Study Stopped
See detailed description for reason.
JUPITER - Crestor 20mg Versus Placebo in Prevention of Cardiovascular (CV) Events
A Randomized, Double-Blind, Placebo Controlled, Multicenter, Phase 3 Study of Rosuvastatin (CRESTOR®) 20 mg in the Prevention of Cardiovascular Events Among Subjects With Low Levels of Low Density Lipoprotein(LDL) Cholesterol & Elevated Levels of C-Reactive Protein
3 other identifiers
interventional
17,802
26 countries
848
Brief Summary
The purpose of this study is to determine the safety and effectiveness of long-term therapy with rosuvastatin compared with a placebo, and to evaluate whether treatment with rosuvastatin might be effective in reducing the risk of major cardiovascular events.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Feb 2003
Longer than P75 for phase_3
848 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2003
CompletedFirst Submitted
Initial submission to the registry
October 13, 2005
CompletedFirst Posted
Study publicly available on registry
October 17, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2008
CompletedResults Posted
Study results publicly available
March 24, 2014
CompletedMarch 24, 2014
February 1, 2014
5.6 years
October 13, 2005
August 20, 2009
February 6, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Time to Major Cardiac Event (Cardiovascular Death, Stroke, Myocardial Infarction, Hospitalization Due to Unstable Angina or Arterial Revascularization)
Days from randomization to the first of CV death, stroke, MI, hospitalization for unstable angina or arterial revascularization. If no event, censoring occurs at earliest of termination date or efficacy cut-off date of 30 Mar 2008. Events were adjudicated by an endpoint committee. Kaplan-Meier estimate of the mean
up to 5 years
Secondary Outcomes (5)
Time to Death Due to Any Cause
up to 5 years
Time to Non-cardiovascular Death
up to 5 years
Time to Development of Diabetes Mellitus
up to 5 years
Time to Venous Thromboembolic Event
up to 5 years
Time to Bone Fracture
Up to 5 years
Study Arms (2)
Rosuvastatin
EXPERIMENTALRosuvastatin 20 mg once daily
Placebo
PLACEBO COMPARATORPlacebo once daily
Interventions
Eligibility Criteria
You may qualify if:
- Men 50 years or older, women 60 years or older
- Low to normal levels of low density lipoprotein (LDL) cholesterol (\< 130mg/dL)
- Elevated levels of C-Reactive Protein (CRP) \> 2.0 mg/L
You may not qualify if:
- History of cardiovascular or cerebrovascular events
- Active liver disease
- Diabetes mellitus
- Uncontrolled hypertension or hypothyroidism
- History of certain malignancies
- Chronic inflammatory conditions
- History of alcohol or drug abuse
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AstraZenecalead
Study Sites (856)
Research Site
Birmingham, Alabama, United States
Research Site
Calera, Alabama, United States
Research Site
Columbiana, Alabama, United States
Research Site
Decatur, Alabama, United States
Research Site
Graysville, Alabama, United States
Research Site
Haleyville, Alabama, United States
Research Site
Hartselle, Alabama, United States
Research Site
Huntsville, Alabama, United States
Research Site
Mobile, Alabama, United States
Research Site
Montgomery, Alabama, United States
Research Site
Muscle Shoals, Alabama, United States
Research Site
South Birmingham, Alabama, United States
Research Site
Tuscumbia, Alabama, United States
Research Site
Mesa, Arizona, United States
Research Site
Phoenix, Arizona, United States
Research Site
Scottsdale, Arizona, United States
Research Site
Tucson, Arizona, United States
Research Site
Fayetteville, Arkansas, United States
Research Site
Hot Springs, Arkansas, United States
Research Site
Little Rock, Arkansas, United States
Research Site
Pine Bluff, Arkansas, United States
Research Site
Alhambra, California, United States
Research Site
Azusa, California, United States
Research Site
Berkeley, California, United States
Research Site
Beverly Hills, California, United States
Research Site
Burlingame, California, United States
Research Site
Carmichael, California, United States
Research Site
Concord, California, United States
Research Site
Culver City, California, United States
Research Site
Daly City, California, United States
Research Site
Folsom, California, United States
Research Site
Foothill Ranch, California, United States
Research Site
Fountain Valley, California, United States
Research Site
Fresno, California, United States
