arts
Minot, North Dakota, 58701, United States
Cincinnati Rheumatic Disease Study Group, Inc.
Cincinnati, Ohio, 45219, United States
STAT Research, Inc.
Dayton, Ohio, 45417, United States
Office of David R. Mandel, MD, Inc.
Mayfield, Ohio, 44143, United States
Oklahoma Medical Research Foundation (OMRF)
Oklahoma City, Oklahoma, 73104, United States
Lynn Health Science Institute
Oklahoma City, Oklahoma, 73112, United States
East Penn Rheumatology Associates, PC
Bethlehem, Pennsylvania, 18015, United States
Altoona Center for Clinical Research
Duncansville, Pennsylvania, 16635, United States
Rheumatic Disease Associates, Ltd.
Willow Grove, Pennsylvania, 19090, United States
Clinical Research Center of Reading LLP
Wyomissing, Pennsylvania, 19610, United States
Piedmont Arthritis Clinic, PA
Greenville, South Carolina, 29601, United States
Arthritis Associates, PLLC
Hixson, Tennessee, 37343, United States
Arthritis Clinic
Jackson, Tennessee, 38305, United States
West Tennessee Research Institute
Jackson, Tennessee, 38305, United States
Rheumatology Consultants, PLLC
Knoxville, Tennessee, 37909-1907, United States
Vanderbilt University Medical Center
Nashville, Tennessee, 37203, United States
Office of John P. Lavery, MD, PA
Allen, Texas, 75013, United States
Austin Rheumatology Research, PA
Austin, Texas, 78705, United States
Arthritis Care and Diagnostic Center, P.A.
Dallas, Texas, 75231, United States
Baylor Research Institute
Dallas, Texas, 75231, United States
Metroplex Clinical Research Center
Dallas, Texas, 75231, United States
University of North Texas Health Science Center at Fort Worth
Fort Worth, Texas, 76107, United States
Accurate Clinical Research, Inc.
Houston, Texas, 77034, United States
Houston Institute for Clinical Research
Houston, Texas, 77074, United States
Arthritis and Osteoporosis Associates, LLP
Lubbock, Texas, 79424, United States
Southwest Rheumatology Research, LLC
Mesquite, Texas, 75150, United States
Virginia Mason Medical Center
Seattle, Washington, 98101, United States
Seattle Rheumatology Associates
Seattle, Washington, 98122, United States
The Seattle Arthritis Clinic
Seattle, Washington, 98133, United States
Tacoma Center of Arthritis Research, PS
Tacoma, Washington, 98405, United States
The Vancouver Clinic, Inc. PS
Vancouver, Washington, 98664, United States
Mountain State Clinical Research
Clarksburg, West Virginia, 26301, United States
Gundersen Clinic, Ltd
Onalaska, Wisconsin, 54650, United States
OMI- Organizacion Medica de Investigacion
Buenos Aires, Buenos Aires F.D., C1015ABO, Argentina
Centro de Investigaciones Reumatologicas y Osteologicas -CIRO
Buenos Aires, Buenos Aires F.D., C1114AAH, Argentina
Hospital Sirio Libanes
Buenos Aires, 1419AHN, Argentina
OMI - Organización Médica de Investigación
Buenos Aires, C1015ABO, Argentina
Saint Dennis Medical Group S.A.
Buenos Aires, C1034ACO, Argentina
Hospital Sirio Libanes
Buenos Aires, C1419AHN, Argentina
Consultorios Reumatologicos Pampa
Buenos Aires, C1428DZF, Argentina
Optimus Clinical Research Pty. Ltd.
Kogarah, New South Wales, 2217, Australia
Rheumatology Research
Cairns, Queensland, 4870, Australia
Rheumatology Research Unit Sunshine Coast
Maroochydore, Queensland, 4558, Australia
Queen Elizabeth Hospital, Department of Rheumatology
Woodville, South Australia, 5011, Australia
Emeritus Research
Malvern East, Victoria, 3145, Australia
Goatcher Clinical Research Unit
Perth, Western Australia, WA 6000, Australia
Royal North Shore Hospital
St Leonards, NSW2065, Australia
Medizinische Universitaet Wien / AKH
Vienna, A-1090, Austria
Rheuma-Ordination Favoriten
Vienna, A-1100, Austria
Sozialmedizinisches Zentrum Sued - Kaiser Franz Josef Spital
Vienna, A-1100, Austria
Universitair Ziekenhuis Gent - Reumatologie
Ghent, Oost-vlaanderen, 9000, Belgium
AZ Groeninge
Kortrijk, 8500, Belgium
Centre Hospitalier Universitaire de Liège
Liège, 4020, Belgium
University Clinical Center Sarajevo
Sarajevo, 71000, Bosnia and Herzegovina
CIP - Centro Internacional de Pesquisa
Goiânia, Goiás, 74110-120, Brazil
Centro de Estudos em Terapias Inovadoras
Curitiba, Paraná, 80030-110, Brazil
Centro de Estudos em Terapias Inovadoras
Curitiba, Paraná, 80060-240, Brazil
CCBR Brasil Centro de Pesquisas e Analises Clinicas Ltda
Rio de Janeiro, Rio de Janeiro, 22271-100, Brazil
Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Hospital Sao Lucas da PUCRS
Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Hospital Alemao Oswaldo Cruz
São Paulo, São Paulo, 01323-903, Brazil
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP)
São Paulo, São Paulo, 05403-010, Brazil
IMA Brasil -Instituto de Pesquisa Clinica e Medicina Avancada
São Paulo, São Paulo, 05437-010, Brazil
CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda
São Paulo, 04266-010, Brazil
Revmatologichen kabinet, DKTs Sveti Pantaleimon OOD
Pleven, 5800, Bulgaria
Revmatologichno Otdelenie, MBAL - Plovdiv
Plovdiv, 4000, Bulgaria
UMBAL Kaspela Plovdiv
Plovdiv, 4002, Bulgaria
MBAL Akta Medika OOD
Sevlievo, 5400, Bulgaria
Clinic of Cardiology and Rheumatology Military Medical Academy
Sofia, 1606, Bulgaria
Clinic of Rheumatology Multiprofile Hospital for Active treatment Sveti Ivan Rilski
Sofia, 1612, Bulgaria
MBAL Sveti Ivan Rilski Sofia
Sofia, 1612, Bulgaria
DKTs "Sveta Anna" Sofia, Konsultativen kabinet po Revmatologia
Sofia, 1709, Bulgaria
DKTs "Sveta Anna", Sofia / Diagnostic Consultative Center "Sveta Anna"
Sofia, 1709, Bulgaria
MOBAL "D-r Stefan Cherkezov" AD,
Veliko Tarnovo, 5000, Bulgaria
Rheumatology Research Associates Ltd.
