NCT00312806

Brief Summary

The aim of the present study is to identify factors (such as symptom patterns and symptom scores) that influence the response to treatment with pantoprazole using different evaluation methods (e.g., ReQuest™ questionnaire, patient and investigator assessment). Pantoprazole will be administered once daily in the morning at one dose level. The study duration consists of a treatment period of 8 weeks. The study will provide further data on safety and tolerability of pantoprazole.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
2,000

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started May 2006

Shorter than P25 for phase_3

Geographic Reach
21 countries

174 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 10, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

April 11, 2006

Completed
20 days until next milestone

Study Start

First participant enrolled

May 1, 2006

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2007

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2007

Completed
Last Updated

May 7, 2012

Status Verified

December 1, 2008

Enrollment Period

10 months

First QC Date

April 10, 2006

Last Update Submit

May 4, 2012

Conditions

Keywords

Gastroesophageal Reflux DiseaseGERDPantoprazoleReQuestTM

Outcome Measures

Primary Outcomes (1)

  • Response to treatment with pantoprazole at week 8, as measured by the questionnaire ReQuest™

    8 weeks

Secondary Outcomes (3)

  • Response to treatment with pantoprazole at week 4, as measured by the questionnaire ReQuest™

    4 and 8 weeks

  • Investigator assessment

    4 and 8 weeks

  • Safety and efficacy

    4 and 8 weeks

Interventions

Pantoprazole 40 mg o.d.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Written informed consent
  • Outpatients of at least 18 years (21 years in Argentina)
  • Patient considered to have GERD symptoms

You may not qualify if:

  • Acute peptic ulcer and/or ulcer complications
  • Systemic glucocorticoids or non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2-inhibitors (\> 5 days on demand but not more than 3 consecutive days) during the last 28 days before study start (except regular intake of acetylsalicylic acid at a dose up to 163 mg/day)
  • Intake of proton pump inhibitors during the last 10 days before study start
  • Female patients of childbearing potential not using adequate means of birth control
  • Pregnant or breast-feeding females

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (186)

