NCT00250315

Brief Summary

Patients with cirrhosis have a altered cardiac response to stress. This study evaluate the cardiac response by MRI during dobutamine stress. Hypothesis: impared increase in cardiac output, cardiac index, ejection fraction.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Nov 2005

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2005

Completed
3 days until next milestone

First Submitted

Initial submission to the registry

November 4, 2005

Completed
4 days until next milestone

First Posted

Study publicly available on registry

November 8, 2005

Completed
1.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2007

Completed
Last Updated

November 1, 2007

Status Verified

October 1, 2007

First QC Date

November 4, 2005

Last Update Submit

October 31, 2007

Conditions

CirrhosisCirrhotic Cardiomyopathy

Interventions

DobutamineDRUG

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Non alkoholic cirrhosis

You may not qualify if:

  • Coma hepaticum
  • Primary cardiac diseases

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hvidovre University Hospital

Copenhagen, Hvidovre, 2650, Denmark

Location

Related Publications (1)

  • Dahl EK, Moller S, Kjaer A, Petersen CL, Bendtsen F, Krag A. Diastolic and autonomic dysfunction in early cirrhosis: a dobutamine stress study. Scand J Gastroenterol. 2014 Mar;49(3):362-72. doi: 10.3109/00365521.2013.867359. Epub 2013 Dec 16.

    PMID: 24329122DERIVED

MeSH Terms

Conditions

Fibrosis

Interventions

Dobutamine

Condition Hierarchy (Ancestors)

Pathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

CatecholaminesAminesOrganic ChemicalsPhenethylaminesEthylaminesCatecholsPhenolsBenzene DerivativesHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbons

Study Officials

  • Søren Møller, DrMsci, MD

    Hvidovre University Hospital

    STUDY DIRECTOR

Study Design

Study Type
observational
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

November 4, 2005

First Posted

November 8, 2005

Study Start

November 1, 2005

Study Completion

October 1, 2007

Last Updated

November 1, 2007

Record last verified: 2007-10

Locations

DK(1)