Edmonton, Alberta, T5M 0H4, Canada
Dr. Alice Klinkhoff, Inc.
Vancouver, British Columbia, V5Z 1L7, Canada
Percuro Clinical Research Limited
Victoria, British Columbia, V8V 3P9, Canada
Manitoba Clinic
Winnipeg, Manitoba, R3A 1M3, Canada
Nexus Clinical Research
St. John's, Newfoundland and Labrador, A1A 5E8, Canada
Dr. William G. Bensen Medicine Professional Corporation
Hamilton, Ontario, L8N 1Y2, Canada
Office of Dr. Fernando Bianchi
Hamilton, Ontario, L8N 1Y2, Canada
Cividino Medicine Professional Corporation
Hamilton, Ontario, L8N 2B6, Canada
KW Musculoskeletal Research Inc.
Kitchener, Ontario, N2M 5N6, Canada
St Joseph's Health Centre
London, Ontario, N6A 4V2, Canada
Credit Valley Rheumatology
Missisauga, Ontario, L5M 2V8, Canada
The Arthritis Program Research Group Inc.
Newmarket, Ontario, L3Y 3R7, Canada
Rheumatology and Osteoporosis Clinic
Oakville, Ontario, L6M 4J2, Canada
Rheumatology Research Associates
Ottawa, Ontario, K1H 1A2, Canada
Niagara Peninsula Arthritis Centre
St. Catharines, Ontario, L2N 7E4, Canada
Clinical Research and Arthritis Centre
Windsor, Ontario, N8X 5A6, Canada
Institut de Rhumatologie de Montreal
Montreal, Quebec, H2L 1S6, Canada
West Island Rheumatology Research Associates
Pointe-Claire, Quebec, H9R 3J1, Canada
Groupe De Recherche En Rhumatologie Et Maladies Osseuses Inc.
Québec, Quebec, G1V 3M7, Canada
Centre de Recherche Saint-Louis
Québec, Quebec, G1W4R4, Canada
Centre de Recherche Musculo-Squelettique
Trois-Rivières, Quebec, G8Z 1Y2, Canada
Arthritis Research Center, Royal University Hospital
Saskatoon, Saskatchewan, S7N 0W8, Canada
Hospital Base Valdivia, Policlinico de Reumatologia
Valdivia, Region XIV, 5090145, Chile
Consulta Privada Dra. Lucia Ponce
Temuco, Región de la Araucanía, 4790928, Chile
Centro de Estudios Reumatologicos
Santiago, RM, 7501126, Chile
Consulta Privada Dra. Marta Aliste
Santiago, RM, 7510186, Chile
Centro de Diagnostico y Tratamiento Hospital San Borja Arriaran
Santiago, Santiago Metropolitan, 8360156, Chile
Clinica Santa Maria, Seccion Reumatologia
Providencia, Santiago, RM, 7530206, Chile
Hospital Regional de Rancagua
Rancagua, 2841959, Chile
Clinica Santa Maria
Santiago, 7530206, Chile
Estudios Clinicos V Region
Vina Del Mar, V Region, 2520997, Chile
Beijing Chaoyang Hospital, Capital University of Medical Science
Beijing, Beijing Municipality, 100020, China
The Second Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, 510260, China
The Third Affiliated Hospital of Sun Yat-Sen University
Guangzhou, Guangdong, 510630, China
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430030, China
Xiangya Hospital of Centre-south University
Changsha, Hunan, 410008, China
Xijing Hospital, The Fourth Military Medical University
Xi'an, Shaan'xi, 710032, China
QiLu Hospital of Shandong University
Jinan, Shandong, 250012, China
Qingdao Municipal Hospital
Qingdao, Shandong, 266011, China
Shanghai Changzheng Hospital
Shanghai, Shanghai Municipality, 200003, China
Peking University People's Hospital/Rheumatology and Immunology Department
Beijing, 100044, China
PLA General Hospital
Beijing, 100853, China
Si Chuan Huaxi Hospital
Chengdu, 610041, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, 310009, China
Anhui Province Hospital
Hefei, 230001, China
An Hui Medical University 1st Hospital
Hefei, 230022, China
Jiangsu Province Hospital
Nanjing, 210029, China
Rheumatology and Immunology Dept., Renji Hospital Shanghai Jiao Tong University School of Medicine
Shanghai, 200001, China
Shanghai Changhai Hospital
Shanghai, 200433, China
The First Affiliated Hospital of Soochow University
Suzhou, 215006, China
"Department of Infectious Diseases & Immunology
Tianjin, 300052, China
Centro de Reumatologia y Ortopedia S.A.S.
