NCT00281554

Brief Summary

This study is designed to determine the safety of RSD1235 in patients with atrial fibrillation.

Trial Health

93
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
254

participants targeted

Target at P50-P75 for phase_3 atrial-fibrillation

Timeline
Completed

Started Oct 2005

Shorter than P25 for phase_3 atrial-fibrillation

Geographic Reach
6 countries

40 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2005

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

January 24, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

January 25, 2006

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2007

Completed
Last Updated

April 3, 2008

Status Verified

April 1, 2008

Enrollment Period

1.3 years

First QC Date

January 24, 2006

Last Update Submit

April 1, 2008

Conditions

Keywords

Investigational TherapiesAtrial FibrillationTreatment EfficacyTreatment EffectivenessSafetyRSD1235

Outcome Measures

Primary Outcomes (1)

  • Rate of conversion of atrial fibrillation to sinus rhythm for a minimum of 1 minute

    Infusion plus 1.5 hours

Secondary Outcomes (1)

  • Evaluate safety

    End of study

Study Arms (1)

1

EXPERIMENTAL
Drug: RSD1235

Interventions

IV

Also known as: vernakalant, Kynapid
1

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Subject must have symptomatic AF
  • Subject must have adequate anticoagulant therapy

You may not qualify if:

  • Subject may not have Class IV congestive heart failure.
  • Subject may not have uncorrected electrolyte imbalance.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (40)

Unknown Facility

Huntsville, Alabama, 35801, United States

Location

Unknown Facility

Atlanta, Georgia, 30322, United States

Location

Unknown Facility

Chicago, Illinois, 60637, United States

Location

Unknown Facility

Oak Lawn, Illinois, 60453, United States

Location

Unknown Facility

Boston, Massachusetts, 02135, United States

Location

Unknown Facility

Lansing, Michigan, 48910, United States

Location

Unknown Facility

Austin, Texas, 78756, United States

Location

Unknown Facility

San Antonio, Texas, 78229, United States

Location

Unknown Facility

Richmond, Virginia, 23249, United States

Location

Unknown Facility

Marshfield, Wisconsin, 54449, United States

Location

Unknown Facility

Buenos Aires, B8185SAN, Argentina

Location

Unknown Facility

Buenos Aires, C1064AAR, Argentina

Location

Unknown Facility

Buenos Aires, C1406GZL, Argentina

Location

Unknown Facility

Buenos Aires, CP1280, Argentina

Location

Unknown Facility

Buenos Aires, CP1437, Argentina

Location

Unknown Facility

Corrientes, CP3400, Argentina

Location

Unknown Facility

De Buenos Aires, Argentina

Location

Unknown Facility

Rosario, Argentina

Location

Unknown Facility

Tulunaw, CP4000, Argentina

Location

Unknown Facility

Calgary, Alberta, T2N 4N1, Canada

Location

Unknown Facility

Ottawa, Ontario, K1Y 4E9, Canada

Location

Unknown Facility

Montreal, Quebec, G2K 4N1, Canada

Location

Unknown Facility

Montreal, Quebec, H2W 1T8, Canada

Location

Unknown Facility

Terrebonne, Quebec, J6V 2H2, Canada

Location

Unknown Facility

Aalborg, DK-9000, Denmark

Location

Unknown Facility

Esbjerg, DK-9800, Denmark

Location

Unknown Facility

Hjørring, DK-9800, Denmark

Location

Unknown Facility

Hvidovre, DK-2650, Denmark

Location

Unknown Facility

København NV, DK-2400, Denmark

Location

Unknown Facility

Køge, 4600, Denmark

Location

Unknown Facility

Berea Durban, 4001, South Africa

Location

Unknown Facility

Bloemfontein, 9301, South Africa

Location

Unknown Facility

Centurion, 0157, South Africa

Location

Unknown Facility

Parow, 7500, South Africa

Location

Unknown Facility

Somerset West, 7130, South Africa

Location

Unknown Facility

Westdene Bloemfontein, 9301, South Africa

Location

Unknown Facility

Malmo, SE-205-02, Sweden

Location

Unknown Facility

Mölndal, SE-431-80, Sweden

Location

Unknown Facility

Örebro, SE-701-85, Sweden

Location

Unknown Facility

Stockholm, SE-182-88, Sweden

Location

Related Publications (2)

  • Stiell IG, Dickinson G, Butterfield NN, Clement CM, Perry JJ, Vaillancourt C, Calder LA. Vernakalant hydrochloride: A novel atrial-selective agent for the cardioversion of recent-onset atrial fibrillation in the emergency department. Acad Emerg Med. 2010 Nov;17(11):1175-82. doi: 10.1111/j.1553-2712.2010.00915.x.

  • Stiell IG, Roos JS, Kavanagh KM, Dickinson G. A multicenter, open-label study of vernakalant for the conversion of atrial fibrillation to sinus rhythm. Am Heart J. 2010 Jun;159(6):1095-101. doi: 10.1016/j.ahj.2010.02.035.

MeSH Terms

Conditions

Atrial Fibrillation

Interventions

vernakalant

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Use Central Contact

    Astellas Pharma US, Inc.

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

January 24, 2006

First Posted

January 25, 2006

Study Start

October 1, 2005

Primary Completion

January 1, 2007

Study Completion

January 1, 2007

Last Updated

April 3, 2008

Record last verified: 2008-04

Locations