NCT00264303

Brief Summary

A study to compare the clinical efficacy and safety of Levocetirizine vs. Desloratadine in patients suffering from Chronic Idiopathic Urticaria (CIU) measured by the mean pruritus severity score over the first week of treatment

Trial Health

93
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
886

participants targeted

Target at P75+ for phase_4

Timeline
Completed

Started Dec 2005

Shorter than P25 for phase_4

Geographic Reach
9 countries

80 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2005

Completed
7 days until next milestone

First Submitted

Initial submission to the registry

December 8, 2005

Completed
4 days until next milestone

First Posted

Study publicly available on registry

December 12, 2005

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2007

Completed
2.5 years until next milestone

Results Posted

Study results publicly available

July 9, 2009

Completed
Last Updated

August 31, 2011

Status Verified

June 1, 2011

Enrollment Period

1.1 years

First QC Date

December 8, 2005

Results QC Date

May 18, 2009

Last Update Submit

August 30, 2011

Conditions

Keywords

Chronic Idiopathic UrticariaCUTE Levocetirizine Xyzal®

Outcome Measures

Primary Outcomes (1)

  • Mean Pruritus Severity Score Over the First Week of Treatment

    Pruritus severity is evaluated on an ordinal 4-point scale from 0 to 3 (0=none, 1=mild, 2=moderate). Mean pruritus severity score is averaged over the first week of treatment.

    over the first week of treatment

Secondary Outcomes (5)

  • Mean Chronic Idiopathic Urticaria (CIU) Composite Score Over the First Week of Treatment

    over the first week of treatment

  • Mean Chronic Idiopathic Urticaria (CIU) Composite Score Over the Four Weeks of Treatment

    over the four weeks of treatment

  • Mean Pruritus Severity Score Over the Four Weeks of Treatment

    over the four weeks of treatment

  • Mean Score for Pruritus Duration Over the First Week of Treatment

    over the first week of treatment

  • Mean Score for Pruritus Duration Over the Four Weeks of Treatment

    over the four weeks of treatment

Study Arms (2)

Levocetirizine

EXPERIMENTAL

Levocetirizine, once daily, 4 week duration

Drug: Levocetirizine

Desloratadine

ACTIVE COMPARATOR

Desloratadine, once daily, 4 week duration

Drug: Desloratadine

Interventions

5mg oral capsules, once daily, 4 week duration

Levocetirizine

5mg oral capsules, once daily, 4 week duration

Desloratadine

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • \- At visit 1: Clinical history of Chronic Idiopathic Urticaria for a period of at least 6 weeks during the last 3 months without an identifiable cause
  • \- At visit 2 (after a baseline period of at least 3 days): patient with adequate signs of CIU, both in terms of symptoms and severity.

You may not qualify if:

  • \- Any condition that would interfere with the evaluation of the therapeutic response.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (80)

Unknown Facility

Bruges, Belgium

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Brussels, Belgium

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Liège, Belgium

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Merksem, Belgium

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Sint-Niklaas, Belgium

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Woluwe-St-Lamb, Belgium

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Bernay, France

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Besançon, France

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Hyères, France

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Les Milles, France

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Marseille, France

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Montpellier, France

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Nancy, France

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Nantes, France

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Nice, France

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Nîmes, France

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Paris, France

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Poitiers, France

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Quimper, France

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Saint-Mandé, France

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Troyes, France

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Valence, France

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Villejuif, France

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Augsburg, Germany

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Berlin, Germany

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Cologne, Germany

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Dresden, Germany

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Düsseldorf, Germany

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Erlangen, Germany

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Göttingen, Germany

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Hamburg, Germany

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Hanover, Germany

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Leipzig, Germany

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Mahlow, Germany

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Mainz, Germany

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München, Germany

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Viersen, Germany

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Caserta, Italy

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Catania, Italy

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Cesena, Italy

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Genova, Italy

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Modena, Italy

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Palermo, Italy

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Pavia, Italy

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Roma, Italy

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Siena, Italy

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Udine, Italy

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Verona, Italy

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Johor Bharu, Malaysia

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Kelantan, Malaysia

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Kuala Lumpur, Malaysia

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Negeri Sembilan, Malaysia

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Perak, Malaysia

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Pulau Pinang, Malaysia

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Sarawak, Malaysia

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Brasov, Romania

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Bucharest, Romania

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Dolj, Romania

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Sibiu, Romania

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Cape Town, South Africa

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Durban, South Africa

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Lenasia, South Africa

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A Coruña, Spain

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Albacete, Spain

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Barcelona, Spain

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Granada, Spain

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Madrid, Spain

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Málaga, Spain

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Murcia (El Palmar), Spain

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Oviedo, Spain

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Santiago de Compostela, Spain

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Seville, Spain

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Valencia, Spain

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Amersham, United Kingdom

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Cardiff, United Kingdom

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Irvine, United Kingdom

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Leicester, United Kingdom

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London, United Kingdom

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Nuneaton, United Kingdom

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Salford, United Kingdom

Location

Related Links

MeSH Terms

Conditions

Chronic Urticaria

Interventions

levocetirizinedesloratadine

Condition Hierarchy (Ancestors)

UrticariaSkin Diseases, VascularSkin DiseasesSkin and Connective Tissue DiseasesHypersensitivity, ImmediateHypersensitivityImmune System DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Results Point of Contact

Title
UCB Clinical Trial Call Center
Organization
UCB Pharma

Study Officials

  • UCB Clinical Trial Call Center

    +1 877 822 9493 (UCB)

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 8, 2005

First Posted

December 12, 2005

Study Start

December 1, 2005

Primary Completion

January 1, 2007

Study Completion

January 1, 2007

Last Updated

August 31, 2011

Results First Posted

July 9, 2009

Record last verified: 2011-06

Locations