Barranquilla, Atlántico, Colombia
Riesgo de Fractura S.A.
Bogota D.C., Cundinamarca, Colombia
Centro de Investigacion en Reumatologia y Especialidades Medicas S.A.S CIREEM S.A.S
Bogota, D.C., Cundinamarca, Colombia
Servimed S.A.S.
Bucaramanga, Santander Department, 680003, Colombia
Centro de Reumatologia y Osteoporosis, Cartago
Cartago, Costa Rica
Hospital Cima San Jose
San José, 00000, Costa Rica
Hospital Cima San Jose
San José, Costa Rica
Oficina Privada Del Colegio deMedicos
San José, Costa Rica
University Hospital Center Osijek
Osijek, 31000, Croatia
University Hospital Split, Department for Internal Medicine, Division of Clinical Rheumatology
Split, 21000, Croatia
Clinical Hospital "Sveti Duh"
Zagreb, 10 000, Croatia
University Hospital Center "Zagreb"
Zagreb, 10000, Croatia
University Hospital Center Zagreb
Zagreb, 10000, Croatia
X-MEDICA s.r.o.
Brno, 61300, Czechia
Revmacentrum MUDr. Mostera, s.r.o.
Brno, 615 00, Czechia
Fakultni Nemocnice Brno, Interni hematoonkologicka klinika
Brno, 625 00, Czechia
Fakultni nemocnice u sv. Anny v Brne
Brno, 656 91, Czechia
HESTE s.r.o. Revmatologie
Česká Lípa, 470 01, Czechia
MEDIPONT Plus sro
České Budějovice, 370 01, Czechia
L.K.N. Arthrocentrum, s.r.o.
Hlučín, 748 01, Czechia
ARTMEDI UPD s r.o
Hostivice, 253 01, Czechia
Fakultni nemocnice Hradec Kralove
Hradec Králové, 50005, Czechia
Revmatologicka ambulance
Ostrava, 70800, Czechia
ARTHROMED, s. r. o. Revmatologicka ambulance
Pardubice, 530 02, Czechia
Revmatologicky ustav
Prague, 12850, Czechia
Revmatologicka ambulance
Prague, 140 00, Czechia
Fakultni Thomayerova nemocnice s poliklinikou
Prague, 140 59, Czechia
Nuselska poliklinika RTG
Prague, 14000, Czechia
Revmatologicka ambulance
Prague, 14000, Czechia
Affidea Praha, s.r.o.
Praha 11 - Chodov, 148 00, Czechia
Nemocnice Atlas, a.s.
Zlín, 760 01, Czechia
PV-Medical s.r.o.
Zlín, 760 01, Czechia
Frederiksberg Hospital
Frederiksberg, 2000, Denmark
Hospital Central de las Fuerzas Armadas
Santo Domingo, 10119, Dominican Republic
Helsingin Reumakeskus Oy
Helsinki, 00120, Finland
Kiljavan Laaketutkimus Oy
Hyvinkää, 05800, Finland
TAYS/Reumakeskus/Finn-Medi 1
Tampere, 33520, Finland
Hopital Nord
Amiens, 80000, France
Hôpital Nord
Amiens, 80000, France
*CHR Hopital Porte Madeleine IPROS
Orléans, 45000, France
CHR ORLEANS - Service IPROS
Orléans, 45032, France
Hôpital Saint-Antoine
Paris, 75012, France
Hopital Cochin
Paris, 75014, France
Privat-Praxis
Aachen, 52064, Germany
Charite Campus Mitte, Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie
Berlin, 10117, Germany
Schlosspark-Klinik Innere Medizin II, Rheumatologie
Berlin, 14059, Germany
Ambulantes Rheumazentrum Dr Soerensen
Berlin, 14163, Germany
Universitaetsklinikum Koeln Klinik I fuer Innere Medizin, Haus 16, 1. OG, Raum 1.008
Cologne, 50937, Germany
Krankenhaus Friedrichstadt, I. Medizinische Klinik
Dresden, 01067, Germany
Studienambulanz Universitaetsklinikum Erlangen Medizinische Klinik 3
Erlangen, 91054, Germany
J.W.-Goethe-Universitaetsklinik, Medizinische Klinik II, Abteilung fuer Rheumatologie
Frankfurt am Main, 60590, Germany
Schwerpunktpraxis Rheumatologie
Halle, 06108, Germany
Schoen Klinik Hamburg-Eilbek
Hamburg, 22081, Germany
Rheumazentrum Ruhrgebiet
Herne, 44649, Germany
Universitaetsklinik Leipzig, Klinik fur Gastroenterologie und Rheumatologie, Sektion Rheumatologie
Leipzig, 04103, Germany
Universitaetsklinikum Leipzig
Leipzig, 04103, Germany
Klinikum der Universitaet Muenchen, Campus Innenstadt, Rheuma-Einheit
München, 80336, Germany
Arztpraxis, Internist - Rheumatologie
Nuremberg, 90429, Germany
Rheumaforschung- Studienambulanz
Ratingen, 40882, Germany
Schwerpunktpraxis fuer Rheumatologie
Rheine, 48431, Germany
Universitaetsklinikum Wuerzburg
Würzburg, 97080, Germany
General Hospital Euromedica "KYANOUS STAVROS"
Thessaloniki, 54636, Greece
424 General Army Hospital
Thessaloniki, 56429, Greece
Drug Research Center Kft
Balatonfüred, 8230, Hungary
Orszagos Reumatologiai Es Fizioterapias Intezet
Budapest, 1023, Hungary
Revita Reumatologiai Rendelo
Budapest, 1027, Hungary
Synexus Magyarorszag Kft.
