Stress, Environment, and Genetics in Urban Children With Asthma

NCT00269256 | Completed

• 2 other identifiers: 1322R01HL080674
• Study Type: observational
• Target: 959
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the multiple mechanisms through which stress, physical environment, and genetic predisposition contribute to asthma in urban children.

Conditions

Asthma; Lung Diseases

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Pregnant women and their children followed over first 5 years.

You may qualify if:

• Mothers aged 18 years or more at time of enrollment and speak English or Spanish.

Sponsors & Collaborators

• Brigham and Women's Hospital: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

Brigham & Women's Hospital

Boston, Massachusetts, 02115, United States

Location

Related Publications (6)

• Wright RJ, Fisher K, Chiu YH, Wright RO, Fein R, Cohen S, Coull BA. Disrupted prenatal maternal cortisol, maternal obesity, and childhood wheeze. Insights into prenatal programming. Am J Respir Crit Care Med. 2013 Jun 1;187(11):1186-93. doi: 10.1164/rccm.201208-1530OC.

  PMID: 23590260 BACKGROUND

• Chiu YH, Coull BA, Cohen S, Wooley A, Wright RJ. Prenatal and postnatal maternal stress and wheeze in urban children: effect of maternal sensitization. Am J Respir Crit Care Med. 2012 Jul 15;186(2):147-54. doi: 10.1164/rccm.201201-0162OC. Epub 2012 May 10.

  PMID: 22582161 BACKGROUND

• Peters JL, Cohen S, Staudenmayer J, Hosen J, Platts-Mills TA, Wright RJ. Prenatal negative life events increases cord blood IgE: interactions with dust mite allergen and maternal atopy. Allergy. 2012 Apr;67(4):545-51. doi: 10.1111/j.1398-9995.2012.02791.x. Epub 2012 Feb 6.

  PMID: 22309645 BACKGROUND

• Tse AC, Rich-Edwards JW, Koenen K, Wright RJ. Cumulative stress and maternal prenatal corticotropin-releasing hormone in an urban U.S. cohort. Psychoneuroendocrinology. 2012 Jul;37(7):970-9. doi: 10.1016/j.psyneuen.2011.11.004. Epub 2011 Dec 9.

  PMID: 22154479 BACKGROUND

• Sternthal MJ, Coull BA, Chiu YH, Cohen S, Wright RJ. Associations among maternal childhood socioeconomic status, cord blood IgE levels, and repeated wheeze in urban children. J Allergy Clin Immunol. 2011 Aug;128(2):337-45.e1. doi: 10.1016/j.jaci.2011.05.008. Epub 2011 Jun 25.

  PMID: 21704362 BACKGROUND

• Chiu YH, Coull BA, Sternthal MJ, Kloog I, Schwartz J, Cohen S, Wright RJ. Effects of prenatal community violence and ambient air pollution on childhood wheeze in an urban population. J Allergy Clin Immunol. 2014 Mar;133(3):713-22.e4. doi: 10.1016/j.jaci.2013.09.023. Epub 2013 Nov 4.

  PMID: 24200349 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

Maternal DNA Child DNA

MeSH Terms

Conditions

Asthma; Lung Diseases

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Rosalind Wright

  Brigham and Women's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: December 21, 2005
• First Posted: December 23, 2005
• Study Start: September 1, 2005
• Primary Completion: March 1, 2010
• Study Completion: March 1, 2010
• Last Updated: February 3, 2016

Record last verified: 2016-02

Locations

US (1)