Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease and/ or Hypertension

NCT00313430 | Completed

• 1 other identifier: MED. RES.HOS 2004 03/IT
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators want to test the hypothesis that patients with chronic renal disease have a poorer ability to preserve water after being thirsty and a poorer ability to excrete water after a load of fluid. They presume that these abilities become poorer when renal insufficiency progresses. The investigators further hypothesize that patients with hypertension also have a decreased ability to concentrate and dilute urine.

Conditions

Renal Insufficiency, Chronic; Hypertension

Keywords

Urine concentration ability; chronic renal insufficiency; hypertension; aquaporin2; Patients with chronic renal insufficiency; Patients with hypertension; Healthy volunteers

Study Arms (2)

Dialysis patients

with or wthout glucose added to dialysis fluid

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy participants were recruited by advertisements in public and private institutions Patients with primary hypertension or chronic renal failure were recruited from the Out-patients' Clinic, Department of Medicine, Section of Nephrology, Holstebro Hospital

You may qualify if:

• Patients with chronic renal insufficiency, aged between 18 and 65, both men and women
• Creatinine clearance between 30-59 ml/min
• Patients with hypertension, aged between 18 and 65, both men and women; hypertension is defined as a mean arterial blood pressure in the daytime that is more than 140/90 mm Hg.
• Healthy volunteers, aged between 18 and 65, both men and women

You may not qualify if:

• Clinical signs or history of disease in the heart, lungs, liver, brain, and endocrine organs
• Cancer
• Alcohol abuse
• Medicine abuse
• Pregnancy

Sponsors & Collaborators

• Erling Bjerregaard Pedersen: lead

Study Sites (1)

Department of Medicine, Holstebro Hospital

Holstebro, Ringkjoebing, 7500, Denmark

Location

Related Publications (1)

• Pedersen EB, Thomsen IM, Lauridsen TG. Abnormal function of the vasopressin-cyclic-AMP-aquaporin2 axis during urine concentrating and diluting in patients with reduced renal function. A case control study. BMC Nephrol. 2010 Oct 5;11:26. doi: 10.1186/1471-2369-11-26.

  PMID: 20923561 DERIVED

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Hypertension

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Erling B Pedersen, Professor

  Holstebro, Holstebro, Denmark

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: professor, chief physician

Study Record Dates

• First Submitted: April 11, 2006
• First Posted: April 12, 2006
• Study Start: May 1, 2004
• Primary Completion: March 1, 2008
• Last Updated: August 21, 2015

Record last verified: 2015-08

Locations

DK (1)