Budapest, H-1036, Hungary
MAV Korhaz es Rendelointezet, Reumatologiai szakrendeles
Szolnok, 5000, Hungary
Mahavir Hospital & Research Center
Hyderabad, Andhra Pradesh, 500 004, India
Rheumatic Diseases Clinic
Ahmedabad, Gujarat, 380009, India
Shalby Hospitals
Ahmedabad, Gujarat, 380015, India
Chanre Rheumatology and Immunology Center and Research
Bangalore, Karnataka, 560 003, India
St. John's Medical College and Hospital.
Bangalore, Karnataka, 560 034, India
Shirdi Sai Hospital
Bangalore, Karnataka, 560 054, India
Chanre Rheumatology & Immunology Center & Research
Bangalore, Karnataka, 560 079, India
Arthritis Research and Care Foundation Centre for Rheumatic Diseases
Pune, Maharashtra, 411 001, India
Jehangir Clinical Development Centre Pvt. Ltd.
Pune, Maharashtra, 411001, India
Krishna Institute of Medical Sciences Ltd
Secunderabad, Telangana, 500 003, India
St. Vincent's University Hospital
Elm Park, Dublin, Ireland
A.O.U. Careggi - SOD Medicina Interna 1 e Reumatologia
Florence, FI, 50139, Italy
U.O. Clinica Reumatologica
Genova, 16132, Italy
Hospital Putrajaya, Dept. of Medicine
Putrajaya, Kuala Lumpur, 62250, Malaysia
Hospital Tuanku Ja'afar
Seremban, Negeri Sembilan, 70300, Malaysia
Queen Elizabeth Hospital
Kota Kinabalu, Sabah, 88586, Malaysia
Sarawak General Hospital
Kuching, Sarawak, 93586, Malaysia
Hospital Selayang
Batu Caves, Selangor, 68100, Malaysia
Sunway Medical Centre
Petaling Jaya, Selangor, 46150, Malaysia
Subang Jaya Medical Centre
Subang Jaya, Selangor, 47500, Malaysia
Centro de Investigacion del Noroeste
Tijuana, BAJA California Norte, 22010, Mexico
Unidad de Enfermedades Reumaticas y Cronico Degenerativas SC
Torreón, Coahuila, 27000, Mexico
Centro Integral en Reumatologia, SA de CV
Guadalajara, Jalisco, 44160, Mexico
Unidad de Investigacion en Enfermedades Cronico Degenerativas
Guadalajara, Jalisco, 44620, Mexico
Centro de Investigacion Clinica Especializada, SC
Coyoacán, Mexico City, 04030, Mexico
Hospital Angeles del Pedregal
Mexico City, Mexico City, 10700, Mexico
Centro de Investigacion Clinica de Morelia
Morelia, Michoacán, 58070, Mexico
Clinica de Enfermedades Cronicas y Procedimientos Especiales SC
Morelia, Michoacán, 58249, Mexico
Fundacion El Hospitalito
Cuernavaca, Morelos, 62170, Mexico
Hospital Universitario Doctor Jose Eleuterio Gonzalez
Monterrey, Nuevo León, 64020, Mexico
Centro Medico Toluca
Metepec, State of Mexico, 52140, Mexico
Unidad Reumatologica Las Americas SCP
Mérida, Yucatán, 97000, Mexico
Investigacion y Biomedica de Chihuahua, SC
Chihuahua City, 31000, Mexico
Hospital Angeles Mocel
Mexico City, 11850, Mexico
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mexico City, 14080, Mexico
Centro Reumatologico Queretaro
Querétaro, 76178, Mexico
Centro de Alta Especialidad en Reumatologia e Investigacion del Potosi, S.C.