Altana Pharma/Nycomed

Buenos Aires, 1161, Argentina

Location

Altana Pharma/Nycomed

Buenos Aires, 1405, Argentina

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Altana Pharma/Nycomed

Buenos Aires, Argentina

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Altana Pharma/Nycomed

La Plata, 1900, Argentina

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Altana Pharma/Nycomed

Bedford Park SA, 5042, Australia

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Altana Pharma/Nycomed

Bondi Junction, NSW 2022, Australia

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Altana Pharma/Nycomed

Fitzroy, VIC 3065, Australia

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Altana Pharma/Nycomed

Footscray, VIC 3011, Australia

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Altana Pharma/Nycomed

Fremantle, WA, 6959, Australia

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Altana Pharma/Nycomed

Kippa_ring, QLD 4021, Australia

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Altana Pharma/Nycomed

Melbourne, VIC 3050, Australia

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Altana Pharma/Nycomed

NSW, 2310, Australia

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Altana Pharma/Nycomed

Penrith, NSW, Australia

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Altana Pharma/Nycomed

Phrahran, VIC 3181, Australia

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Altana Pharma/Nycomed

Deutschlandsberg, 8539, Austria

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Altana Pharma/Nycomed

Feldbach, 8330, Austria

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Altana Pharma/Nycomed

Graz, 8010, Austria

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Altana Pharma/Nycomed

Krems A. D. Donau, 3500, Austria

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Altana Pharma/Nycomed

Lilienfeld, 3180, Austria

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Altana Pharma/Nycomed

Sankt Pölten, 3100, Austria

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Altana Pharma/Nycomed

Vienna, 1100, Austria

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Altana Pharma/Nycomed

Vienna, 1130, Austria

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Altana Pharma/Nycomed

Vienna, 1140, Austria

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Altana Pharma/Nycomed

Vienna, 1160, Austria

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Altana Pharma/Nycomed

Vienna, 1170, Austria

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Altana Pharma/Nycomed

Vienna, 1220, Austria

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Altana Pharma/Nycomed

Bouge, 5004, Belgium

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Altana Pharma/Nycomed

Brussels, 1000, Belgium

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Altana Pharma/Nycomed

Brussels, 1020, Belgium

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Altana Pharma/Nycomed

Brussels, 1040, Belgium

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Altana Pharma/Nycomed

Brussels, 1070, Belgium

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Altana Pharma/Nycomed

Edegem, 2650, Belgium

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Altana Pharma/Nycomed

Eupen, 4700, Belgium

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Altana Pharma/Nycomed

Ghent, 9000, Belgium

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Altana Pharma/Nycomed

Jette, 1090, Belgium

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Altana Pharma/Nycomed

Kortrijk, 8500, Belgium

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Altana Pharma/Nycomed

Leuven, 3000, Belgium

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Altana Pharma/Nycomed

Merksem, 2170, Belgium

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Altana Pharma/Nycomed

Ostend, 8400, Belgium

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Altana Pharma/Nycomed

Saint Niklaas, 9100, Belgium

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Altana Pharma/Nycomed

Sart-Tilman/Liege 1, 4000, Belgium

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Altana Pharma/Nycomed

Belo Horizonte - Minas Gerais, 30130100, Brazil

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Altana Pharma/Nycomed

Botucatu - SP CEP, 16618000, Brazil

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Altana Pharma/Nycomed

Campinas - Sao Paulo, 13070040, Brazil

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Altana Pharma/Nycomed

Campinas /SP, Brazil

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Altana Pharma/Nycomed

Curitiba-PR, 80060900, Brazil

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Altana Pharma/Nycomed

Ilha Do Fundao - Rio de Janeiro - RJ, 21941590, Brazil

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Altana Pharma/Nycomed

Pinheiros Sao Paulo - SP, 1246-000, Brazil

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Altana Pharma/Nycomed

Porto Alegre, Brazil

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Altana Pharma/Nycomed

Porto Alegre - RS, 90035003, Brazil

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Altana Pharma/Nycomed

Porto Alegre-RS, 90020090, Brazil

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Altana Pharma/Nycomed

Ribeirao Preto-SP, 14048900, Brazil

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Altana Pharma/Nycomed

Abbotsford, BC, V2S 3N5, Canada

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Altana Pharma/Nycomed

Calgary, T2N 4N1, Canada

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Altana Pharma/Nycomed

Hamilton, L8N 4A6, Canada

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Altana Pharma/Nycomed

London, N6A 4G5, Canada

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Altana Pharma/Nycomed

Montreal, H3G 1A4, Canada

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Altana Pharma/Nycomed

Montreal, QC, H3A 1A1, Canada

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Altana Pharma/Nycomed

Québec, H9R 3J1, Canada

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Altana Pharma/Nycomed

St.-Charles Borromee, QC, J6E 2C3, Canada

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Altana Pharma/Nycomed

Ste Foy, G1S 4L8, Canada

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Altana Pharma/Nycomed

Toronto, M3N 2V7, Canada

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Altana Pharma/Nycomed

Toronto, M5B 1W8, Canada

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Altana Pharma/Nycomed

Windsor, N9A 1C9, Canada

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Altana Pharma/Nycomed

Winnipeg, R3A 1R9, Canada

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Altana Pharma/Nycomed

