The Effect of Laser Hair Removal on Permanent Hair Reduction

NCT00279643 | Completed Phase 1

• 1 other identifier: Derm 543
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to learn more about how hair removal with lasers achieves, what appears to be, permanent hair reduction. Laser hair removal has become one of the most popular and commonly performed procedures in cosmetic dermatology. However, relatively little is known about how the permanent reduction in the treated areas occurs. Recently, it has been discovered that certain cells in the hair follicle must be destroyed in order to achieve permanent hair reduction. A marker of these types of cells known as keratin 15 has been identified. By measuring the amount of keratin 15 before and after laser therapy, we hope to gain a better understanding of how lasers cause hair reduction on a biochemical level.

Conditions

Laser Hair Removal in Healthy Subjects

Keywords

Laser; immunohistochemical staining; Laser Hair Removal; follicular stem cells; keratin 15

Outcome Measures

Primary Outcomes (1)

• measurement of the effects of laser hair removal on the immunohistochemical staining properties of human hair follicles, including the putative stem cells of the bulge region.

Secondary Outcomes (1)

• Hair Removal

Interventions

Laser Hair Removal PROCEDURE

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18 years or older of either gender.
• At least moderately dense axillary (armpit) hair that is dark (not blonde or white) in color.
• Subjects must understand and sign the informed consent documents prior to participation.
• Subjects must be in generally good health.
• Subjects must be willing and able to comply with the requirements of the protocol
• You must live within a reasonable driving distance of Ann Arbor, Michigan, and/or be able to attend all of the scheduled appointments during the study.

You may not qualify if:

• Oral retinoid use within one year of study entry.
• History of prior laser therapy or electrolysis of the axillae.
• Subjects who do not desire permanent reduction in axillary hair.
• Non-compliant subjects.
• Pregnant or nursing subjects.
• Subjects with a significant medical history or concurrent illness/condition that the investigator(s) feel is not safe for study participation.
• Active infection of the site to be treated or a history of herpes simplex or zoster infection at the site to be treated.
• History of keloid scar formation.
• Known history of allergy or sensitivity to lidocaine.
• History of waxing, plucking, or bleaching of the hair for 6 weeks prior to the treatment.

Sponsors & Collaborators

• University of Michigan: lead

Study Sites (1)

University of Michigan Department of Dermatology

Ann Arbor, Michigan, 48109, United States

Location

Study Officials

• John J Voorhees, MD

  University of Michigan

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Dermatology, Medical School

Study Record Dates

• First Submitted: January 17, 2006
• First Posted: January 19, 2006
• Study Start: January 1, 2005
• Study Completion: June 1, 2006
• Last Updated: April 30, 2015

Record last verified: 2015-04

Locations

US (1)