San Luis Potosí City, 78213, Mexico
Hospital Central Dr Ignacio Morones Prieto Unidad Regional de Reumatologia y Osteoporosis
San Luis Potosí City, 78240, Mexico
The Canterbury Geriatric Medical Research Trust, c/- The Princess Margaret Hospital
Christchurch, 8022, New Zealand
Waikato Hospital, Rheumatology
Hamilton, 3240, New Zealand
Clinical Trials Unit, Timaru Hospital
Timaru, 7910, New Zealand
Hospital Nacional IV Alberto Sabogal Sologuren
Callao, C-02, Peru
Centro Medico Corpac/Investigaciones en Reumatologia
Lima, L-27, Peru
Instituto Peruano del Hueso y la Articulacion SAC-Privado-Lima/Centro de Investigacion IPHAR
Lima, L-27, Peru
Mary Mediatrix Medical Center
Lipa City, Batangas, 4217, Philippines
De La Salle University Health Sciences Campus Clinical Epidemiology Unit
Dasmariñas, Cavite, 4114, Philippines
Angeles University Foundation Medical Center
Angeles City, Pampanga, 2009, Philippines
University of Perpetual Help Rizal Dalta Medical Center
Las Piñas, Philippines, 1742, Philippines
Chong Hua Hospital
Cebu City, 6000, Philippines
Southern Philippine Medical Center
Davao City, 8000, Philippines
University of Santo Tomas Hospital
Manila, 1008, Philippines
"ZDROWIE OSTEO-MEDIC" s.c. Lidia I Artur Racewicz, Agnieszka I Jerzy Supronik
Bialystok, 15-351, Poland
ClinicMed Badurski i wspolnicy Spolka Jawna
Bialystok, 15-879, Poland
NSZOZ Medicus II
Cieszyn, 43400, Poland
Szpital im. Teodora Dunina
Kościan, 64-000, Poland
Krakowskie Centrum Medyczne NZOZ
Krakow, 31-501, Poland
Centrum Badan Klinicznych s.c. Wieslawa Porawska, Lukasz Porawski
Poznan, 60-773, Poland
Wojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-Kosko
Sopot, 81-759, Poland
Nzoz "Nasz Lekarz"
Torun, 87-100, Poland
Synexus Polska Sp. z o.o. Oddzial w Warszawie
Warsaw, 01-192, Poland
Rheuma-Medicus - Specjalistyczne Centrum Reumatologii i Osteoporozy
Warsaw, 02-118, Poland
SYNEXUS Polska Sp. z.o.o.
Wroclaw, 50-088, Poland
Mindful Medical Research
San Juan, PR, 00918, Puerto Rico
Ponce School Of Medicine
Ponce, 00716, Puerto Rico
Edificio Parra
Ponce, 00717-1321, Puerto Rico
Spitalul Clinic "Sf. Maria"
Bucharest, 011172, Romania
Spitalul Clinic De Recuperare
Iași, 700661, Romania
City Clinical Hospital # 1
Novosibirsk, Novosibirsk Oblast, 630047, Russia
"Consultative Diagnostic Rheumatology Center ""Healthy Joints"", LLC"
Novosibirsk, Novosibirsk Oblast, 630091, Russia
State Healthcare Institution City Hospital # 40 of Administrative Health Resort District
Saint Petersburg, Sestroretsk, Russia, 197706, Russia
Smolensk State Medical Academy
Smolensk, Smolensk Oblast, 214019, Russia
State Healthcare Institution Regional Clinical Hospital
Barnaul, 656024, Russia
State Healthcare Institution Regional Clinical Hospital for War Veterans
Kemerovo, 650099, Russia
Russian State Medical University Moscow Faculty City Clinical Hospital #4
Moscow, 115093, Russia
Rheumatology Research Institute of Russian Academy of Medical Sciences
Moscow, 115522, Russia
GUZ Republican Hospital n.a. Baranov
Petrozavodsk, 185019, Russia
Saint-Petersburg State Budgetary Healthcare Institution "Clinical Rheumathology Hospital #25"
Saint Petersburg, 190068, Russia
Clinical Hospital #122 named after L.G. Sokolov of the Federal Medical-Biological Agency
Saint Petersburg, 194291, Russia
Federal North-West Medical Research Centre
Saint Petersburg, 197341, Russia
St. Petersburg State Institution of Healthcare Consultative-diagnostic Center #85
Saint Petersburg, 198260, Russia
Regional State Budget Institution Of Healthcare
Tomsk, 634063, Russia
Regional State Budgetary Healthcare Institution of Tomsk Regional Clinical Hospital
Tomsk, 634063, Russia
State Healthcare Institution
Yekaterinburg, 620102, Russia
State Educational Institution of Higher Professional Education Ural State Medical Academy of Federal
Yekaterinburg, 620149, Russia
State Educational Institution of Higher Professional Education
Yekaterinburg, 620149, Russia
Ltd.Medical Association "Novaya Bolnitsa"
Yekaterinburg, 620219, Russia
Reumatologicka ambulancia, Poliklinika Ruzinov
Bratislava, 82606, Slovakia
NOVAPHARM s.r.o -Zeleznicna NaP, Reumatologicka ambulancia
Bratislava, 832 99, Slovakia
AAGS, s.r.o. , nestatne zdravotnicke zariadenie
Dunajská Streda, 92901, Slovakia
Interna a reumatologicka ambulancia
Košice, 040 01, Slovakia
Ecclesia, s.r.o Reumatologicka ambulancia
Nové Zámky, 94001, Slovakia
Narodny Ustav Reumatickych Chorob
Piešťany, 92112, Slovakia
Reumatologicka ambulancia, MUDr. Zuzana Cizmarikova, s.r.o.
Poprad, 058 01, Slovakia
Reumatologicka ambulancia, REUMEX, s.r.o.
Rimavská Sobota, 979 01, Slovakia
Reumatologicka ambulancia, Nestatne zdravotnicke zariadenie
Senica, 905 01, Slovakia
Nestatna reumatologicka ambulancia, MUDr. Pavol Polak s.r.o.
