NCT00355459

Brief Summary

The purpose of this research project is to determine the effects of oral tetracycline such as Minocycline (Minocin) on tear film composition and tear lipid (meibomian gland secretions) characteristics in patients with chronic Blepharitis and associated dry eyes.

Trial Health

30
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Timeline
Completed

Started Aug 2005

Geographic Reach
1 country

1 active site

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2005

Completed
12 months until next milestone

First Submitted

Initial submission to the registry

July 20, 2006

Completed
4 days until next milestone

First Posted

Study publicly available on registry

July 24, 2006

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2007

Completed
Last Updated

December 13, 2018

Status Verified

December 1, 2018

First QC Date

July 20, 2006

Last Update Submit

December 12, 2018

Conditions

Dry Eye Syndrome

Keywords

Meibomian Gland Dystrophy

Outcome Measures

Primary Outcomes (3)

  • Evaporometry

  • Fluorophotometery

  • Meibomian gland expression and lipid analysis

Secondary Outcomes (4)

  • Schirmers Testing

  • TBUT

  • Bacteriology

  • Transillumination & Meibography

Interventions

Tetracycline: Doxycycline analogDRUG

Eligibility Criteria

Age18 Years - 88 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Texas Southwestern Medical Center at Dallas

Dallas, Texas, 75390-8866, United States

Location

MeSH Terms

Conditions

Dry Eye Syndromes

Condition Hierarchy (Ancestors)

Lacrimal Apparatus DiseasesEye Diseases

Study Officials

  • James P. McCulley, M.D.

    University of Texas, Southwestern Medical Center at Dallas

    PRINCIPAL INVESTIGATOR
0

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

July 20, 2006

First Posted

July 24, 2006

Study Start

August 1, 2005

Study Completion

April 1, 2007

Last Updated

December 13, 2018

Record last verified: 2018-12

Locations

US(1)