Agen, 47000, France

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Altana Pharma/Nycomed

Bobigny, 93000, France

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Altana Pharma/Nycomed

Hagondange, 57300, France

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Altana Pharma/Nycomed

Joué-lès-Tours, 37300, France

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Altana Pharma/Nycomed

Lamballe, 22400, France

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Altana Pharma/Nycomed

Marseille, 13013, France

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Altana Pharma/Nycomed

Metz, 57000, France

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Altana Pharma/Nycomed

Orthez, 64300, France

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Altana Pharma/Nycomed

Saint-Mandé, 94160, France

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Altana Pharma/Nycomed

Toul, 54200, France

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Altana Pharma/Nycomed

Toulouse, 31000, France

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Altana Pharma/Nycomed

Troyes, 10000, France

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Altana Pharma/Nycomed

Bonn, 53173, Germany

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Altana Pharma/Nycomed

Burg, 39288, Germany

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Altana Pharma/Nycomed

Gardelegen, 39638, Germany

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Altana Pharma/Nycomed

Heilbronn, 74081, Germany

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Altana Pharma/Nycomed

Hennef (Sieg), 53773, Germany

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Altana Pharma/Nycomed

Ludwigsburg, 71640, Germany

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Altana Pharma/Nycomed

Lübeck, 23552, Germany

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Altana Pharma/Nycomed

Magdeburg, 39130, Germany

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Altana Pharma/Nycomed

Schwerin, 19053, Germany

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Altana Pharma/Nycomed

Hong Kong, Hong Kong

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Altana Pharma/Nycomed

Coimbatore, 641004, India

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Altana Pharma/Nycomed

Coimbatore, 641018, India

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Altana Pharma/Nycomed

Hyderabad, 500082, India

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Altana Pharma/Nycomed

Jaipur, India

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Altana Pharma/Nycomed

Madurai, 625002, India

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Altana Pharma/Nycomed

Mumbai, 400 008, India

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Altana Pharma/Nycomed

Mumbai, 400022, India

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Altana Pharma/Nycomed

Mysore, 570020, India

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Altana Pharma/Nycomed

Nagpur, 12, India

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Altana Pharma/Nycomed

Pune, 411 030, India

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Altana Pharma/Nycomed

Pune, 411004, India

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Altana Pharma/Nycomed

Aviano (Pordenone), 33081, Italy

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Altana Pharma/Nycomed

Bari, 70124, Italy

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Altana Pharma/Nycomed

Caserta, 81100, Italy

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Altana Pharma/Nycomed

Catania, 95123, Italy

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Altana Pharma/Nycomed

Genova, 16132, Italy

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Altana Pharma/Nycomed

Mestre (VE), 30174, Italy

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Altana Pharma/Nycomed

Milan, 20147, Italy

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Altana Pharma/Nycomed

Napoli, 80131, Italy

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Altana Pharma/Nycomed

Parma, 43100, Italy

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Altana Pharma/Nycomed

Roma, 133, Italy

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Altana Pharma/Nycomed

Roma, 135, Italy

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Altana Pharma/Nycomed

Roma, 189, Italy

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Altana Pharma/Nycomed

Rozzano (Milano), 20089, Italy

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Altana Pharma/Nycomed

Kota Kinabalu, Sabah, 88586, Malaysia

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Altana Pharma/Nycomed

Kuala Lumpur, 50603, Malaysia

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Altana Pharma/Nycomed

Col Del Valle, México D.F., 3100, Mexico

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Altana Pharma/Nycomed

Col Del Valle, México D.F., 6760, Mexico

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Altana Pharma/Nycomed

Col Héroes de Padierna, México D.F., 10700, Mexico

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Altana Pharma/Nycomed

Col. Altavista,Tampico Tamaulipas,Mexico, 89240, Mexico

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Altana Pharma/Nycomed

Col. Ex Hacienda Coapa Mexico D.F., 4860, Mexico

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Altana Pharma/Nycomed

Héroes de Padierna, México D.F., 3100, Mexico

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Altana Pharma/Nycomed

León, Guanajuato Mexico, 36000, Mexico

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Altana Pharma/Nycomed

León, Guanajuato, 37320, Mexico

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Altana Pharma/Nycomed

Lomas de Chapultepec, México D.F., 11000, Mexico

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Altana Pharma/Nycomed

México, D.F., 3100, Mexico

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Altana Pharma/Nycomed

Villahermosa, Tabasco, 86000, Mexico

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Altana Pharma/Nycomed

Villahermosa, Tabasco, 86085, Mexico

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Altana Pharma/Nycomed

Bialystok, 15-276, Poland

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Altana Pharma/Nycomed

Katowice, 40-752, Poland

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Altana Pharma/Nycomed

Lodz, 90-153, Poland

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Altana Pharma/Nycomed

Warsaw, 02-097, Poland

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Altana Pharma/Nycomed

Warsaw, 02-507, Poland

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Altana Pharma/Nycomed

Amadora, 2720-276, Portugal