Research Site
Garden Grove, California, United States
Research Site
Inglewood, California, United States
Research Site
Irvine, California, United States
Research Site
La Jolla, California, United States
Research Site
La Mesa, California, United States
Research Site
Languna Niguel, California, United States
Research Site
Long Beach, California, United States
Research Site
Los Angeles, California, United States
Research Site
Los Gatos, California, United States
Research Site
Mission Hills, California, United States
Research Site
Mission Viejo, California, United States
Research Site
Modesto, California, United States
Research Site
Newport Beach, California, United States
Research Site
Norwalk, California, United States
Research Site
Orange, California, United States
Research Site
Orangevale, California, United States
Research Site
Palm Desert, California, United States
Research Site
Pasadena, California, United States
Research Site
Pismo Beach, California, United States
Research Site
Pomona, California, United States
Research Site
Riverside, California, United States
Research Site
Roseville, California, United States
Research Site
Sacramento, California, United States
Research Site
San Diego, California, United States
Research Site
San Jose, California, United States
Research Site
San Ramon, California, United States
Research Site
Santa Ana, California, United States
Research Site
Santa Monica, California, United States
Research Site
Thousand Oaks, California, United States
Research Site
Torrance, California, United States
Research Site
Upland, California, United States
Research Site
Ventura, California, United States
Research Site
Vista, California, United States
Research Site
Walnut Creek, California, United States
Research Site
Westlake Village, California, United States
Research Site
Aurora, Colorado, United States
Research Site
Colorado Springs, Colorado, United States
Research Site
Denver, Colorado, United States
Research Site
Fort Collins, Colorado, United States
Research Site
Golden, Colorado, United States
Research Site
Highlands Ranch, Colorado, United States
Research Site
Littleton, Colorado, United States
Research Site
Loveland, Colorado, United States
Research Site
Avon, Connecticut, United States
Research Site
Bristol, Connecticut, United States
Research Site
Hartford, Connecticut, United States
Research Site
Stamford, Connecticut, United States
Research Site
Trumbull, Connecticut, United States
Research Site
West Hartford, Connecticut, United States
Research Site
Newark, Delaware, United States
Research Site
Wlimington, Delaware, United States
Research Site
Washington D.C., District of Columbia, United States
Research Site
Apopka, Florida, United States
Research Site
Beverly Hills, Florida, United States
Research Site
Cape Coral, Florida, United States
Research Site
Clearwater, Florida, United States
Research Site
Cooper City, Florida, United States
Research Site
Crystal River, Florida, United States
Research Site
Davie, Florida, United States
Research Site
Deerfield Beach, Florida, United States
Research Site
Delray Beach, Florida, United States
Research Site
Fort Lauderdale, Florida, United States
Research Site
Gainesville, Florida, United States
Research Site
Jacksonville, Florida, United States
Research Site
Lakeland, Florida, United States
Research Site
Largo, Florida, United States
Research Site
Margate, Florida, United States
Research Site
Miami, Florida, United States
Research Site
North Miami Beach, Florida, United States
Research Site
Orlando, Florida, United States
Research Site
Ormond Beach, Florida, United States
Research Site
Palm Harbor, Florida, United States
Research Site
Pensacola, Florida, United States
Research Site
Port Charlotte, Florida, United States
Research Site
Port Orange, Florida, United States
Research Site
Sarasota, Florida, United States
Research Site
Sebastian, Florida, United States
Research Site
Tamarac, Florida, United States
Research Site
Tampa, Florida, United States
Research Site
Vero Beach, Florida, United States
Research Site
West Palm Beach, Florida, United States
Research Site
Atlanta, Georgia, United States
Research Site
Augusta, Georgia, United States
Research Site
Blue Ridge, Georgia, United States
Research Site
Brunswick, Georgia, United States
Research Site
Columbus, Georgia, United States
Research Site
Conyers, Georgia, United States
Research Site
Decatur, Georgia, United States
Research Site
