NCT00369473

Brief Summary

The purpose of this study is to assess long-term safety of SC AMG 108 in the treatment of RA

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
690

participants targeted

Target at P75+ for phase_2 rheumatoid-arthritis

Timeline
Completed

Started Sep 2006

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 24, 2006

Completed
5 days until next milestone

First Posted

Study publicly available on registry

August 29, 2006

Completed
3 days until next milestone

Study Start

First participant enrolled

September 1, 2006

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2008

Completed
Last Updated

December 13, 2016

Status Verified

December 1, 2016

Enrollment Period

1.8 years

First QC Date

August 24, 2006

Last Update Submit

December 9, 2016

Conditions

Keywords

rheumatoid arthritis

Outcome Measures

Primary Outcomes (1)

  • To assess long-term safety of AMG 108 SC in subjects with RA previously enrolled in study 20050168

    144 Weeks

Secondary Outcomes (1)

  • To determine whether long-term use of AMG 108 improves function in subjects with RA

    144 Weeks

Study Arms (2)

1

EXPERIMENTAL

350

Drug: AMG 108

2

EXPERIMENTAL

350

Drug: AMG 108

Interventions

125 mg via SC (subcutaneous) injection every 4 weeks

1

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Only subjects eligible for and completing 24 weeks of study 20050168 will be permitted to enroll.

You may not qualify if:

  • Subjects not eligible for or not completing 24 weeks of study 20050168 will be excluded.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Links

MeSH Terms

Conditions

Arthritis, Rheumatoid

Interventions

AMG 108

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic DiseasesConnective Tissue DiseasesSkin and Connective Tissue DiseasesAutoimmune DiseasesImmune System Diseases

Study Officials

  • MD

    Amgen

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 24, 2006

First Posted

August 29, 2006

Study Start

September 1, 2006

Primary Completion

June 1, 2008

Study Completion

June 1, 2008

Last Updated

December 13, 2016

Record last verified: 2016-12