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Altana Pharma/Nycomed

Carnaxide, 2799-523, Portugal

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Altana Pharma/Nycomed

Coimbra, 3001, Portugal

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Altana Pharma/Nycomed

Lisbon, 1099-023, Portugal

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Altana Pharma/Nycomed

Lisbon, 1349-019, Portugal

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Altana Pharma/Nycomed

Lisbon, 1769-053, Portugal

Location

Altana Pharma/Nycomed

Santarém, 2005-177, Portugal

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Altana Pharma/Nycomed

Setúbal, 2910-446, Portugal

Location

Altana Pharma/Nycomed

Viana do Castelo, 4900-858, Portugal

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Altana Pharma/Nycomed

Vila Nova de Gaia, 4400-346, Portugal

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Altana Pharma/Nycomed

Singapore, 1699608, Singapore

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Altana Pharma/Nycomed

Berea, Durban, 4000, South Africa

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Altana Pharma/Nycomed

Bloemfontein, 9317, South Africa

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Altana Pharma/Nycomed

Cape Town, 7530, South Africa

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Altana Pharma/Nycomed

eManzimtoti, 4126, South Africa

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Altana Pharma/Nycomed

Panorama, 7500, South Africa

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Altana Pharma/Nycomed

Port Elizabeth, 6001, South Africa

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Altana Pharma/Nycomed

Pretoria, 48, South Africa

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Altana Pharma/Nycomed

Somerset West, 7130, South Africa

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Altana Pharma/Nycomed

Seoul, 110-744, South Korea

Location

Altana Pharma/Nycomed

Seoul, 135-710, South Korea

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Altana Pharma/Nycomed

Seoul, 135-720, South Korea

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Altana Pharma/Nycomed

Seoul, 137-040, South Korea

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Altana Pharma/Nycomed

Seoul, 138-736, South Korea

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Altana Pharma/Nycomed

Barcelona, 8017, Spain

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Altana Pharma/Nycomed

Barcelona, 8222, Spain

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Altana Pharma/Nycomed

Cadiz, 11009, Spain

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Altana Pharma/Nycomed

Castellon, 12004, Spain

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Altana Pharma/Nycomed

Córdoba, 14004, Spain

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Altana Pharma/Nycomed

Granada, 18014, Spain

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Altana Pharma/Nycomed

Madrid, 28035, Spain

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Altana Pharma/Nycomed

Madrid, 28046, Spain

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Altana Pharma/Nycomed

Madrid, 28200, Spain

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Altana Pharma/Nycomed

Pamplona, 31080, Spain

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Altana Pharma/Nycomed

Ribeira, 15993, Spain

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Altana Pharma/Nycomed

Seville, 41014, Spain

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Altana Pharma/Nycomed

Basel, 4031, Switzerland

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Altana Pharma/Nycomed

Biasca, 6710, Switzerland

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Altana Pharma/Nycomed

Biel/Bienne, 2502, Switzerland

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Altana Pharma/Nycomed

Lausanne 11 VD, 1011, Switzerland

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Altana Pharma/Nycomed

Liestal, 4410, Switzerland

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Altana Pharma/Nycomed

Locarno, TI., 6600, Switzerland

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Altana Pharma/Nycomed

Lucerne, 6003, Switzerland

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Altana Pharma/Nycomed

Payerne, 1530, Switzerland

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Altana Pharma/Nycomed

Thun, 3600, Switzerland

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Altana Pharma/Nycomed

Zurich, 8002, Switzerland

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Altana Pharma/Nycomed

Zurich, 8050, Switzerland

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Altana Pharma/Nycomed

Taichung, 40705, Taiwan

Location

Altana Pharma/Nycomed

Tainan, 701, Taiwan

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Altana Pharma/Nycomed

Taipei, Taiwan

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Altana Pharma/Nycomed

Bath, BA1 2SR, United Kingdom

Location

Altana Pharma/Nycomed

Blackpool, FY3 7EN, United Kingdom

Location

Altana Pharma/Nycomed

Glasgow, G45 9AW, United Kingdom

Location

Altana Pharma/Nycomed

Middlesex, HA6 2RN, United Kingdom

Location

Altana Pharma/Nycomed

Sheffield, S5 7QB, United Kingdom

Location

Altana Pharma/Nycomed

Trowbridge, BA14 9AR, United Kingdom

Location

Related Publications (2)

  • Goh KL, Choi KD, Choi MG, Hsieh TY, Jung HY, Lien HC, Menon J, Mesenas S, Park H, Sheu BS, Wu JC. Factors influencing treatment outcome in patients with gastroesophageal reflux disease: outcome of a prospective pragmatic trial in Asian patients. BMC Gastroenterol. 2014 Sep 9;14:156. doi: 10.1186/1471-230X-14-156.

  • Heading RC, Monnikes H, Tholen A, Schmitt H. Prediction of response to PPI therapy and factors influencing treatment outcome in patients with GORD: a prospective pragmatic trial using pantoprazole. BMC Gastroenterol. 2011 May 11;11:52. doi: 10.1186/1471-230X-11-52.

MeSH Terms

Conditions

Gastroesophageal Reflux

Interventions

Pantoprazole

Condition Hierarchy (Ancestors)

Esophageal Motility DisordersDeglutition DisordersEsophageal DiseasesGastrointestinal DiseasesDigestive System Diseases

Intervention Hierarchy (Ancestors)

2-PyridinylmethylsulfinylbenzimidazolesSulfoxidesSulfur CompoundsOrganic ChemicalsPyridinesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsBenzimidazolesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-Ring

Study Officials

  • Hans-Joachim Ulmer, MD

    Medical practice, D-71640 Ludwigsburg, Germany

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

April 10, 2006

First Posted

April 11, 2006

Study Start

May 1, 2006

Primary Completion

March 1, 2007

Study Completion

July 1, 2007

Last Updated

May 7, 2012

Record last verified: 2008-12

Locations