Fayetteville, Georgia, United States
Research Site
Suwanee, Georgia, United States
Research Site
Woodstock, Georgia, United States
Research Site
Idaho Falls, Idaho, United States
Research Site
Meridian, Idaho, United States
Research Site
Aurora, Illinois, United States
Research Site
Champaign, Illinois, United States
Research Site
Chicago, Illinois, United States
Research Site
Gurnee, Illinois, United States
Research Site
Lake Road, Illinois, United States
Research Site
Melrose Park, Illinois, United States
Research Site
Morton, Illinois, United States
Research Site
O'Fallon, Illinois, United States
Research Site
Orland Park, Illinois, United States
Research Site
Springfield, Illinois, United States
Research Site
Sterling, Illinois, United States
Research Site
Vernon Hills, Illinois, United States
Research Site
Avon, Indiana, United States
Research Site
Evansville, Indiana, United States
Research Site
Granger, Indiana, United States
Research Site
Indianapolis, Indiana, United States
Research Site
Jeffersonville, Indiana, United States
Research Site
Munster, Indiana, United States
Research Site
Newburgh, Indiana, United States
Research Site
Valparaiso, Indiana, United States
Research Site
Des Moines, Iowa, United States
Research Site
Dubuque, Iowa, United States
Research Site
Iowa City, Iowa, United States
Research Site
West Des Moines, Iowa, United States
Research Site
Leavenworth, Kansas, United States
Research Site
Olathe, Kansas, United States
Research Site
Overland Park, Kansas, United States
Research Site
Shawnee Mission, Kansas, United States
Research Site
Topeka, Kansas, United States
Research Site
Wichita, Kansas, United States
Research Site
Evansville, Kentucky, United States
Research Site
Lexington, Kentucky, United States
Research Site
Louisville, Kentucky, United States
Research Site
Baton Rouge, Louisiana, United States
Research Site
Covington, Louisiana, United States
Research Site
Houma, Louisiana, United States
Research Site
Lake Charles, Louisiana, United States
Research Site
Marrero, Louisiana, United States
Research Site
New Orleans, Louisiana, United States
Research Site
Shreveport, Louisiana, United States
Research Site
Auburn, Maine, United States
Research Site
Bangor, Maine, United States
Research Site
Portland, Maine, United States
Research Site
Sanford, Maine, United States
Research Site
South Portland, Maine, United States
Research Site
Baltimore, Maryland, United States
Research Site
Charlotte Hall, Maryland, United States
Research Site
Glen Burnie, Maryland, United States
Research Site
Hagerstown, Maryland, United States
Research Site
Prince Frederick, Maryland, United States
Research Site
Rockville, Maryland, United States
Research Site
Towson, Maryland, United States
Research Site
Ayer, Massachusetts, United States
Research Site
Boston, Massachusetts, United States
Research Site
Burlington, Massachusetts, United States
Research Site
East Bridgewater, Massachusetts, United States
Research Site
Haverhill, Massachusetts, United States
Research Site
Natick, Massachusetts, United States
Research Site
Newton, Massachusetts, United States
Research Site
Springfield, Massachusetts, United States
Research Site
West Yarmouth, Massachusetts, United States
Research Site
Worcester, Massachusetts, United States
Research Site
Berkley, Michigan, United States
Research Site
Dearborn, Michigan, United States
Research Site
Grand Rapids, Michigan, United States
Research Site
Livonia, Michigan, United States
Research Site
Petoskey, Michigan, United States
Research Site
Portage, Michigan, United States
Research Site
Saint Joseph, Michigan, United States
Research Site
Troy, Michigan, United States
Research Site
Warren, Michigan, United States
Research Site
Chaska, Minnesota, United States
Research Site
Duluth, Minnesota, United States
Research Site
Minneapolis, Minnesota, United States
Research Site
Rochester, Minnesota, United States
Research Site
Saint Paul, Minnesota, United States
Research Site
Gulfport, Mississippi, United States
Research Site
Jackson, Mississippi, United States
Research Site
Olive Branch, Mississippi, United States
Research Site
Picayune, Mississippi, United States
Research Site
Port Gibson, Mississippi, United States
Research Site
Chesterfield, Missouri, United States
Research Site
Excelsior Springs, Missouri, United States
Research Site
Jefferson City, Missouri, United States
Research Site
Kansas City, Missouri, United States
Research Site
