NCT00324571

Brief Summary

This is a randomized, open-label, parallel-design study to be conducted at 75 centers within the United States. The study will be described to hemodialysis patients. Informed consent will be obtained and the inclusion/exclusion criteria reviewed. Eligible patients will be randomized to receive either Renagel or a calcium-based binder. Starting from the randomization date, mortality data including survival, death date and cause of death (vital status information) and morbidity data including hospitalization date will be recorded for all patients. These data will be collected until the end of the study (December 31, 2004, ± 2 weeks). Patients completing or terminating from the study will return to the phosphate binder prescribed by their usual healthcare provider.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,000

participants targeted

Target at P75+ for phase_4

Timeline
Completed

Started Mar 2001

Longer than P75 for phase_4

Geographic Reach
2 countries

73 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2001

Completed
4.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2006

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

May 9, 2006

Completed
2 days until next milestone

First Posted

Study publicly available on registry

May 11, 2006

Completed
Last Updated

March 18, 2015

Status Verified

March 1, 2015

First QC Date

May 9, 2006

Last Update Submit

March 17, 2015

Conditions

Outcome Measures

Primary Outcomes (2)

  • Efficacy will be evaluated based on a comparison of the association of Renagel use versus calcium-based phosphate binder use on all-cause mortality, cause-specific mortality (cardiovascular, infection, other), and all-cause hospitalization.

  • Safety will be assessed based on an evaluation of related serious adverse events.

Interventions

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • patients must be 18 years of age or older,
  • on dialysis for more than 3 months,
  • require phosphate binder therapy,
  • have Medicare as their primary insurance.

You may not qualify if:

  • dysphagia,
  • swallowing disorders,
  • severe gastrointestinal motility disorders,
  • bowel obstruction.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (73)

Gambro Healthcare-Gadsden

Gadsden, Alabama, United States

Location

nTouch Research

Huntsville, Alabama, United States

Location

Kidney Health Institute, LLC

Tucson, Arizona, United States

Location

Gambro Healthcare

El Cerrito, California, United States

Location

Palomar Medical Group

Escondido, California, United States

Location

Gambro Healthcare-Los Angeles

Los Angeles, California, United States

Location

Balboa Nephrology Medical Group

San Diego, California, United States

Location

Nephrology Educational Services and Research

Tarzana, California, United States

Location

Lowry Dialysis Center

Denver, Colorado, United States

Location

Nephrology Associates, P.C.

Bridgeport, Connecticut, United States

Location

Gambro Healthcare-Hartford

Hartford, Connecticut, United States

Location

Nephrology Associates

New Britain, Connecticut, United States

Location

InterAmerican Dialysis

Coral Gables, Florida, United States

Location

DaVita Crystal River Dialysis

Crystal River, Florida, United States

Location

Gambro Healthcare-Miami

Miami, Florida, United States

Location

Miami Kidney Group

Miami, Florida, United States

Location

Pensacola Nephrology, P.A.

Pensacola, Florida, United States

Location

Gambro Healthcare-Plantation

Plantation, Florida, United States

Location

America Dialysis

St. Petersburg, Florida, United States

Location

Genesis Clinical Research Corp

Tampa, Florida, United States

Location

Gambro Healthcare-Americus

Americus, Georgia, United States

Location

nTouch Research

Atlanta, Georgia, United States

Location

Gambro Healthcare-Douglas

Douglas, Georgia, United States

Location

Gambro Healthcare-Douglasville

Douglasville, Georgia, United States

Location

Dublin Nephrology

Dublin, Georgia, United States

Location

Georgia Kidney Associates, Inc.

Marietta, Georgia, United States

Location

Gambro Healthcare-Rome

Rome, Georgia, United States

Location

Gambro Healthcare-Savannah

Savannah, Georgia, United States

Location

MacNeal Renal Lifeline Services

Berwyn, Illinois, United States

Location

Southwest Nephrology

Evergreen Park, Illinois, United States

Location

Horizon Healthcare Associates

Olympia Fields, Illinois, United States

Location

Renal Care Associates, S.C.

