NCT00260468

Brief Summary

The objective of this project is to examine the state of the brain in people over 50 years old suffering from late-onset depression by means of an extensive clinical assessment programme, including magnetic resonance imaging (MRI), neuropsychological testing, neurological examination, eye examination as well as blood and saliva samples. The results are to be compared with results from a control group matched for gender and age.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
44

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Nov 2005

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2005

Completed
29 days until next milestone

First Submitted

Initial submission to the registry

November 30, 2005

Completed
1 day until next milestone

First Posted

Study publicly available on registry

December 1, 2005

Completed
3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2008

Completed
Last Updated

October 22, 2009

Status Verified

October 1, 2009

First QC Date

November 30, 2005

Last Update Submit

October 21, 2009

Conditions

Major Depression

Keywords

Major depressionMagnetic resonance imagingWhite matter lesionsPerfusionDiffusionMagnetization transferVascular risk factors

Interventions

Clinical examination programOTHER

Psychiatric/clinical interview MRI scan Blood samples Saliva samples Eye examination

Eligibility Criteria

Age50 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

1. Subjects with first-episode late-onset major depression from psychiatric hospital or clinic 2. Healthy controls

You may qualify if:

  • first time major depression
  • age over 50 years
  • Caucasian
  • admitted at a psychiatric hospital or treated at a local psychiatric clinic in Aarhus Amt

You may not qualify if:

  • major brain damage (e.g. stroke, epilepsy, trauma)
  • major alcohol or drug abuse

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Centre for Psychiatric Research, Aarhus University Hospital

Risskov, DK-8240, Denmark

Location

Related Links

Biospecimen

Retention: SAMPLES WITH DNA

Apolipoprotein

MeSH Terms

Conditions

Depressive Disorder, Major

Condition Hierarchy (Ancestors)

Depressive DisorderMood DisordersMental Disorders

Study Officials

  • Raben Rosenberg, Professor, MD, DrMedSc

    Aarhus University Hospital

    STUDY DIRECTOR

  • Videbech Poul, Professor, MD, DrMedSc

    Aarhus University Hospital

    PRINCIPAL INVESTIGATOR

  • Leif Østergaard, Professor, MD, DrMedSc, PhD

    Center for Functionally Integrative Neuroscience (CFIN), Aarhus University Hospital, Denmark

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER

Study Record Dates

First Submitted

November 30, 2005

First Posted

December 1, 2005

Study Start

November 1, 2005

Study Completion

December 1, 2008

Last Updated

October 22, 2009

Record last verified: 2009-10

Locations

DK(1)