Manchester, Missouri, United States
Research Site
Mexico, Missouri, United States
Research Site
Rolla, Missouri, United States
Research Site
Saint Charles, Missouri, United States
Research Site
Shawnee Mission, Missouri, United States
Research Site
Springfield, Missouri, United States
Research Site
St Louis, Missouri, United States
Research Site
Washington, Missouri, United States
Research Site
Wentzville, Missouri, United States
Research Site
Anaconda, Montana, United States
Research Site
Butte, Montana, United States
Research Site
Kalispell, Montana, United States
Research Site
Missoula, Montana, United States
Research Site
Grand Island, Nebraska, United States
Research Site
Omaha, Nebraska, United States
Research Site
Henderson, Nevada, United States
Research Site
Las Vegas, Nevada, United States
Research Site
Pahrump, Nevada, United States
Research Site
Nashua, New Hampshire, United States
Research Site
Bloomfield, New Jersey, United States
Research Site
Brick, New Jersey, United States
Research Site
Cherry Hill, New Jersey, United States
Research Site
Elizabeth, New Jersey, United States
Research Site
Englewood Cliffs, New Jersey, United States
Research Site
Morristown, New Jersey, United States
Research Site
Newark, New Jersey, United States
Research Site
Northbrunswick, New Jersey, United States
Research Site
Passaic, New Jersey, United States
Research Site
Teaneck, New Jersey, United States
Research Site
Trenton, New Jersey, United States
Research Site
West Caldwell, New Jersey, United States
Research Site
Albuquerque, New Mexico, United States
Research Site
Los Alamos, New Mexico, United States
Research Site
Rio Rancho, New Mexico, United States
Research Site
Albany, New York, United States
Research Site
Binghamton, New York, United States
Research Site
Bowmansville, New York, United States
Research Site
Bronxville, New York, United States
Research Site
Brooklyn, New York, United States
Research Site
Buffalo, New York, United States
Research Site
Camillus, New York, United States
Research Site
East Islip, New York, United States
Research Site
East Syracuse, New York, United States
Research Site
Fayetteville, New York, United States
Research Site
Lake Success, New York, United States
Research Site
Mamaroneck, New York, United States
Research Site
Mount Vernon, New York, United States
Research Site
New Hartford, New York, United States
Research Site
New Hyde Park, New York, United States
Research Site
New York, New York, United States
Research Site
Niagara Falls, New York, United States
Research Site
Poughkeepsie, New York, United States
Research Site
Riverhead, New York, United States
Research Site
Rochester, New York, United States
Research Site
Syracuse, New York, United States
Research Site
The Bronx, New York, United States
Research Site
Tonawanda, New York, United States
Research Site
Williamsville, New York, United States
Research Site
Asheville, North Carolina, United States
Research Site
Burlington, North Carolina, United States
Research Site
Cary, North Carolina, United States
Research Site
Chapel Hill, North Carolina, United States
Research Site
Charlotte, North Carolina, United States
Research Site
Durham, North Carolina, United States
Research Site
Fayetteville, North Carolina, United States
Research Site
Lenoir, North Carolina, United States
Research Site
Lexington, North Carolina, United States
Research Site
Raleigh, North Carolina, United States
Research Site
Statesville, North Carolina, United States
Research Site
Winston-Salem, North Carolina, United States
Research Site
Fargo, North Dakota, United States
Research Site
Akron, Ohio, United States
Research Site
Athens, Ohio, United States
Research Site
Bellbrook, Ohio, United States
Research Site
Canal Fulton, Ohio, United States
Research Site
Centerville, Ohio, United States
Research Site
Chesterland, Ohio, United States
Research Site
Cincinnati, Ohio, United States
Research Site
Columbus, Ohio, United States
Research Site
Dayton, Ohio, United States
Research Site
Mansfield, Ohio, United States
Research Site
Massillon, Ohio, United States
Research Site
Maumee, Ohio, United States
Research Site
Wadsworth, Ohio, United States
Research Site
Warren, Ohio, United States
Research Site
Zanesville, Ohio, United States
Research Site
Guthrie, Oklahoma, United States
Research Site
Muskogee, Oklahoma, United States
Research Site
Oklahoma City, Oklahoma, United States
Research Site
