NCT00255931

Brief Summary

The purpose of this study is to determine the effect of biofeedback-relaxation combined with cognitive behavioral therapy on clinical, physical and psychological outcomes in patients with heart failure.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
380

participants targeted

Target at P75+ for phase_2 heart-failure

Timeline
Completed

Started Jul 2004

Longer than P75 for phase_2 heart-failure

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2004

Completed
1.4 years until next milestone

First Submitted

Initial submission to the registry

November 16, 2005

Completed
5 days until next milestone

First Posted

Study publicly available on registry

November 21, 2005

Completed
4.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2010

Completed
Last Updated

June 5, 2012

Status Verified

June 1, 2012

Enrollment Period

5.8 years

First QC Date

November 16, 2005

Last Update Submit

June 2, 2012

Conditions

Keywords

Heart FailureBiofeedback-RelaxationCognitive Behavioral Therapy

Outcome Measures

Primary Outcomes (1)

  • Examination of the impact of biofeedback-relaxation training on HF patient outcomes.

    Baseline, 3-, and 12-Months

Secondary Outcomes (6)

  • Perceived Control

    Baseline, 3-, and 12-Months

  • Anxiety

    Baseline, 3-, and 12-Months

  • Depression

    Baseline, 3-, and 12-Months

  • Skin Temperature

    Baseline, 3-, and 12-Months

  • Heart Rate Variability

    Baseline, 3-, and 12-Months

  • +1 more secondary outcomes

Study Arms (3)

1

EXPERIMENTAL
Behavioral: Cognitive Behavioral Therapy

2

PLACEBO COMPARATOR
Behavioral: Attention Placebo

3

NO INTERVENTION

Usual Care

Interventions

Cognitive Behavioral Therapy and Relaxation/biofeedback

1

Untrained relaxation

2

Eligibility Criteria

Age21 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • confirmed diagnosis of chronic advanced HF. Other sample selection criteria include: 1) on stable doses of HF medication for at least one month; and 2) not referred for heart transplantation.

You may not qualify if:

  • Patients will be excluded if they have: 1) valvular heart disease (as a primary cause of their HF; can have it if the primary cause is ischemic, hypertensive or idiopathic), peripartum heart failure, myocarditis; 2) history of cerebral vascular accident (CVA) within previous 3 months or major stroke sequelae; 3) history of major extremity vascular problems; 4) recent (within 3 months) myocardial infarction (MI); 5) coexisting terminal illness; 6) systolic blood pressure less than 80 mmHg; or 7) previous experience with biofeedback, relaxation .

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Kentucky

Lexington, Kentucky, 40535, United States

Location

MeSH Terms

Conditions

Heart Failure

Interventions

Cognitive Behavioral Therapy

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

Behavior TherapyPsychotherapyBehavioral Disciplines and Activities

Study Officials

  • Debra Moser, DNSc, RN

    University of Kentucky

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

November 16, 2005

First Posted

November 21, 2005

Study Start

July 1, 2004

Primary Completion

May 1, 2010

Study Completion

May 1, 2010

Last Updated

June 5, 2012

Record last verified: 2012-06

Locations