Blood Sugars in Children With Idiopathic Seizures.

NCT00279851 | Withdrawn

• 1 other identifier: 05046
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine if there is a significant percentage of children with the diagnosis of idiopathic seizures who have undiagnosed or unrecognized hypoglycemia (low blood sugar).

Conditions

Seizures; Hypoglycemia; Hyperammonemia

Keywords

idiopathic seizure; hypoglycemia; hyperammonemia/hyperinsulinism syndrome

Eligibility Criteria

• Age: Up to 17 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Patients with idiopathic seizure disorders under age 18 years of age.

You may qualify if:

• The age range will be from birth to 17 years of age.
• Study subjects may be on anti-convulsants; the study does not alter current drug therapy.

You may not qualify if:

• congenital causes (CNS malformation, cerebral palsy)
• CNS infection toxic/known metabolic abnormality
• CNS neoplasm perinatal insults (birth trauma, asphyxia/hypoxia),
• traumatic
• All others who have an anatomic or known biochemical lesion.

Sponsors & Collaborators

• Children's Mercy Hospital Kansas City: lead

Study Sites (1)

Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108, United States

Location

Related Publications (12)

• Hsu BY, Kelly A, Thornton PS, Greenberg CR, Dilling LA, Stanley CA. Protein-sensitive and fasting hypoglycemia in children with the hyperinsulinism/hyperammonemia syndrome. J Pediatr. 2001 Mar;138(3):383-9. doi: 10.1067/mpd.2001.111818.

  PMID: 11241047 BACKGROUND

• Hauser WA. The prevalence and incidence of convulsive disorders in children. Epilepsia. 1994;35 Suppl 2:S1-6. doi: 10.1111/j.1528-1157.1994.tb05932.x.

  PMID: 8275976 BACKGROUND

• Sperling MA, Menon RK. Differential diagnosis and management of neonatal hypoglycemia. Pediatr Clin North Am. 2004 Jun;51(3):703-23, x. doi: 10.1016/j.pcl.2004.01.014.

  PMID: 15157593 BACKGROUND

• Vilke GM, Castillo EM, Ray LU, Murrin PA, Chan TC. Evaluation of pediatric glucose monitoring and hypoglycemic therapy in the field. Pediatr Emerg Care. 2005 Jan;21(1):1-5. doi: 10.1097/01.pec.0000150980.94571.10.

  PMID: 15643315 BACKGROUND

• Valencia I, Sklar E, Blanco F, Lipsky C, Pradell L, Joffe M, Legido A. The role of routine serum laboratory tests in children presenting to the emergency department with unprovoked seizures. Clin Pediatr (Phila). 2003 Jul-Aug;42(6):511-7. doi: 10.1177/000992280304200605.

  PMID: 12921452 BACKGROUND

• Hirtz D, Ashwal S, Berg A, Bettis D, Camfield C, Camfield P, Crumrine P, Elterman R, Schneider S, Shinnar S. Practice parameter: evaluating a first nonfebrile seizure in children: report of the quality standards subcommittee of the American Academy of Neurology, The Child Neurology Society, and The American Epilepsy Society. Neurology. 2000 Sep 12;55(5):616-23. doi: 10.1212/wnl.55.5.616.

  PMID: 10980722 BACKGROUND

• Raizen DM, Brooks-Kayal A, Steinkrauss L, Tennekoon GI, Stanley CA, Kelly A. Central nervous system hyperexcitability associated with glutamate dehydrogenase gain of function mutations. J Pediatr. 2005 Mar;146(3):388-94. doi: 10.1016/j.jpeds.2004.10.040.

  PMID: 15756227 BACKGROUND

• Hauser WA. Seizure disorders: the changes with age. Epilepsia. 1992;33 Suppl 4:S6-14. doi: 10.1111/j.1528-1157.1992.tb06222.x.

  PMID: 1425495 BACKGROUND

• Melegh B, Pap M, Morava E, Molnar D, Dani M, Kurucz J. Carnitine-dependent changes of metabolic fuel consumption during long-term treatment with valproic acid. J Pediatr. 1994 Aug;125(2):317-21. doi: 10.1016/s0022-3476(94)70218-7.

  PMID: 8040784 BACKGROUND

• Nishida N, Sugimoto T, Araki A, Woo M, Sakane Y, Kobayashi Y. Carnitine metabolism in valproate-treated rats: the effect of L-carnitine supplementation. Pediatr Res. 1987 Nov;22(5):500-3. doi: 10.1203/00006450-198711000-00003.

  PMID: 3120144 BACKGROUND

• al-Hosani H, Salah M, Saade D, Osman H, al-Zahid J. United Arab Emirates National Newborn Screening Programme: an evaluation 1998-2000. East Mediterr Health J. 2003 May;9(3):324-32.

  PMID: 15751925 BACKGROUND

• Schweitzer-Krantz S. Early diagnosis of inherited metabolic disorders towards improving outcome: the controversial issue of galactosaemia. Eur J Pediatr. 2003 Dec;162 Suppl 1:S50-3. doi: 10.1007/s00431-003-1352-2. Epub 2003 Nov 12.

  PMID: 14614623 BACKGROUND

MeSH Terms

Conditions

Seizures; Hypoglycemia; Hyperammonemia; Hyperinsulinemic hypoglycemia, familial, 6

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Pathologic Processes

Study Officials

• Chetanbabu M Patel, MD

  Children's Mercy Hospital Kansas City

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 18, 2006
• First Posted: January 20, 2006
• Study Start: February 1, 2006
• Primary Completion: February 1, 2007
• Study Completion: February 1, 2007
• Last Updated: January 6, 2021

Record last verified: 2021-01

Locations

US (1)