A Prospective Cohort Study of Occupational Exposures and Cancer Risk Among Women

NCT00342004 | Completed

• 2 other identifiers: 999998006OH98-C-N006
• Study Type: observational
• Target: 75,366
• Locations: 1 country
• Sites: 1

Brief Summary

A prospective cohort study is proposed to evaluate occupational and environmental risk factors for cancer among women in Shanghai, China. Approximately 75,000 women aged 40-69 who reside in eight geographically defined communities in two urban districts of Shanghai will be recruited via a community-based cancer education program. All eligible subjects will be invited by local health workers from the neighborhood health station to the clinic for an interview and selected anthropometric measurements. The interview will elicit information on demographic background, diet, lifestyle factors, medical history, lifetime occupational history and residential history for the past 20 years. In addition, the women will be asked for information on their husbands' current and usual occupations, and demographic and a few other exposure factors. A spot urine sample and 10 ml of blood will be collected from all cohort members and stored at -70 degrees C for future assays of urine metabolites and DNA and hemoglobin adducts of selected occupational and environmental carcinogens, and polymorphic genes encoding enzymes that are involved in metabolism of relevant carcinogens. Cohort members and their husbands will be followed for cancer outcomes through biennial recontact and linkage with files of the population-based Shanghai Cancer Registry, of the Shanghai Vital Statistics, and of the Shanghai Resident Registry. Medical records and pathology slides will be reviewed for all cancer cases to verify their diagnosis. Post-diagnostic blood samples will be obtained from all cohort members diagnosed with cancer during the follow-up period and stored for future methodologic and etiologic studies. The proposed initial study period is 5 years, with an average follow-up of about 3.5 years. We anticipate, however, that follow-up will continue for 10 years or more.

Conditions

Lung Cancer; Non-Hodgkin Lymphoma; Breast Cancer; Stomach Cancer; Brain Cancer

Keywords

Shanghai; Residential History; Exposure Assessment; Cohort Study; Molecular Epidemiology

Outcome Measures

Primary Outcomes (1)

• All cancer incidence

  Any cancer incidence, selected chronic diseases and all causemortality

  up to 30 years

Secondary Outcomes (1)

• All deaths

  up to 30 years

Study Arms (1)

Healthy Volunteers

Healthy female urban residents in Shanghai between ages of 40-70.

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy female urban residents in Shanghai between ages of 40-70.

You may qualify if:

• Women aged 40-69 who are permanent residents in eight geographically defined communities of urban Shanghai.

Sponsors & Collaborators

• National Cancer Institute (NCI): lead

Study Sites (1)

Shanghai Cancer Institute

Shanghai, China

Location

Related Publications (3)

• Cantor KP, Stewart PA, Brinton LA, Dosemeci M. Occupational exposures and female breast cancer mortality in the United States. J Occup Environ Med. 1995 Mar;37(3):336-48. doi: 10.1097/00043764-199503000-00011.

  PMID: 7796202 BACKGROUND

• Chow WH, Dosemeci M, Zheng W, Vetter R, McLaughlin JK, Gao YT, Blot WJ. Physical activity and occupational risk of colon cancer in Shanghai, China. Int J Epidemiol. 1993 Feb;22(1):23-9. doi: 10.1093/ije/22.1.23.

  PMID: 8449643 BACKGROUND

• Chow WH, Ji BT, Dosemeci M, McLaughlin JK, Gao YT, Fraumeni JF Jr. Biliary tract cancers among textile and other workers in Shanghai, China. Am J Ind Med. 1996 Jul;30(1):36-40. doi: 10.1002/(SICI)1097-0274(199607)30:13.0.CO;2-Q.

  PMID: 8837680 BACKGROUND

MeSH Terms

Conditions

Lung Neoplasms; Lymphoma, Non-Hodgkin; Breast Neoplasms; Stomach Neoplasms; Brain Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Lymphoma; Neoplasms by Histologic Type; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Gastrointestinal Neoplasms; Digestive System Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Stomach Diseases; Central Nervous System Neoplasms; Nervous System Neoplasms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Qing Lan, M.D.

  National Cancer Institute (NCI)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 19, 2006
• First Posted: June 21, 2006
• Study Start: May 1, 1997
• Primary Completion: July 28, 2020
• Study Completion: July 28, 2020
• Last Updated: August 4, 2020

Record last verified: 2020-07

Locations

CN (1)