NCT00339599|Completed
Genetic Predictors of Cardiovascular Disease
Study of Chemokine Markers and Genes as Predictors of Cardiovascular Disease
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Study of Chemokine Markers and Genes as Predictors of Cardiovascular Disease
Sponsor study identifier
Secondary identifiers
observational
2,306
1 country
1
Study Start
September 20, 2005
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
August 3, 2015
Date type not reportedThis date has not been verified as actual or estimated.
This study, conducted in collaboration with the Johns Hopkins University School of Medicine, will explore the genetic influences on susceptibility to atherosclerotic cardiovascular disease (ASCVD). Atherosclerosis is a chronic narrowing of the arteries caused by an incremental buildup of fatty substances on the linings of walls of arteries. This study will examine the role of genes related to the inflammatory process on the incidence of ASCVD and on levels of chemokines (proteins involved in inflammation). DNA samples, chemokines levels and relevant clinical data from patients enrolled in Johns Hopkins's sibling and family heart studies are analyzed for specific gene markers. The studies include: Nurse Model in Black Families at Risk for Heart Disease; Genotypic Determinants of Aspirin Response in High Risk Families; and Coronary Disease Detection by Thallium SPECT and Fast CT. All of the enrolled patients have consented to have their DNA used for testing of genetic factors that may predict cardiovascular disease and do not contain patient identifier information.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 3, 2015
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 20, 2005
Date type not reportedThis date has not been verified as actual or estimated.
June 19, 2006
Actual (reported)June 21, 2006
Actual (reported)August 3, 2015
Date type not reportedThis date has not been verified as actual or estimated.
Contact the study team to confirm eligibility.
National Cancer Institute (NCI), 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med. 1999 Jan 14;340(2):115-26. doi: 10.1056/NEJM199901143400207. No abstract available.
Francis SE, Camp NJ, Dewberry RM, Gunn J, Syrris P, Carter ND, Jeffery S, Kaski JC, Cumberland DC, Duff GW, Crossman DC. Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease. Circulation. 1999 Feb 23;99(7):861-6. doi: 10.1161/01.cir.99.7.861.
Janelle Cortner, Ph.D.
National Cancer Institute (NCI)
2,306 participants (actual enrollment reported by the registry).
First Submitted
June 19, 2006
First Posted
June 21, 2006
Study Start
September 20, 2005
Date type not reportedThis date has not been verified as actual or estimated.
Role of Nitric Oxide in the Impact of Aging on Myocardial Remodeling
Rovin BH, Lu L, Saxena R. A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression. Biochem Biophys Res Commun. 1999 Jun 7;259(2):344-8. doi: 10.1006/bbrc.1999.0796.
Study Completion
August 3, 2015
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
November 8, 2019
Record last verified: 2015-08-03
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Source: ClinicalTrials.gov.
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