Immune Responses to BCG Vaccination in Malawi and the UK
1 other identifier
interventional
N/A
2 countries
2
Brief Summary
BCG vaccination has been found to provide greater protection against TB in the UK than in Malawi. This study compares immune responses in BCG-vaccinated and unvaccinated teenagers and young adults in Malawi and in the UK.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 17, 2005
CompletedFirst Posted
Study publicly available on registry
October 19, 2005
CompletedDecember 15, 2005
December 1, 2002
October 17, 2005
December 14, 2005
Conditions
Outcome Measures
Primary Outcomes (2)
Delayed-type hypersensitivity
cytokine responses (eg IFNg) to mycobacterial antigens
Secondary Outcomes (1)
scar size
Interventions
Eligibility Criteria
You may qualify if:
- BCG unvaccinated
- HIV negative
- Not pregnant
- Informed Consent
You may not qualify if:
- HIV positive
- Pregnant
- Seriously ill
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Karonga Prevention Study
Chilumba, Karonga District, PO Box 36, Malawi
Redbridge and Waltham Forest Primary Care Trust
Ilford, Essex, IG1 2QX, United Kingdom
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Paul EM Fine, VMD, PhD
London School of Hygiene and Tropical Medicine