Intermittent Versus Continuous Renal Replacement Therapy for Acute Renal Failure

NCT00322933 | Terminated

• 1 other identifier: SHARF4
• Study Type: observational
• Target: 1,628
• Locations: 1 country
• Sites: 1

Brief Summary

This multicentre SHARF4 (Stuivenberg Hospital Acute Renal Failure) study aims to investigate outcome in patients with acute renal failure (ARF), stratified according to severity of disease (SHARF score) and randomised to different treatment options. All adult patients with a serum creatinine \>2 mg/dl were included. Patients were stratified according to disease severity and those in need for RRT were randomised to intermittent (IRRT) or continuous renal replacement therapy (CRRT)

Conditions

Renal Insufficiency, Acute; Renal Replacement Therapy

Keywords

intermittent renal replacement therapy; continuous renal replacement therapy; acute renal failure; renal recovery; mortality

Interventions

renal replacement therapy (intermittent or continuous) PROCEDURE

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• adults (\>17 years)
• having acute renal failure: serum creatinine \> 2 mg/dl
• being in need for chronic renal replacement therapy (the decision to treat conservatively or to start RRT was at the discretion of the attending physician, taking into account the rules of good clinical practice in this field)

You may not qualify if:

• patients with known pre-existing chronic renal disease, defined as a serum creatinine above 1.5 mg/dl or with clearly reduced kidney size on ultrasound were excluded.

Sponsors & Collaborators

• Ziekenhuis Netwerk Antwerpen (ZNA): lead

Study Sites (1)

Robert Lins

Antwerp, 2170, Belgium

Location

Related Publications (3)

• Lins RL, Elseviers MM, Daelemans R, Arnouts P, Billiouw JM, Couttenye M, Gheuens E, Rogiers P, Rutsaert R, Van der Niepen P, De Broe ME. Re-evaluation and modification of the Stuivenberg Hospital Acute Renal Failure (SHARF) scoring system for the prognosis of acute renal failure: an independent multicentre, prospective study. Nephrol Dial Transplant. 2004 Sep;19(9):2282-8. doi: 10.1093/ndt/gfh364. Epub 2004 Jul 20.

  PMID: 15266030 BACKGROUND

• Fayad AI, Buamscha DG, Ciapponi A. Timing of kidney replacement therapy initiation for acute kidney injury. Cochrane Database Syst Rev. 2022 Nov 23;11(11):CD010612. doi: 10.1002/14651858.CD010612.pub3.

  PMID: 36416787 DERIVED

• Lins RL, Elseviers MM, Van der Niepen P, Hoste E, Malbrain ML, Damas P, Devriendt J; SHARF investigators. Intermittent versus continuous renal replacement therapy for acute kidney injury patients admitted to the intensive care unit: results of a randomized clinical trial. Nephrol Dial Transplant. 2009 Feb;24(2):512-8. doi: 10.1093/ndt/gfn560. Epub 2008 Oct 14.

  PMID: 18854418 DERIVED

MeSH Terms

Conditions

Acute Kidney Injury

Interventions

Renal Replacement Therapy

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Therapeutics

Study Officials

• Robert L Lins, MD PhD

  Ziekenhuis Netwerk Antwerpen (ZNA)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 5, 2006
• First Posted: May 8, 2006
• Study Start: April 1, 2001
• Study Completion: March 1, 2005
• Last Updated: October 26, 2006

Record last verified: 2005-04

Locations

BE (1)