Factors Promoting Increased Rate and Success of Pregnancy in the Thalassemia Population in Toronto

NCT00327639 | Unknown

• 1 other identifier: 00000
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Treatment of patients with beta thalassemia in North America has altered dramatically during the past 40 years, with improvements in transfusion therapy and introduction of iron chelation therapy. Thalassemia patients now enjoy an increased life expectancy to the fifth and sixth decades of life, with fertility and childbearing becoming important issues. Data regarding this important topic remain limited, without clear data regarding iron control including serial assessment of hepatic iron concentration, the need for assistance in becoming pregnant, and use of iron chelating agents during pregnancy. As the life expectancy increases and overall health improves in thalassemia, clear data on fertility, pregnancy complications, and the effect of pregnancy on maternal health in thalassemia patients are necessary since these will have a direct impact on patient care, quality of life, and patient expectations.

Conditions

Thalassemia; Fertility; Pregnancy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Thalassemia, thalassemia intermedia or E-thalassemia patients in Toronto
• Subject has attempted conception

You may not qualify if:

• Subject has any other form of blood disease
• Subject has not attempted conception

Sponsors & Collaborators

• University Health Network, Toronto: lead

Study Sites (1)

University Health Network, Toronto General Hospital

Toronto, Ontario, M5G 2C4, Canada

RECRUITING

MeSH Terms

Conditions

Thalassemia

Condition Hierarchy (Ancestors)

Anemia, Hemolytic, Congenital; Anemia, Hemolytic; Anemia; Hematologic Diseases; Hemic and Lymphatic Diseases; Hemoglobinopathies; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Nancy F Olivieri, MD

  University Health Network, Toronto General Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Anthony Apostoli, B.Sc.

CONTACT

416-340-4800; Anthony.Apostoli@uhn.on.ca

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 17, 2006
• First Posted: May 18, 2006
• Study Start: July 1, 2005
• Last Updated: May 18, 2006

Record last verified: 2005-07

Locations

CA (1)