Serotonin Transporter Concentrations in Women With a History of Anorexia Nervosa

NCT00320684 | Completed

• 3 other identifiers: #4625/5767RK23MH002021DATR AK-TNNS1
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This study will compare the concentrations of serotonin transporter in the brains of women with a history of anorexia nervosa who are currently maintaining a normal weight to those of healthy women of normal weight.

Conditions

Eating Disorders; Anorexia Nervosa

Keywords

Serotonin Transporter; Positron-Emission Tomography

Study Arms (2)

1

Women who have had anorexia nervosa but are now maintaining a healthy weight

2

Women who have never had anorexia nervosa and are maintaining a healthy weight

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be women who have recovered from anorexia nervosa and are currently living in the local community.

You may qualify if:

• History of anorexia nervosa
• BMI has been greater than 18.5 kg/m² for at least 9 months
• Agrees to use an effective method of contraception
• Off all psychotropic and other types of medications likely to impact the serotonin system for at least 21 days

You may not qualify if:

• Use of any psychotropic medication or other types of medications that are likely to affect the serotonin system within 21 days of study entry
• Current DSM-IV Axis-I diagnosis of any illness other than an eating disorder
• Current AN or history of AN within 9 months prior to study entry
• Presence of any psychiatric symptom that would make participation unsafe
• Significant active physical illnesses, particularly those that may affect the brain or serotonergic system, including the following: blood dyscrasias lymphomas; hypersplenism; endocrinopathies; renal failure or chronic obstructive lung disease; autonomic neuropathies; low hemoglobin; anemia; peripheral vascular disease; and malignancy
• Currently receiving effective medication treatment for an eating disorder
• History of Raynaud's phenomena and/or acrocyanosis
• Significant regular tobacco use (defined as more than 1 pack per week)
• Lacks capacity to consent
• Pregnant
• Breastfeeding
• Any metal implants, pacemaker, metal prostheses, orthodontic appliances, or the presence of shrapnel
• Significant history of claustrophobia that would complicate the completion of MRI
• Current or past radiation exposure in the workplace or as part of a research protocol in the previous year
• Badged for radiation

Sponsors & Collaborators

• New York State Psychiatric Institute: lead
• National Institute of Mental Health (NIMH): collaborator

Study Sites (1)

New York State Psychiatric Institute

New York, New York, 10032, United States

Location

Related Links

• Click here for the New York State Psychiatric Institute Eating Disorders Clinic website

MeSH Terms

Conditions

Feeding and Eating Disorders; Anorexia Nervosa

Condition Hierarchy (Ancestors)

Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Study Officials

• Evelyn Attia, MD

  New York State Psyciatric Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 1, 2006
• First Posted: May 3, 2006
• Study Start: July 1, 2003
• Primary Completion: June 1, 2009
• Study Completion: June 1, 2009
• Last Updated: July 2, 2012

Record last verified: 2012-06

Locations

US (1)