Histoblood Group Antigens as a Risk Factor of Asthma

NCT00201266 | Completed

• 2 other identifiers: 283R01HL080414
• Study Type: observational
• Target: 126
• Locations: 1 country
• Sites: 1

Brief Summary

This study will evaluate the link between blood group antigens and asthma exacerbations.

Conditions

Asthma; Lung Diseases

Outcome Measures

Primary Outcomes (1)

• Asthma exacerbations requiring prednisone

  Prior 2 years

Secondary Outcomes (1)

• Lung fuction

  Current

Study Arms (2)

Exacerbation resistant asthma

Control group

Procedure: Screening

Exacerbation prone asthma

Cases

Procedure: Screening

Interventions

Screening PROCEDURE

Characterization tests including blood group typing, measures of lung function, measures of allergy, and collection of DNA.

Exacerbation prone asthma; Exacerbation resistant asthma

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Asthmatics of two types: 1. Exacerbation resistant asthma (no requirement for prednisone for asthma since age 12). 2. Exacerbation prone asthma (requirement for prednisone for asthma in the past 2 years).

You may qualify if:

• Diagnosis of asthma, as confirmed by methacholine responsiveness less than 8 mg/mL
• History of asthma exacerbation in the 2 years prior to study entry requiring treatment with oral corticosteroids

You may not qualify if:

• Cigarette smoking in the 10 years prior to study entry or total pack per year history greater than 10
• History of asthma exacerbations requiring treatment with oral corticosteroids since age 12 (control group)

Sponsors & Collaborators

• University of California, San Francisco: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

University of California, San Francisco

San Francisco, California, 94143, United States

Location

Related Publications (1)

• Innes AL, McGrath KW, Dougherty RH, McCulloch CE, Woodruff PG, Seibold MA, Okamoto KS, Ingmundson KJ, Solon MC, Carrington SD, Fahy JV. The H antigen at epithelial surfaces is associated with susceptibility to asthma exacerbation. Am J Respir Crit Care Med. 2011 Jan 15;183(2):189-94. doi: 10.1164/rccm.201003-0488OC. Epub 2010 Aug 23.

  PMID: 20732988 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

DNA, plasma, saliva, induced sputum.

MeSH Terms

Conditions

Asthma; Lung Diseases

Interventions

Mass Screening

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques and Procedures; Diagnosis; Health Surveys; Surveys and Questionnaires; Data Collection; Epidemiologic Methods; Investigative Techniques; Diagnostic Services; Preventive Health Services; Health Services; Health Care Facilities Workforce and Services; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Public Health Practice

Study Officials

• John V. Fahy

  University of California, San Francisco

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 16, 2005
• First Posted: September 20, 2005
• Study Start: July 1, 2005
• Primary Completion: August 1, 2011
• Study Completion: August 1, 2013
• Last Updated: March 9, 2026

Record last verified: 2026-03

Locations

US (1)