Non-invasive Diagnosis of Coronary Artery Stenoses by Doppler Echocardiography

NCT00281346 | Completed

• 1 other identifier: 29 FU-71-05
• Study Type: interventional
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

Non-invasive evaluation of patients with stable angina and unstable coronary syndromes with transthoracic Doppler echocardiography to evaluate presence of significant coronary stenoses. Blinded evaluation and comparison with coronary angiography: presence and location of stenoses, and head to head comparison of clinical value and patient classification.

Conditions

Stable Angina Pectoris; Unstable Angina Pectoris; Acute Myocardial Infarction

Keywords

Doppler echocardiography; coronary stenosis; Coronary angiography

Outcome Measures

Primary Outcomes (2)

• Diagnostic yield: Accuracy, positive and negative predictive value.

  Inhospital

• pr patient evaluation

  Inhospital

Secondary Outcomes (1)

• pr stenosis evaluation

  Inhospital

Study Arms (1)

transthoracic Doppler echocardiography

EXPERIMENTAL

Procedure: Doppler echocardiography

Interventions

Doppler echocardiography PROCEDURE

Echocardiography

transthoracic Doppler echocardiography

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• unstable angina or acute myocardial infarction, or stable angina pectoris and
• scheduled for coronary angiography on accepted clinical reasons

You may not qualify if:

• past coronary artery grafting

Sponsors & Collaborators

• Norwegian University of Science and Technology: lead

Study Sites (1)

Ålesund Hospital HF

Ålesund, N-6026, Norway

Location

Related Publications (4)

• Holte E, Vegsundvag J, Hegbom K, Hole T, Wiseth R. Transthoracic Doppler for detection of stenoses in the three main coronary arteries by use of stenotic to prestenotic velocity ratio and aliased coronary flow. Eur Heart J Cardiovasc Imaging. 2015 Dec;16(12):1323-30. doi: 10.1093/ehjci/jev158. Epub 2015 Jun 25.

  PMID: 26113119 RESULT

• Vegsundvag J, Holte E, Wiseth R, Hegbom K, Hole T. Coronary artery occlusions diagnosed by transthoracic Doppler. Cardiovasc Ultrasound. 2014 Mar 15;12:12. doi: 10.1186/1476-7120-12-12.

  PMID: 24628779 DERIVED

• Vegsundvag J, Holte E, Wiseth R, Hegbom K, Hole T. Coronary flow velocity reserve in the three main coronary arteries assessed with transthoracic Doppler: a comparative study with quantitative coronary angiography. J Am Soc Echocardiogr. 2011 Jul;24(7):758-67. doi: 10.1016/j.echo.2011.03.010. Epub 2011 Apr 23.

  PMID: 21524564 DERIVED

• Vegsundvag J, Holte E, Wiseth R, Hegbom K, Hole T. Transthoracic echocardiography for imaging of the different coronary artery segments: a feasibility study. Cardiovasc Ultrasound. 2009 Dec 22;7:58. doi: 10.1186/1476-7120-7-58.

  PMID: 20028530 DERIVED

MeSH Terms

Conditions

Angina, Stable; Angina, Unstable; Coronary Stenosis

Condition Hierarchy (Ancestors)

Angina Pectoris; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Chest Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Coronary Disease

Study Officials

• Torstein L Hole, MD, PhD

  Norwegian University of Science and Technology

  STUDY CHAIR

• Johnny Å Vegsundvåg, MD

  PRINCIPAL INVESTIGATOR

• Rune Wiseth, MD, PhD

  Norwegian University of Science and Technology

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 23, 2006
• First Posted: January 24, 2006
• Study Start: December 1, 2005
• Primary Completion: January 1, 2008
• Study Completion: August 1, 2008
• Last Updated: July 18, 2016

Record last verified: 2016-07

Locations

NO (1)