Žilina, 010 01, Slovakia
Inha University Hospital
Jung-gu, Incheon, 22332, South Korea
Eulji University Hospital
Daejeon, Republic of Korea, 35233, South Korea
Dong-A University Hospital
Busan, 49201, South Korea
Daegu Catholic University Medical Center
Daegu, 42472, South Korea
Chonnam National University Hospital
Gwangju, 61469, South Korea
Seoul National University Hospital
Seoul, 03080, South Korea
Yonsei University Health System
Seoul, 03722, South Korea
Hanyang University Hospital
Seoul, 04763, South Korea
Konkuk University Medical Center
Seoul, 05030, South Korea
Asan Medical Center-University of Ulsan College of Medicine
Seoul, 05505, South Korea
Asan Medical Center
Seoul, 05505, South Korea
Gangnam Severance Hospital-Yonsei University Health System
Seoul, 06273, South Korea
Gangnam Severance Hospital
Seoul, 06273, South Korea
Seoul St. Mary's Hospital-The Catholic University of Korea
Seoul, 06591, South Korea
Hospital Nuestra Senora de la Esperanza
Santiago de Compostela, A Coruna, 15705, Spain
Hospital Clinico Universitario de Santiago
Santiago de Compostela, A Coruna, 15706, Spain
Hospital de Merida
Mérida, Badajoz, 06800, Spain
Hospital Universitario Marques de Valdecilla
Santander, Cantabria, 39008, Spain
Hospital Universitario Cruces
Barakaldo, Vizcaya, 48903, Spain
Hospital de Basurto
Bilbao, Vizcaya, 48013, Spain
Complejo Hospitalario Universitario A Coruna
A Coruña, 15006, Spain
Hospital Del Mar
Barcelona, 08003, Spain
Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
Hospital Universitario De La Paz
Madrid, 28046, Spain
Hospital Civil. Hospital Regional Universitario Carlos Haya
Málaga, 29009, Spain
Hospital Universitario Virgen Macarena
Seville, 41009, Spain
Hospital Nuestra Señora de Valme
Seville, 41014, Spain
Hospital El Tomillar
Seville, 41700, Spain
Hospital Universitari i Politecnic La Fe de Valencia
Valencia, 46026, Spain
Falu lasarett
Falun, 791 82, Sweden
Lanssjukhuset Ryhov
Jönköping, 551 85, Sweden
Skanes Universitetssjukhus i Malmo Reumamottagningen
Malmo, 205 02, Sweden
Sundsvalls Sjukhus
Sundsvall, 851 86, Sweden
Norrlands Universitetssjukhus
Umeå, 901 85, Sweden
Akademiska University Hospital
Uppsala, 75185, Sweden
Chang Gung Medical Foundation-
Niao Sung Hsiang, Kaohsiung County, 833, Taiwan
Chang Gung Medical Foundation-Linkou Branch
Kwei-Shan, Taoyuan County, 333, Taiwan
Changhua Christian Hospital
Changhua, 500, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
Kaohsiung Veterans General Hospital
Kaohsiung City, 813, Taiwan
Taichung Veterans General Hospital
Taichung, 407, Taiwan
National Cheng Kung University Hospital
Tainan, 704, Taiwan
National Taiwan University Hospital
Taipei, 100, Taiwan
Taipei Veterans General Hospital
Taipei, 112, Taiwan
Rheumatology Unit, Department of Internal Medicine, Phramongkutklao Hospital
Rajathevee, Bangkok, 10400, Thailand
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine,
Amphoe Mueang, Chiang Mai, 50200, Thailand
Division of Allergy-Immunology-Rheumatology, Department of Medicine, Faculty of Medicine
Muang District, Khonkaen, 40002, Thailand
Rheumatology Unit, Department of Internal Medicine, Rajavithi Hospital
Bangkok, 10400, Thailand
Siriraj Hospital, Mahidol University
Bangkok, 10700, Thailand
Ege University Medical Faculty
Bornova, İzmir, 35100, Turkey (Türkiye)
Hacettepe University Medical Faculty
Ankara, 06100, Turkey (Türkiye)
Dokuz Eylul Universitesi Arastirma Uygulama Hastanesi
Izmir, 35340, Turkey (Türkiye)
Crimean Republican Institution "Clinical Territorial Medical Association "University Clinic",
Simferopol, Autonomous Republic of Crimea, 95017, Ukraine
CRIMEAN Republican Institution, "Clinical Hospital n.a. M.O. Semashko"
Simferopol Crimea, Ukraine, 95017, Ukraine
Municipal Establishment of Health Care "Kharkiv City Clinical Hospital #8", Dept. of Rheumatology
Kharkiv, 61178, Ukraine
State Institution Republican Clinical Hospital of the Ministry of Health of Ukraine
Kyiv, 04053, Ukraine
State Establishment "Institute of Gerontology of NAMS of Ukraine n.a. D.F. Chebotareva"
Kyiv, 04114, Ukraine
Municipal City Clinical Hospital #4, Policlinic Care
Lviv, 79011, Ukraine
"Multifield Medical Center of Odesa National Medical University ""University Clinic #1"""
Odesa, 65026, Ukraine
Multifield Medical Center of Odesa National Medical University "University Clinic #1"
Odesa, 65026, Ukraine
Vinnitsa Regional Clinical Hospital n.a. Pirogov
Vinnitsa, 21018, Ukraine
Municipal Establishment "City Hospital#7of Zaporizhzhia State Medical University
Zaporizhzhia, 69118, Ukraine
Dudley Group of Hospitals NHS Trust
Dudley, WEST Midlands, DY1 2HQ, United Kingdom
The Royal Wolverhampton NHS Trust
Cannock, WS11 5XY, United Kingdom
Wirral University Teaching Hospital NHS Foundation Trust-Arrowe Park Hospital
Metropolitan Borough of Wirral, CH49 5PE, United Kingdom
Royal Victoria Infirmary
Newcastle upon Tyne, NE1 4LP, United Kingdom
Related Publications (24)
Strand V, Schulze-Koops H, Al-Emadi S, Kinch CD, Gruben D, Germino R, Connell CA, Mysler E. Sex differences in the efficacy, safety and persistence of tofacitinib in patients with rheumatoid arthritis: a post hoc analysis of phase III and long-term extension trials. BMJ Open. 2025 Dec 24;15(12):e082366. doi: 10.1136/bmjopen-2023-082366.