Tulsa, Oklahoma, United States
Research Site
Yukon, Oklahoma, United States
Research Site
Corvallis, Oregon, United States
Research Site
Dallas, Oregon, United States
Research Site
Eugene, Oregon, United States
Research Site
Lake Oswego, Oregon, United States
Research Site
Medford, Oregon, United States
Research Site
Milwaukie, Oregon, United States
Research Site
Portland, Oregon, United States
Research Site
Springfield, Oregon, United States
Research Site
Altoona, Pennsylvania, United States
Research Site
Beaver, Pennsylvania, United States
Research Site
Bloomsburg, Pennsylvania, United States
Research Site
Broomall, Pennsylvania, United States
Research Site
Camp Hill, Pennsylvania, United States
Research Site
Connellsville, Pennsylvania, United States
Research Site
Downingtown, Pennsylvania, United States
Research Site
Erie, Pennsylvania, United States
Research Site
Feasterville, Pennsylvania, United States
Research Site
Fleetwood, Pennsylvania, United States
Research Site
Harleysville, Pennsylvania, United States
Research Site
Harrisburg, Pennsylvania, United States
Research Site
Jersey Shore, Pennsylvania, United States
Research Site
King of Prussia, Pennsylvania, United States
Research Site
Lansdale, Pennsylvania, United States
Research Site
Lansdowne, Pennsylvania, United States
Research Site
Lewisburg, Pennsylvania, United States
Research Site
Lewistown, Pennsylvania, United States
Research Site
Lock Haven, Pennsylvania, United States
Research Site
McMurray, Pennsylvania, United States
Research Site
Melrose Park, Pennsylvania, United States
Research Site
Norristown, Pennsylvania, United States
Research Site
Philadelphia, Pennsylvania, United States
Research Site
Pittsburgh, Pennsylvania, United States
Research Site
Plymouth Meeting, Pennsylvania, United States
Research Site
Reading, Pennsylvania, United States
Research Site
Scotland, Pennsylvania, United States
Research Site
Sellersville, Pennsylvania, United States
Research Site
Souderton, Pennsylvania, United States
Research Site
Springfield, Pennsylvania, United States
Research Site
State College, Pennsylvania, United States
Research Site
Stoneboro, Pennsylvania, United States
Research Site
Tipton, Pennsylvania, United States
Research Site
Uniontown, Pennsylvania, United States
Research Site
Upland, Pennsylvania, United States
Research Site
Wallingford, Pennsylvania, United States
Research Site
Warminster, Pennsylvania, United States
Research Site
West Grove, Pennsylvania, United States
Research Site
West Reading, Pennsylvania, United States
Research Site
Wilkes-Barre, Pennsylvania, United States
Research Site
York, Pennsylvania, United States
Research Site
Cranston, Rhode Island, United States
Research Site
Johnston, Rhode Island, United States
Research Site
Pawtucket, Rhode Island, United States
Research Site
Providence, Rhode Island, United States
Research Site
Charleston, South Carolina, United States
Research Site
Greenville, South Carolina, United States
Research Site
Greer, South Carolina, United States
Research Site
Hampton, South Carolina, United States
Research Site
Moncks Corner, South Carolina, United States
Research Site
Mt. Pleasant, South Carolina, United States
Research Site
Orangeburg, South Carolina, United States
Research Site
Simpsonville, South Carolina, United States
Research Site
Sioux Falls, South Dakota, United States
Research Site
Bristol, Tennessee, United States
Research Site
Chattanooga, Tennessee, United States
Research Site
Clarksville, Tennessee, United States
Research Site
Fayetteville, Tennessee, United States
Research Site
Germantown, Tennessee, United States
Research Site
Hendersonville, Tennessee, United States
Research Site
Jefferson City, Tennessee, United States
Research Site
Johnson City, Tennessee, United States
Research Site
Memphis, Tennessee, United States
Research Site
Morristown, Tennessee, United States
Research Site
Nashville, Tennessee, United States
Research Site
Arlington, Texas, United States
Research Site
Austin, Texas, United States
Research Site
Carrollton, Texas, United States
Research Site
Colleyville, Texas, United States
Research Site
Corpus Christi, Texas, United States
Research Site
Dallas, Texas, United States
Research Site
El Paso, Texas, United States
Research Site
Fort Worth, Texas, United States
Research Site
Friendswood, Texas, United States
Research Site
Grapevine, Texas, United States
Research Site
Houston, Texas, United States
Research Site
