NCT00358137

Brief Summary

This study will evaluate the effect of an aerobic training program versus a strength training program on the autonomic nervous system at rest and in response to challenge.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
149

participants targeted

Target at P50-P75 for not_applicable hypertension

Timeline
Completed

Started Jul 1997

Longer than P75 for not_applicable hypertension

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 1997

Completed
5.5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2003

Completed
3.6 years until next milestone

First Submitted

Initial submission to the registry

July 28, 2006

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 31, 2006

Completed
Last Updated

February 18, 2016

Status Verified

December 1, 2007

First QC Date

July 28, 2006

Last Update Submit

February 17, 2016

Conditions

HypertensionCardiovascular Diseases

Keywords

Blood Pressure, High

Outcome Measures

Primary Outcomes (1)

  • RR inverval (RRV) and blood pressure variability at rest and in response to challenge (measured prior to exercise training and again after training and after sedentary deconditioning).

Secondary Outcomes (1)

  • Secondary outcome measures include ambulatory blood pressure.

Interventions

Aerobic Conditioning ProgramBEHAVIORAL
Strength Training ProgramBEHAVIORAL

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Average cardiorespiratory fitness level, as defined by the American Heart Association (VO2 max \[maximum oxygen consumption\] less than 43 ml/kg/min for men and less than 37 ml/kg/min for women)
  • English speaking
  • Ambulatory
  • Sedentary

You may not qualify if:

  • Use of psychotropic medications
  • Past or current psychiatric disorder
  • Heart disease
  • High blood pressure
  • Diabetes mellitus
  • Neurologic disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Alex C, Lindgren M, Shapiro PA, McKinley PS, Brondolo EN, Myers MM, Zhao Y, Sloan RP. Aerobic exercise and strength training effects on cardiovascular sympathetic function in healthy adults: a randomized controlled trial. Psychosom Med. 2013 May;75(4):375-81. doi: 10.1097/PSY.0b013e3182906810. Epub 2013 Apr 29.

    PMID: 23630307DERIVED

MeSH Terms

Conditions

HypertensionCardiovascular Diseases

Condition Hierarchy (Ancestors)

Vascular Diseases

Study Officials

  • Richard P. Sloan, PhD

    Columbia University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
NIH

Study Record Dates

First Submitted

July 28, 2006

First Posted

July 31, 2006

Study Start

July 1, 1997

Study Completion

January 1, 2003

Last Updated

February 18, 2016

Record last verified: 2007-12