NCT00549991

Brief Summary

High blood pressure is one of the most common health problems in the United States. Genetic variations may cause some people to be more susceptible to developing high blood pressure. This study will identify variations in genes known to play a part in the development of high blood pressure.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
8,687

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2007

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2007

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

October 24, 2007

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 26, 2007

Completed
4.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2012

Completed
Last Updated

September 10, 2025

Status Verified

September 1, 2025

Enrollment Period

4.8 years

First QC Date

October 24, 2007

Last Update Submit

September 4, 2025

Conditions

Hypertension

Keywords

High Blood Pressure

Outcome Measures

Primary Outcomes (1)

  • Genetic variations

    Measured through admixture mapping genetic analysis

Eligibility Criteria

Age21 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Previously collected genetic samples from African American participants in the Family Blood Pressure Program (FBPP) study and from African American, Mexican American, Nigerian, and Jamaican participants enrolled in other clinical studies will be examined.

You may qualify if:

  • Participated in the FBPP study (African American \[800 people with high blood pressure and 800 control group participants\] and Mexican American participants)
  • Participated in the American Family Study (African American participants)
  • Participated in the Phenotyping Study (African American, Nigerian, and Jamaican participants)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Case Western Reserve University

Cleveland, Ohio, 44106, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular Diseases

Study Officials

  • Xiaofeng Zhu, PhD

    Case Western Reserve University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 24, 2007

First Posted

October 26, 2007

Study Start

August 1, 2007

Primary Completion

June 1, 2012

Study Completion

June 1, 2012

Last Updated

September 10, 2025

Record last verified: 2025-09

Locations

US(1)