PMID: 41448717DERIVEDPope J, Finckh A, Silva-Fernandez L, Mandl P, Fan H, Rivas JL, Valderrama M, Montoro M. Tofacitinib Monotherapy in Rheumatoid Arthritis: Clinical Trials and Real-World Data Contextualization of Patients, Efficacy, and Treatment Retention. Open Access Rheumatol. 2024 Jun 11;16:115-126. doi: 10.2147/OARRR.S446431. eCollection 2024.
PMID: 38883150DERIVEDCurtis JR, Wollenhaupt J, Tas SW, Chatzidionysiou K, Wang L, Roberts K, Tsekouras V. Determinants of tofacitinib discontinuation in adult patients with rheumatoid arthritis during long-term extension studies up to 9.5 years. Rheumatol Adv Pract. 2024 May 11;8(2):rkae063. doi: 10.1093/rap/rkae063. eCollection 2024.
PMID: 38854417DERIVEDCharles-Schoeman C, Hyde C, Guan S, Parikh N, Wang J, Shahbazian A, Stockert L, Andrews J. Relationship Between Paraoxonase-1 Genotype and Activity, and Major Adverse Cardiovascular Events and Malignancies in Patients With Rheumatoid Arthritis Receiving Tofacitinib. J Rheumatol. 2023 Jul 15:jrheum.2023-0112. doi: 10.3899/jrheum.2023-0112. Online ahead of print.
PMID: 37453736DERIVEDKristensen LE, Danese S, Yndestad A, Wang C, Nagy E, Modesto I, Rivas J, Benda B. Identification of two tofacitinib subpopulations with different relative risk versus TNF inhibitors: an analysis of the open label, randomised controlled study ORAL Surveillance. Ann Rheum Dis. 2023 Jul;82(7):901-910. doi: 10.1136/ard-2022-223715. Epub 2023 Mar 17.
PMID: 36931693DERIVEDHansen KE, Mortezavi M, Nagy E, Wang C, Connell CA, Radi Z, Litman HJ, Adami G, Rossini M. Fracture in clinical studies of tofacitinib in rheumatoid arthritis. Ther Adv Musculoskelet Dis. 2022 Dec 27;14:1759720X221142346. doi: 10.1177/1759720X221142346. eCollection 2022.
PMID: 36601090DERIVEDCurtis JR, Yamaoka K, Chen YH, Bhatt DL, Gunay LM, Sugiyama N, Connell CA, Wang C, Wu J, Menon S, Vranic I, Gomez-Reino JJ. Malignancy risk with tofacitinib versus TNF inhibitors in rheumatoid arthritis: results from the open-label, randomised controlled ORAL Surveillance trial. Ann Rheum Dis. 2023 Mar;82(3):331-343. doi: 10.1136/ard-2022-222543. Epub 2022 Dec 5.
PMID: 36600185DERIVEDWinthrop KL, Yndestad A, Henrohn D, Danese S, Marsal S, Galindo M, Woolcott JC, Jo H, Kwok K, Shapiro AB, Jones TV, Diehl A, Su C, Panes J, Cohen SB. Influenza Adverse Events in Patients with Rheumatoid Arthritis, Ulcerative Colitis, or Psoriatic Arthritis in the Tofacitinib Clinical Development Programs. Rheumatol Ther. 2023 Apr;10(2):357-373. doi: 10.1007/s40744-022-00507-z. Epub 2022 Dec 17.
PMID: 36526796DERIVEDMueller RB, Schulze-Koops H, Furst DE, Cohen SB, Kwok K, Wang L, Killeen T, von Kempis J. Effect of dose adjustments on the efficacy and safety of tofacitinib in patients with rheumatoid arthritis: a post hoc analysis of an open-label, long-term extension study (ORAL Sequel). Clin Rheumatol. 2022 Apr;41(4):1045-1055. doi: 10.1007/s10067-021-05908-z. Epub 2022 Jan 1.
PMID: 34973077DERIVEDWinthrop KL, Curtis JR, Yamaoka K, Lee EB, Hirose T, Rivas JL, Kwok K, Burmester GR. Clinical Management of Herpes Zoster in Patients With Rheumatoid Arthritis or Psoriatic Arthritis Receiving Tofacitinib Treatment. Rheumatol Ther. 2022 Feb;9(1):243-263. doi: 10.1007/s40744-021-00390-0. Epub 2021 Dec 6.
PMID: 34870800DERIVEDCohen SB, Tanaka Y, Mariette X, Curtis JR, Lee EB, Nash P, Winthrop KL, Charles-Schoeman C, Wang L, Chen C, Kwok K, Biswas P, Shapiro A, Madsen A, Wollenhaupt J. Long-term safety of tofacitinib up to 9.5 years: a comprehensive integrated analysis of the rheumatoid arthritis clinical development programme. RMD Open. 2020 Oct;6(3):e001395. doi: 10.1136/rmdopen-2020-001395.
