NCT00327431

Brief Summary

Research suggests that blood pressure is influenced by both genetic and environmental factors. The goal of this study is to find genes that play a role in blood pressure and understand how they interact with life events (such as job stress) to influence blood pressure. We hypothesize that the gene for endothelin-1 is associated with increased blood pressure. Further, we predict that this genetic relationship is moderated by psychosocial stress factors, specifically job strain and marital cohesion.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Nov 2006

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 17, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 18, 2006

Completed
6 months until next milestone

Study Start

First participant enrolled

November 1, 2006

Completed
1.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2007

Completed
Last Updated

May 22, 2008

Status Verified

May 1, 2008

First QC Date

May 17, 2006

Last Update Submit

May 21, 2008

Conditions

HypertensionPsychosocial Factors

Keywords

HypertensionBlood PressurePsychosocial Factors

Interventions

Cheek swab samples for DNAGENETIC

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Previous participation in a study of psychosocial stressors and blood pressure (Double Exposure Study) and agreement to participate in follow-up studies

You may not qualify if:

  • Withdrawal of consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada

Location

Related Publications (1)

  • Tobe SW, Kiss A, Szalai JP, Perkins N, Tsigoulis M, Baker B. Impact of job and marital strain on ambulatory blood pressure results from the double exposure study. Am J Hypertens. 2005 Aug;18(8):1046-51. doi: 10.1016/j.amjhyper.2005.03.734.

    PMID: 16109318BACKGROUND

MeSH Terms

Conditions

Hypertension

Interventions

DNA

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

Nucleic AcidsNucleic Acids, Nucleotides, and Nucleosides

Study Officials

  • Brian Baker, MB, ChB

    University of Toronto

    STUDY CHAIR

  • Sheldon Tobe, MD

    Sunnybrook Health Sciences Centre

    STUDY CHAIR

Study Design

Study Type
observational
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

May 17, 2006

First Posted

May 18, 2006

Study Start

November 1, 2006

Study Completion

December 1, 2007

Last Updated

May 22, 2008

Record last verified: 2008-05

Locations

CA(1)