NCT00367367

Brief Summary

Studies have shown that endometrial sampling in the month prior to embryo transfer may increase pregnancy rates. We wish to test this hypothesis by performing a hysteroscopy and curettage in the month proceeding embryo transfer during IVF, IVF/ICSI or Frozen/Thawed cycles.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
90

participants targeted

Target at P50-P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2005

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

August 20, 2006

Completed
2 days until next milestone

First Posted

Study publicly available on registry

August 22, 2006

Completed
Last Updated

August 22, 2006

Status Verified

August 1, 2006

First QC Date

August 20, 2006

Last Update Submit

August 20, 2006

Conditions

Infertility

Keywords

embryo transferhysteroscopycurettageiv-vitro fertilizationmolecular markersendometrial receptivityendometrial dating

Outcome Measures

Primary Outcomes (3)

  • Implantation rate

  • Pregnancy rate

  • Endometrial receptivity

Interventions

Hysteroscopy and CurettagePROCEDURE

Eligibility Criteria

Age18 Years - 35 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Informed consent
  • In-vitro fertilization candidate
  • Normal blood coagulation

You may not qualify if:

  • Anemia (hemoglobin under 10 mg/dl)
  • Abnormal maternal karyotype
  • Thrombocytopenia under 140,000
  • Any contraindication to hysteroscopy or in-vitro fertilization

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Obstetrics and gynecology, HaEmek Medical Center

Afula, 18101, Israel

RECRUITING

Related Publications (2)

  • La Sala GB, Montanari R, Dessanti L, Cigarini C, Sartori F. The role of diagnostic hysteroscopy and endometrial biopsy in assisted reproductive technologies. Fertil Steril. 1998 Aug;70(2):378-80. doi: 10.1016/s0015-0282(98)00147-2.

    PMID: 9696242RESULT

  • Barash A, Dekel N, Fieldust S, Segal I, Schechtman E, Granot I. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril. 2003 Jun;79(6):1317-22. doi: 10.1016/s0015-0282(03)00345-5.

    PMID: 12798877RESULT

MeSH Terms

Conditions

Infertility

Interventions

HysteroscopyCurettage

Condition Hierarchy (Ancestors)

Genital DiseasesUrogenital Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Obstetrical and GynecologicalDiagnostic Techniques and ProceduresDiagnosisEndoscopyDiagnostic Techniques, SurgicalMinimally Invasive Surgical ProceduresSurgical Procedures, OperativeObstetric Surgical ProceduresGynecologic Surgical ProceduresUrogenital Surgical Procedures

Study Officials

  • Joel Geslevich, MD

    haemek medical center

    PRINCIPAL INVESTIGATOR

  • Eliezer Shalev

    HaEmek Medicak Center and Technion, Israel Institute of Technology

    STUDY CHAIR

  • Shlomit Goldman

    haemek medical center

    STUDY DIRECTOR

Central Study Contacts

Amir Weiss, MD

CONTACT

972-4-6494031weiss_am@clalit.org.il

Joel Geslevich, MD

CONTACT

972-4-6495488yoel_g@clalit.org.il

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

August 20, 2006

First Posted

August 22, 2006

Study Start

December 1, 2005

Last Updated

August 22, 2006

Record last verified: 2006-08

Locations

IL(1)