NCT00409422

Brief Summary

To compare anthropometric and metabolic effects of a comprehensive weight management program on obese adolescents and children in comparison to regular clinical weight management visits.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started May 2002

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2002

Completed
4.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2006

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

December 6, 2006

Completed
2 days until next milestone

First Posted

Study publicly available on registry

December 8, 2006

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2007

Completed
Last Updated

June 24, 2008

Status Verified

June 1, 2008

Enrollment Period

4.4 years

First QC Date

December 6, 2006

Last Update Submit

June 20, 2008

Conditions

Keywords

pediatric obesityoverweightinsulin resistancehyperinsulinemiaweight management programfamily-based

Outcome Measures

Primary Outcomes (8)

  • weight

    6 months and 1 year

  • body mass index

    6 months and 1 year

  • % body fat

    6 months and 1 year

  • lipids

    6 months and 1 year

  • blood pressure

    6 months and 1 year

  • glucose

    6 months and 1 year

  • insulin

    6 months and 1 year

  • HOMA index

    6 months and 1 year

Secondary Outcomes (1)

  • planned to compare dieting with non-dieting approach in weight management group

    6 months and 1 year

Interventions

Eligibility Criteria

Age8 Years - 16 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Ages 8-16 years old
  • BMI \>95th percentile for age/gender based on CDC
  • Both primary caregiver/parent and child must agree to participate in the nutrition classes

You may not qualify if:

  • endocrinopathies, including hypothyroidism and diabetes
  • Psychiatric disorders that will interfere with ability to complete follow-up and adherence to protocol
  • Any behavioral or psychosocial issue that will interfere with subject's completion of program, including eating disorder.
  • Any use of medication (steroids, for ex.) that contributes to excess adiposity.
  • Any use of pharmacological intervention for weight management, including prescription medications, over-the-counter medications, or herbal supplements.
  • Any concurrent membership in a weight management program.
  • Inability or unwillingness of parent to accompany the child to nutrition classes.
  • Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Yale University School of Medicine

New Haven, Connecticut, 06520, United States

Location

Related Publications (1)

  • Savoye M, Shaw M, Dziura J, Tamborlane WV, Rose P, Guandalini C, Goldberg-Gell R, Burgert TS, Cali AM, Weiss R, Caprio S. Effects of a weight management program on body composition and metabolic parameters in overweight children: a randomized controlled trial. JAMA. 2007 Jun 27;297(24):2697-704. doi: 10.1001/jama.297.24.2697.

MeSH Terms

Conditions

Pediatric ObesityInsulin ResistanceHyperinsulinismOverweight

Condition Hierarchy (Ancestors)

ObesityOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsGlucose Metabolism DisordersMetabolic Diseases

Study Officials

  • Sonia Caprio, MD

    Yale University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

December 6, 2006

First Posted

December 8, 2006

Study Start

May 1, 2002

Primary Completion

October 1, 2006

Study Completion

February 1, 2007

Last Updated

June 24, 2008

Record last verified: 2008-06

Locations