NCT00279682

Brief Summary

The purpose of this study was to determine the effect of a primary care intervention on reducing suicidal ideation and depression in older patients.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,200

participants targeted

Target at P75+ for phase_4 depression

Timeline
Completed

Started May 1999

Typical duration for phase_4 depression

Geographic Reach
1 country

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 1999

Completed
4.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2003

Completed
2.5 years until next milestone

First Submitted

Initial submission to the registry

January 17, 2006

Completed
2 days until next milestone

First Posted

Study publicly available on registry

January 19, 2006

Completed
Last Updated

January 19, 2006

Status Verified

January 1, 2006

First QC Date

January 17, 2006

Last Update Submit

January 17, 2006

Conditions

DepressionSuicide, Attempted

Keywords

depressionsuicidegeriatricelderlyprimary care

Outcome Measures

Primary Outcomes (2)

  • Hamilton Depression Rating Scale

  • Scale for Suicide Ideation

Secondary Outcomes (2)

  • All cause and cause-specific mortality

  • disability (Sf12; instrumental activities of daily living)

Interventions

treatment guidelines and depression care managementBEHAVIORAL

Eligibility Criteria

Age60 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • upcoming appointment with primary care clinician

You may not qualify if:

  • inability to give consent
  • minimental status examination \<18
  • ability to communicate in English

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Weill Medical College of Cornell University

White Plains, New York, 10506, United States

Location

Universilty of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States

Location

Related Publications (8)

  • Bruce ML, Pearson JL. Designing an intervention to prevent suicide: PROSPECT (Prevention of Suicide in Primary Care Elderly: Collaborative Trial). Dialogues Clin Neurosci. 1999 Sep;1(2):100-12. doi: 10.31887/DCNS.1999.1.2/mbruce.

    PMID: 22033641BACKGROUND

  • Bruce ML, Ten Have TR, Reynolds CF 3rd, Katz II, Schulberg HC, Mulsant BH, Brown GK, McAvay GJ, Pearson JL, Alexopoulos GS. Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial. JAMA. 2004 Mar 3;291(9):1081-91. doi: 10.1001/jama.291.9.1081.

    PMID: 14996777RESULT

  • Alexopoulos GS, Katz IR, Bruce ML, Heo M, Ten Have T, Raue P, Bogner HR, Schulberg HC, Mulsant BH, Reynolds CF 3rd; PROSPECT Group. Remission in depressed geriatric primary care patients: a report from the PROSPECT study. Am J Psychiatry. 2005 Apr;162(4):718-24. doi: 10.1176/appi.ajp.162.4.718.

    PMID: 15800144RESULT

  • Gallo JJ, Bogner HR, Morales KH, Post EP, Ten Have T, Bruce ML. Depression, cardiovascular disease, diabetes, and two-year mortality among older, primary-care patients. Am J Geriatr Psychiatry. 2005 Sep;13(9):748-55. doi: 10.1176/appi.ajgp.13.9.748.

    PMID: 16166403RESULT

  • Gallo JJ, Hwang S, Truong C, Reynolds CF, Spira AP. Role of persistent and worsening sleep disturbance in depression remission and suicidal ideation among older primary care patients: the PROSPECT study. Sleep. 2020 Oct 13;43(10):zsaa063. doi: 10.1093/sleep/zsaa063.

    PMID: 32239161DERIVED

  • Gilman SE, Fitzmaurice GM, Bruce ML, Ten Have T, Glymour MM, Carliner H, Alexopoulos GS, Mulsant BH, Reynolds CF 3rd, Cohen A. Economic inequalities in the effectiveness of a primary care intervention for depression and suicidal ideation. Epidemiology. 2013 Jan;24(1):14-22. doi: 10.1097/EDE.0b013e3182762403.

    PMID: 23232609DERIVED

  • Bao Y, Alexopoulos GS, Casalino LP, Ten Have TR, Donohue JM, Post EP, Schackman BR, Bruce ML. Collaborative depression care management and disparities in depression treatment and outcomes. Arch Gen Psychiatry. 2011 Jun;68(6):627-36. doi: 10.1001/archgenpsychiatry.2011.55.

    PMID: 21646579DERIVED

  • Alexopoulos GS, Reynolds CF 3rd, Bruce ML, Katz IR, Raue PJ, Mulsant BH, Oslin DW, Ten Have T; PROSPECT Group. Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study. Am J Psychiatry. 2009 Aug;166(8):882-90. doi: 10.1176/appi.ajp.2009.08121779. Epub 2009 Jun 15.

    PMID: 19528195DERIVED

MeSH Terms

Conditions

DepressionSuicide, AttemptedSuicide

Condition Hierarchy (Ancestors)

Behavioral SymptomsBehaviorSelf-Injurious Behavior

Study Officials

  • George S Alexopoulos, MD

    Weill Medical College of Cornell University

    PRINCIPAL INVESTIGATOR

  • Ira Katz, MD. Ph.D.

    University of Pennsylvania

    PRINCIPAL INVESTIGATOR

  • Charles F Reynolds, MD

    University of Pittsburgh

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

January 17, 2006

First Posted

January 19, 2006

Study Start

May 1, 1999

Study Completion

August 1, 2003

Last Updated

January 19, 2006

Record last verified: 2006-01

Locations

US(3)