Moderate Alcohol Consumption, Risk of Cardiovascular Disease and Type 2 Diabetes: Influence of Alcohol Oxidation

NCT00285909 | Completed

• 2 other identifiers: P6689Alcohol research 20
• Study Type: interventional
• Target: 36
• Locations: 0 countries
• Sites: N/A

Brief Summary

Moderate alcohol consumption is associated with a decreased risk of cardiovascular disease and type 2 diabetes. The association of alcohol consumption with cardiovascular disease is mediated by a functional polymorphism of alcohol dehydrogenase 1c, but the effect of this polymorphism on alcohol metabolism is only investigated in vitro. The risk reduction of moderate alcohol consumption for cardiovascular disease is explained largely by an increase of HDL cholesterol, but an increase of adiponectin concentrations after moderate alcohol consumption may also be involved. It seems likely that adiponectin is a mediator for the association of moderate alcohol consumption with type 2 diabetes. The mechanism by which moderate alcohol consumption increases adiponectin concentrations is unknown, but ppar-gamma activation may be involved. effects of this polymorphism on mediators of this relation are not known. This study therefore investigates the effect of moderate alcohol consumption and the influence of alcohol dehydrogenase 1c polymorphism on ppar-gamma activated gene expression and risk factors of cardiovascular disease and type 2 diabetes.

Conditions

Cardiovascular Disease; Type 2 Diabetes

Keywords

Moderate alcohol consumption; Alcohol dehydrogenase 1c polymorphism; PPAR-gamma activated gene expression

Outcome Measures

Primary Outcomes (1)

• PPAR-gamma activated gene expression

Secondary Outcomes (2)

• Risk factors of cardiovascular disease and type 2 diabetes

• Postprandial changes of HPA-axis activity

Interventions

Alcohol: 25 gday (white wine) BEHAVIORAL

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy women aged 40 to 65 years
• Absence of menstrual period for at least 2 years
• Homozygotes for the ADH1C\*1 or ADH1C\*2 allele of ADH1C I349V polymorphism
• Alcohol consumption ≥ 5 and ≤ 21 units/week

You may not qualify if:

• Smoking
• Family history of alcoholism
• History of medical or surgical events that may significantly affect the study outcome, particularly metabolic or endocrine disorders and gastrointestinal disorders
• Recent blood donation

Sponsors & Collaborators

• TNO: lead

Related Publications (2)

• Joosten MM, Schrieks IC, Hendriks HF. Effect of moderate alcohol consumption on fetuin-A levels in men and women: post-hoc analyses of three open-label randomized crossover trials. Diabetol Metab Syndr. 2014 Feb 18;6(1):24. doi: 10.1186/1758-5996-6-24.

  PMID: 24548643 DERIVED

• Joosten MM, Beulens JW, Kersten S, Hendriks HF. Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomised, crossover trial. Diabetologia. 2008 Aug;51(8):1375-81. doi: 10.1007/s00125-008-1031-y. Epub 2008 May 27.

  PMID: 18504547 DERIVED

MeSH Terms

Conditions

Cardiovascular Diseases; Diabetes Mellitus, Type 2

Interventions

Ethanol

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Alcohols; Organic Chemicals

Study Officials

• Henk FJ Hendriks, PhD.

  TNO

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 31, 2006
• First Posted: February 2, 2006
• Study Start: March 1, 2006
• Study Completion: June 1, 2006
• Last Updated: August 16, 2006

Record last verified: 2006-08