Chronic and Acute Effects of Smoking on the Left and Right Ventricular Relaxation in Young Healthy Smokers

NCT00395928 | Completed

• 1 other identifier: KB/126/2001
• Study Type: observational
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

Impairment of relaxation, the early phase of ventricular diastole is the first stage of heart diastolic dysfunction. Left ventricular diastolic function can be determined noninvasively by Echo- Doppler - derived mitral valve flow velocities. The addition of pulmonary venous flow pattern enables more accurate assessment of left ventricle diastolic function. The role of the right ventricle in haemodynamic function of the heart is now emphasized. The right ventricle diastolic function can be assess by recording the Doppler tricuspid valve flow pattern. Impaired LV diastolic function usually precedes systolic dysfunction and may cause clinical signs of congestive heart failure. Cigarette smoking is one of the major risk factors for cardiovascular diseases. The aim of the study was to assess left and right ventricular diastolic function in healthy, young and slim smokers before and after smoking one cigarette. Echocardiographic examination: before and after smoking one cigarette Echocardiographic evaluation of mitral valve flow, pulmonary venous flow, tricuspid valve flow and hepatic vein flow to assess diastolic function of ventricles.

Conditions

Cardiovascular Diseases

Keywords

heart; echocardiography; diastolic function; left ventricle; right ventricle; cigarette smoking; Smoking; Heart Ventricles; Diastole; Doppler Echocardiography

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Smokers smoking over 10 cigarettes per day over the last 5 years
• Body mass index \< 25 kg/m2
• Normal blood pressure and normal parameters of echocardiographic examination (wall thickness, left- and right- chamber size, valvular function and left and right ventricular systolic function)
• Normal results of routine physical examination, chest x-ray, standard rest electrocardiogram and routine laboratory tests.

You may not qualify if:

• Body mass index \> 25 kg/m2
• Abnormal blood pressure
• Abnormal parameters of echocardiographic examination (wall thickness, left- and right- chamber size, valvular function and left and right ventricular systolic function)
• Abnormal results of routine physical examination, chest x-ray, standard rest electrocardiogram and routine laboratory tests.

Sponsors & Collaborators

• Medical University of Warsaw: lead

Study Sites (1)

Internal Medicine and Cardiology Dpt,Institute of Dentistry,Warsaw Medical University

Warsaw, Lindleya 4, 02 005, Poland

Location

Related Publications (4)

• Oh JK, Appleton CP, Hatle LK, Nishimura RA, Seward JB, Tajik AJ. The noninvasive assessment of left ventricular diastolic function with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr. 1997 Apr;10(3):246-70. doi: 10.1016/s0894-7317(97)70062-2.

  PMID: 9109691 BACKGROUND

• Klein AL, Tajik AJ. Doppler assessment of pulmonary venous flow in healthy subjects and in patients with heart disease. J Am Soc Echocardiogr. 1991 Jul-Aug;4(4):379-92. doi: 10.1016/s0894-7317(14)80448-3.

  PMID: 1910836 BACKGROUND

• Voutilainen S, Kupari M, Hippelainen M, Karppinen K, Ventila M, Heikkila J. Factors influencing Doppler indexes of left ventricular filling in healthy persons. Am J Cardiol. 1991 Sep 1;68(6):653-9. doi: 10.1016/0002-9149(91)90360-w.

  PMID: 1877483 BACKGROUND

• Alam M, Samad BA, Wardell J, Andersson E, Hoglund C, Nordlander R. Acute effects of smoking on diastolic function in healthy participants: studies by conventional doppler echocardiography and doppler tissue imaging. J Am Soc Echocardiogr. 2002 Oct;15(10 Pt 2):1232-7. doi: 10.1067/mje.2002.124006.

  PMID: 12411910 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Cigarette Smoking; Smoking; Heart Murmurs

Condition Hierarchy (Ancestors)

Tobacco Smoking; Behavior; Tobacco Use; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Danuta Liszewska-Pfejfer, Prof.

  Internal Medicine and Cardiology Dpt, Warsaw Medical University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: November 2, 2006
• First Posted: November 6, 2006
• Study Start: November 1, 2001
• Study Completion: November 1, 2004
• Last Updated: November 6, 2006

Record last verified: 2006-11

Locations

PL (1)