Peoria, Illinois, United States

Location

Gambro Healthcare-Springfield Central

Springfield, Illinois, United States

Location

Lincolnland Dialysis

Springfield, Illinois, United States

Location

Nephrology Specialists, PC.

Valparaiso, Indiana, United States

Location

Wichita Dialysis Center East

Wichita, Kansas, United States

Location

Wichita Nephrology

Wichita, Kansas, United States

Location

Northwest Louisiana Nephrology, LLC.

Shreveport, Louisiana, United States

Location

BMA of Washington

Bethesda, Maryland, United States

Location

Gambro Healthcare-Frederick

Frederick, Maryland, United States

Location

Associates in Nephrology, P.C.

Brockton, Massachusetts, United States

Location

Western New England Renal and Transplant Associates, Inc.

Springfield, Massachusetts, United States

Location

DaVita Clinical Research

Minneapolis, Minnesota, United States

Location

Nephrology Associates, P.C.

Columbus, Mississippi, 39705, United States

Location

University of Missouri-Kansas City

Kansas City, Missouri, United States

Location

DaVita Crystal City Dialysis

St Louis, Missouri, United States

Location

Nephrology and Endocrine Associates

Las Vegas, Nevada, United States

Location

Bronx Westchester Medical Group

The Bronx, New York, United States

Location

Mountain Kidney Associates, P.A.

Asheville, North Carolina, United States

Location

nTouch Research

Raleigh, North Carolina, United States

Location

Wake Nephrology/Wake Dialysis Clinic

Raleigh, North Carolina, United States

Location

Gambro Healthcare-Wilson

Wilson, North Carolina, United States

Location

Kidney and Hypertension Center

Cincinnati, Ohio, 45220, United States

Location

Ohio State University College of Pharmacy

Columbus, Ohio, United States

Location

FMC of Bethlehem

Allentown, Pennsylvania, United States

Location

Fresenius Medical Care

Greensburg, Pennsylvania, United States

Location

Hypertension and Kidney Specialists

Lancaster, Pennsylvania, United States

Location

DaVita Lewistown Dialysis Center

Lewistown, Pennsylvania, United States

Location

Albert Einstein Medical Center

Philadelphia, Pennsylvania, 19141, United States

Location

P.C. & Associates

Philadelphia, Pennsylvania, United States

Location

Nesbitt College of Pharmacy and Nursing Department of Pharmacy Practice

Wilkes-Barre, Pennsylvania, United States

Location

Gambro Healthcare-Aiken

Aiken, South Carolina, United States

Location

Midsouth Nephrology Consultants

Memphis, Tennessee, United States

Location

Dallas Nephrology Associates

Dallas, Texas, United States

Location

Nephrology, Dialysis and Transplant Association

Houston, Texas, United States

Location

West Houston Dialysis

Houston, Texas, United States

Location

San Antonio Kidney Disease Center

San Antonio, Texas, United States

Location

Gambro Healthcare - Charlottesville

Charlottesville, Virginia, 22902, United States

Location

Clinical Research and Consulting Center, LLC

Fairfax, Virginia, United States

Location

Clinical Research of Tidewater

Norfolk, Virginia, 23507, United States

Location

Virginia Commonwealth University, Division of Nephrology

Richmond, Virginia, 23298, United States

Location

Vancouver Clinic Inc., P.S.

Vancouver, Washington, United States

Location

Clinical Las Americas

San Juan, Puerto Rico

Location

Related Publications (1)

  • Natale P, Green SC, Ruospo M, Craig JC, Vecchio M, Elder GJ, Strippoli GF. Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD). Cochrane Database Syst Rev. 2025 Jun 27;6(6):CD006023. doi: 10.1002/14651858.CD006023.pub4.

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Interventions

Sevelamer

Condition Hierarchy (Ancestors)

Renal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

PolyaminesAminesOrganic Chemicals

Study Officials

  • Medical Monitor

    Genzyme, a Sanofi Company

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

May 9, 2006

First Posted

May 11, 2006

Study Start

March 1, 2001

Study Completion

February 1, 2006

Last Updated

March 18, 2015

Record last verified: 2015-03

Locations