NCT00342576|Completed
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Sponsor study identifier
Secondary identifiers
observational
1,500
1 country
1
Study Start
April 23, 1994
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
July 15, 2019
Date type not reportedThis date has not been verified as actual or estimated.
Patients admitted on this protocol will have, or be suspected of having, one of the lymphatic filarial infections affecting humans. After routine clinical evaluation they will be studied in depth immunologically, and their blood cells and/or serum will be collected to provide reagents (eg., specific antibodies, T cell clones, etc.) that will be used in the laboratory to address the broader questions of immunodiagnosis, immunoregulation, immunopathology and immunoprophylaxis. Careful observations of the patients' clinical and immunologic responses to therapy will be made, as well as long-term follow-up of these changes. It is anticipated both that the patients will receive optimal clinical care for their infections and that the specimens collected from them will prove to be valuable reagents for the laboratory studies of the immunologic responses unique to filarial or other helminthic infections.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 15, 2019
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 23, 1994
Date type not reportedThis date has not been verified as actual or estimated.
June 19, 2006
Actual (reported)June 21, 2006
Actual (reported)July 15, 2019
Date type not reportedThis date has not been verified as actual or estimated.
Contact the study team to confirm eligibility.
Tuberculosis Research Centre
Chennai, India
Piessens WF, Partono F, Hoffman SL, Ratiwayanto S, Piessens PW, Palmieri JR, Koiman I, Dennis DT, Carney WP. Antigen-specific suppressor T lymphocytes in human lymphatic filariasis. N Engl J Med. 1982 Jul 15;307(3):144-8. doi: 10.1056/NEJM198207153070302.
Nutman TB, Kumaraswami V, Pao L, Narayanan PR, Ottesen EA. An analysis of in vitro B cell immune responsiveness in human lymphatic filariasis. J Immunol. 1987 Jun 1;138(11):3954-9.
Thomas B Nutman, M.D.
National Institute of Allergy and Infectious Diseases (NIAID)
1,500 participants (actual enrollment reported by the registry).
First Submitted
June 19, 2006
First Posted
June 21, 2006
Study Start
April 23, 1994
Date type not reportedThis date has not been verified as actual or estimated.
Nutman TB, Kumaraswami V, Ottesen EA. Parasite-specific anergy in human filariasis. Insights after analysis of parasite antigen-driven lymphokine production. J Clin Invest. 1987 May;79(5):1516-23. doi: 10.1172/JCI112982.
Study Completion
July 15, 2019
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
July 18, 2019
Record last verified: 2019-07-15
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