NCT00316979

Brief Summary

Migraine is a condition thought to be related to cortical hyperexcitability. Repetitive transcranial magnetic stimulation (rTMS) can modulate the cortical excitability by means of long-term potentiation or long-term depression. This study will will test the safety and efficacy of rTMS in the treatment of patients with Migraine.

Trial Health

55
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2006

Completed
19 days until next milestone

First Submitted

Initial submission to the registry

April 20, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

April 21, 2006

Completed
Last Updated

June 8, 2010

Status Verified

June 1, 2010

First QC Date

April 20, 2006

Last Update Submit

June 6, 2010

Conditions

Migraine

Keywords

migrainetranscranial magnetic stimulationrepetitive transcranial magnetic stimulationrTMS

Outcome Measures

Primary Outcomes (1)

  • Reduction in days of migraine attack per month

Secondary Outcomes (2)

  • The reduction in dosage of acute abortive medication

  • The reduction of headache index

Interventions

Repetitive Transcranial Magnetic Stimulation (rTMS)DEVICE

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age of 18-65 years
  • Diagnosed as migraine (with or without aura)
  • More than 4 attacks per month for at least 3 months prior to study
  • No preventive medication used
  • Must be able to sign permit

You may not qualify if:

  • History of seizure or family history of seizures
  • Women in pregnancy or breast-feeding
  • Patient with medication overuse
  • Patient with other medical, psychologic, or surgical illness
  • Patient under preventive medications
  • Prior rTMS examination one month within

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Headache Center, Teipei Veterans General Hospital

Taipei, 112, Taiwan

RECRUITING

Related Publications (2)

  • Brighina F, Piazza A, Vitello G, Aloisio A, Palermo A, Daniele O, Fierro B. rTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study. J Neurol Sci. 2004 Dec 15;227(1):67-71. doi: 10.1016/j.jns.2004.08.008.

    PMID: 15546593BACKGROUND

  • Lorenz J, Minoshima S, Casey KL. Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain. 2003 May;126(Pt 5):1079-91. doi: 10.1093/brain/awg102.

    PMID: 12690048BACKGROUND

MeSH Terms

Conditions

Migraine Disorders

Interventions

Transcranial Magnetic Stimulation

Condition Hierarchy (Ancestors)

Headache Disorders, PrimaryHeadache DisordersBrain DiseasesCentral Nervous System DiseasesNervous System Diseases

Intervention Hierarchy (Ancestors)

Magnetic Field TherapyTherapeutics

Study Officials

  • Shuu-Jiun Wang, MD

    Headache Center, Taipei Veterans General Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Shuu-Jiun Wang, MD

CONTACT

+886-2-28712121sjwang@vghtpe.gov.tw

Kuan-Lin Lai, MD

CONTACT

+886-2-28712121kllai@vghtpe.gov.tw

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER GOV

Study Record Dates

First Submitted

April 20, 2006

First Posted

April 21, 2006

Study Start

April 1, 2006

Last Updated

June 8, 2010

Record last verified: 2010-06

Locations

TW(1)