PMID: 33127856DERIVEDvan der Heijde D, Landewe RBM, Wollenhaupt J, Strengholt S, Terry K, Kwok K, Wang L, Cohen S. Assessment of radiographic progression in patients with rheumatoid arthritis treated with tofacitinib in long-term studies. Rheumatology (Oxford). 2021 Apr 6;60(4):1708-1716. doi: 10.1093/rheumatology/keaa476.
PMID: 33057725DERIVEDPanaccione R, Isaacs JD, Chen LA, Wang W, Marren A, Kwok K, Wang L, Chan G, Su C. Characterization of Creatine Kinase Levels in Tofacitinib-Treated Patients with Ulcerative Colitis: Results from Clinical Trials. Dig Dis Sci. 2021 Aug;66(8):2732-2743. doi: 10.1007/s10620-020-06560-4. Epub 2020 Aug 20.
PMID: 32816215DERIVEDKaine J, Tesser J, Takiya L, DeMasi R, Wang L, Snyder M, Soma K, Fan H, Bandi V, Wollenhaupt J. Re-establishment of efficacy of tofacitinib, an oral JAK inhibitor, after temporary discontinuation in patients with rheumatoid arthritis. Clin Rheumatol. 2020 Jul;39(7):2127-2137. doi: 10.1007/s10067-020-04956-1. Epub 2020 Feb 12.
PMID: 32048083DERIVEDWollenhaupt J, Lee EB, Curtis JR, Silverfield J, Terry K, Soma K, Mojcik C, DeMasi R, Strengholt S, Kwok K, Lazariciu I, Wang L, Cohen S. Safety and efficacy of tofacitinib for up to 9.5 years in the treatment of rheumatoid arthritis: final results of a global, open-label, long-term extension study. Arthritis Res Ther. 2019 Apr 5;21(1):89. doi: 10.1186/s13075-019-1866-2.
PMID: 30953540DERIVEDLi ZG, Liu Y, Xu HJ, Chen ZW, Bao CD, Gu JR, Zhao DB, An Y, Hwang LJ, Wang L, Kremer J, Wu QZ. Efficacy and Safety of Tofacitinib in Chinese Patients with Rheumatoid Arthritis. Chin Med J (Engl). 2018 Nov 20;131(22):2683-2692. doi: 10.4103/0366-6999.245157.
PMID: 30425195DERIVEDHall S, Nash P, Rischmueller M, Bossingham D, Bird P, Cook N, Witcombe D, Soma K, Kwok K, Thirunavukkarasu K. Tofacitinib, an Oral Janus Kinase Inhibitor: Pooled Efficacy and Safety Analyses in an Australian Rheumatoid Arthritis Population. Rheumatol Ther. 2018 Dec;5(2):383-401. doi: 10.1007/s40744-018-0118-2. Epub 2018 Jun 11.
PMID: 29949132DERIVEDFleischmann R, Wollenhaupt J, Takiya L, Maniccia A, Kwok K, Wang L, van Vollenhoven RF. Safety and maintenance of response for tofacitinib monotherapy and combination therapy in rheumatoid arthritis: an analysis of pooled data from open-label long-term extension studies. RMD Open. 2017 Dec 18;3(2):e000491. doi: 10.1136/rmdopen-2017-000491. eCollection 2017.
PMID: 29435359DERIVEDFleischmann R, Wollenhaupt J, Cohen S, Wang L, Fan H, Bandi V, Andrews J, Takiya L, Bananis E, Weinblatt ME. Effect of Discontinuation or Initiation of Methotrexate or Glucocorticoids on Tofacitinib Efficacy in Patients with Rheumatoid Arthritis: A Post Hoc Analysis. Rheumatol Ther. 2018 Jun;5(1):203-214. doi: 10.1007/s40744-018-0093-7. Epub 2018 Feb 7.
PMID: 29417430DERIVEDMariette X, Chen C, Biswas P, Kwok K, Boy MG. Lymphoma in the Tofacitinib Rheumatoid Arthritis Clinical Development Program. Arthritis Care Res (Hoboken). 2018 May;70(5):685-694. doi: 10.1002/acr.23421. Epub 2018 Apr 2.
PMID: 28941219DERIVEDCohen SB, Tanaka Y, Mariette X, Curtis JR, Lee EB, Nash P, Winthrop KL, Charles-Schoeman C, Thirunavukkarasu K, DeMasi R, Geier J, Kwok K, Wang L, Riese R, Wollenhaupt J. Long-term safety of tofacitinib for the treatment of rheumatoid arthritis up to 8.5 years: integrated analysis of data from the global clinical trials. Ann Rheum Dis. 2017 Jul;76(7):1253-1262. doi: 10.1136/annrheumdis-2016-210457. Epub 2017 Jan 31.
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Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Limitations and Caveats
1 serious adverse event in the reporting group "Tofacitinib 5 milligram (mg) twice daily (BID)" of Initial Period could not be coded ("septic shock and pneumonia") and has not been included.
Results Point of Contact
- Title
- Pfizer ClinicalTrials.gov Call Center
- Organization
- Pfizer, Inc.
Study Officials
- STUDY DIRECTOR
Pfizer CT.gov Call Center
Pfizer
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 18, 2006
First Posted
December 20, 2006
Study Start
February 5, 2007
Primary Completion
November 30, 2016
Study Completion
October 26, 2017
Last Updated
October 30, 2018
Results First Posted
March 27, 2018
Record last verified: 2018-10