Federal Study of Adherence to Medications in the Elderly (FAME)
1 other identifier
interventional
200
1 country
1
Brief Summary
The purpose of this study is to determine the effect of a comprehensive pharmacy care program on medication adherence and persistence, blood pressure, and LDL cholesterol.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jun 2004
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2004
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2006
CompletedFirst Submitted
Initial submission to the registry
October 26, 2006
CompletedFirst Posted
Study publicly available on registry
October 27, 2006
CompletedOctober 27, 2006
October 1, 2006
October 26, 2006
October 26, 2006
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Change in proportion of pills taken compared to baseline (0-2months) at 8months
Between-group comparison of medication persistence at 14months
Secondary Outcomes (1)
Change in blood pressure and low-density lipoprotein cholesterol at 8months
Interventions
Eligibility Criteria
You may qualify if:
- years or older taking 4 or more chronic medications independently living
You may not qualify if:
- assisted living or nursing home residents presence of any serious medical condition for which 1-year survival was expected to be unlikely
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Walter Reed Army Medical Center
Washington D.C., District of Columbia, 20307, United States
Related Publications (5)
Blackburn DF, Dobson RT, Blackburn JL, Wilson TW. Cardiovascular morbidity associated with nonadherence to statin therapy. Pharmacotherapy. 2005 Aug;25(8):1035-43. doi: 10.1592/phco.2005.25.8.1035.
PMID: 16207093BACKGROUNDAbughosh SM, Kogut SJ, Andrade SE, Larrat P, Gurwitz JH. Persistence with lipid-lowering therapy: influence of the type of lipid-lowering agent and drug benefit plan option in elderly patients. J Manag Care Pharm. 2004 Sep-Oct;10(5):404-11. doi: 10.18553/jmcp.2004.10.5.404.
PMID: 15369423BACKGROUNDJackevicius CA, Mamdani M, Tu JV. Adherence with statin therapy in elderly patients with and without acute coronary syndromes. JAMA. 2002 Jul 24-31;288(4):462-7. doi: 10.1001/jama.288.4.462.
PMID: 12132976BACKGROUNDSokol MC, McGuigan KA, Verbrugge RR, Epstein RS. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care. 2005 Jun;43(6):521-30. doi: 10.1097/01.mlr.0000163641.86870.af.
PMID: 15908846BACKGROUNDLee JK, Grace KA, Taylor AJ. Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: a randomized controlled trial. JAMA. 2006 Dec 6;296(21):2563-71. doi: 10.1001/jama.296.21.joc60162. Epub 2006 Nov 13.
PMID: 17101639DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Allen J Taylor, MD
Walter Reed Army Medical Center
- PRINCIPAL INVESTIGATOR
Jeannie K Lee, Pharm.D
Walter Reed Army Medical Center
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- ECT
- Intervention Model
- PARALLEL
- Sponsor Type
- FED
Study Record Dates
First Submitted
October 26, 2006
First Posted
October 27, 2006
Study Start
June 1, 2004
Study Completion
August 1, 2006
Last Updated
October 27, 2006
Record last verified: 2006-10