Environmental Exposures, Genetics, and Exhaled Nitric Oxide in Pediatric Asthma
Environmental Exposures, NOS Genes, and Exhaled Nitric Oxide in Pediatric Asthma
3 other identifiers
observational
225
1 country
1
Brief Summary
Asthma is one of the most common childhood diseases. It is chronic and often severely disabling. The amount of nitric oxide that is exhaled while breathing increases with airway inflammation, a symptom of asthma. This study will examine the results from a previous study, the Cincinnati Asthma Prevention (CAP) study, to evaluate the effects of environmental and genetic factors on exhaled nitric oxide (eNO) levels and to determine the relationship between eNO and asthma severity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2006
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2006
CompletedFirst Submitted
Initial submission to the registry
October 31, 2006
CompletedFirst Posted
Study publicly available on registry
November 2, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2008
CompletedAugust 9, 2021
February 1, 2009
1.9 years
October 31, 2006
August 3, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Effects of environmental and genetic factors on exhaled nitric oxide (eNO) levels and the relationship between eNO and asthma severity
Measured through the use of data previously collected in the Cincinnati Asthma Prevention (CAP) study
Eligibility Criteria
Cincinnati area children with asthma
You may qualify if:
- Participated in the Cincinnati Asthma Prevention Study
- Diagnosis of asthma
- Lives with someone that smokes at least 5 cigarettes a day
You may not qualify if:
- No additional neuromuscular or respiratory disorder that may interfere with safe participation in the parent study
- Does not have electricity
- Plans to move within 1 year of entry into the parent study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229-3039, United States
Related Publications (2)
Spanier AJ, Hornung R, Lierl M, Lanphear BP. Environmental exposures and exhaled nitric oxide in children with asthma. J Pediatr. 2006 Aug;149(2):220-6. doi: 10.1016/j.jpeds.2006.04.001.
PMID: 16887438BACKGROUNDWilson SE, Kahn RS, Khoury J, Lanphear BP. Racial differences in exposure to environmental tobacco smoke among children. Environ Health Perspect. 2005 Mar;113(3):362-7. doi: 10.1289/ehp.7379.
PMID: 15743729RESULT
Biospecimen
Blood and urine
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Adam J. Spanier, MD, MPH
Children's Hospital Medical Center, Cincinnati
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 31, 2006
First Posted
November 2, 2006
Study Start
July 1, 2006
Primary Completion
June 1, 2008
Study Completion
June 1, 2008
Last Updated
August 9, 2021
Record last verified: 2009-02