Emphysema Research Registry and Biosample Repository

NCT00307281 | Recruiting

• 2 other identifiers: STUDY19120059ERC Registry
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

The Comprehensive Lung Center (CLC) at the University of Pittsburgh Medical Center (UPMC Health System) provides patients with any type of breathing or lung disorder a full range of diagnostic and therapeutic services. The Emphysema/COPD Research Center (ECRC) is a specialty clinic, within this center, that attempts to advance the understanding of emphysema and to evaluate new therapies for patients with emphysema. The Emphysema Research Registry will enable pulmonary research physicians to: 1) gather information and create a research registry of people who have been diagnosed with emphysema; 2) utilize this research registry with the purpose of conducting research that attempts to advance the understanding of emphysema and to evaluate new therapies; and, 3) use the research registry to identify potential candidates for future research programs. These aims will be achieved by the collection of DNA (genetic material)for analysis and storage in addition to pulmonary function tests and other medical information.

Conditions

Emphysema; Chronic Obstructive Pulmonary Disease; Chronic Bronchitis

Outcome Measures

Primary Outcomes (1)

• To gather information and create a research registry of people who have been diagnosed with emphysema and a control cohort of research participants without lung diseases,

  This research registry will allow us to to advance the understanding of emphysema and to evaluate new therapies for patients with emphysema.

  Indefinite

Secondary Outcomes (1)

• To continue communications with past, present, and future research participants.

  Indefinite

Study Arms (1)

Registry

10 pack year tobacco smoking history required, current or former smokers accepted.

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Current and former smokers with a 10 pack year tobacco history.

You may qualify if:

• Patients would be required to have COPD based on at least one of the following: clinical history, pulmonary function results, or radiographic results.

You may not qualify if:

• none

Sponsors & Collaborators

• University of Pittsburgh: lead

Study Sites (1)

University of Pittsburgh Emphysema/COPD Research Center

Pittsburgh, Pennsylvania, 15213, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

The DNA studies that will be done as a part of this study will be restricted to/used for studies of genetics associated with COPD. Optional Alpha-1 Antitrypsin swab testing will also be performed on COPD subjects. Specimens will assigned a study ID#

MeSH Terms

Conditions

Emphysema; Pulmonary Disease, Chronic Obstructive; Bronchitis, Chronic

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Bronchitis; Respiratory Tract Infections; Infections; Bronchial Diseases

Study Officials

• Frank C. Sciurba, MD

  University of Pittsburgh Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Paula Consolaro, CCRC

CONTACT

412-692-4800; consolaropj@upmc.edu

Vera Iouchmanov, BS

CONTACT

412-864-3052; iouchmanovvl@upmc.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director, Emphysema/COPD Research Center

Study Record Dates

• First Submitted: March 24, 2006
• First Posted: March 27, 2006
• Study Start: August 1, 2000
• Primary Completion (Estimated): July 1, 2030
• Study Completion (Estimated): July 1, 2030
• Last Updated: September 25, 2025

Record last verified: 2025-09

Locations

US (1)