Irving, Texas, United States
Research Site
Lake Jackson, Texas, United States
Research Site
Lubbock, Texas, United States
Research Site
New Braunfels, Texas, United States
Research Site
North Richland Hills, Texas, United States
Research Site
Pharr, Texas, United States
Research Site
Plano, Texas, United States
Research Site
San Antonio, Texas, United States
Research Site
Seguin, Texas, United States
Research Site
Sugar Land, Texas, United States
Research Site
The Woodlands, Texas, United States
Research Site
Tyler, Texas, United States
Research Site
Bountiful, Utah, United States
Research Site
Nephi, Utah, United States
Research Site
Salt Lake City, Utah, United States
Research Site
Burlington, Vermont, United States
Research Site
Alexandria, Virginia, United States
Research Site
Arlington, Virginia, United States
Research Site
Burke, Virginia, United States
Research Site
Charlottesville, Virginia, United States
Research Site
Hampton, Virginia, United States
Research Site
Hayes, Virginia, United States
Research Site
Norfolk, Virginia, United States
Research Site
Quinton, Virginia, United States
Research Site
Richmond, Virginia, United States
Research Site
Springfield, Virginia, United States
Research Site
Stuart, Virginia, United States
Research Site
Suffolk, Virginia, United States
Research Site
Weber City, Virginia, United States
Research Site
Yorktown, Virginia, United States
Research Site
Burien, Washington, United States
Research Site
Everett, Washington, United States
Research Site
Gig Harbor, Washington, United States
Research Site
Olympia, Washington, United States
Research Site
Seattle, Washington, United States
Research Site
Spokane, Washington, United States
Research Site
Wenatchee, Washington, United States
Research Site
Charleston, West Virginia, United States
Research Site
Lewisburg, West Virginia, United States
Research Site
Beloit, Wisconsin, United States
Research Site
Green Bay, Wisconsin, United States
Research Site
Madison, Wisconsin, United States
Research Site
Menomonee Falls, Wisconsin, United States
Research Site
Milwaukee, Wisconsin, United States
Research Site
Capital Federal, Buenos Aires, Argentina
Research Site
Pilar, Buenos Aires, Argentina
Research Site
Quilmes, Buenos Aires - Argentina, Argentina
Research Site
Ramos Mejía, Buenos Aires Argentina, Argentina
Research Site
San Isidro, Buenos Aires- Argentina, Argentina
Research Site
Córdoba, Cordoba - Argentina, Argentina
Research Site
Salta, Salta Province, Argentina
Research Site
Rosario, Santa Fe- Argentina, Argentina
Research Site
San Miguel de Tucumán, Tucuman / Argentina, Argentina
Research Site
San Miguel de Tucumán, Tucuman-argentina, Argentina
Research Site
Alsemberg, Belgium, Belgium
Research Site
Anthée, Belgium, Belgium
Research Site
Auvelais, Belgium, Belgium
Research Site
Baisy-Thy, Belgium, Belgium
Research Site
Bertrix, Belgium, Belgium
Research Site
Betekom, Belgium, Belgium
Research Site
Boechout, Belgium, Belgium
Research Site
Braine-l'Alleud, Belgium, Belgium
Research Site
Burdinne, Belgium, Belgium
Research Site
Cerexhe-Heuseux, Belgium, Belgium
Research Site
Champion, Belgium, Belgium
Research Site
Chênée, Belgium, Belgium
Research Site
Comines, Belgium, Belgium
Research Site
Deurne (antwerpen), Belgium, Belgium
Research Site
Dour, Belgium, Belgium
Research Site
Embourg, Belgium, Belgium
Research Site
Genk, Belgium, Belgium
Research Site
Genly, Belgium, Belgium
Research Site
Gozée, Belgium, Belgium
Research Site
Grivegnée, Belgium, Belgium
Research Site
Halen, Belgium, Belgium
Research Site
Hasselt, Belgium, Belgium
Research Site
Heurne, Belgium, Belgium
Research Site
Heusden, Belgium, Belgium
Research Site
Hove, Belgium, Belgium
Research Site
Kessel-Lo, Belgium, Belgium
Research Site
Kraainem, Belgium, Belgium
Research Site
Landen, Belgium, Belgium
Research Site
Leopoldsburg, Belgium, Belgium
Research Site
Leuven, Belgium, Belgium
Research Site
Libin, Belgium, Belgium
Research Site
Linkebeek, Belgium, Belgium
Research Site
Lommel, Belgium, Belgium
Research Site
Marchienne-au-Pont, Belgium, Belgium
Research Site
Marchovelette, Belgium, Belgium
Research Site
Mechelen-aan-de-Maas, Belgium, Belgium
Research Site
Melsbroek, Belgium, Belgium
Research Site
Mont-sur-Marchienne, Belgium, Belgium
Research Site
Moorsel, Belgium, Belgium
Research Site
Mouscron, Belgium, Belgium
Research Site
Natoye, Belgium, Belgium
Research Site
Oostham, Belgium, Belgium
Research Site
Opgrimbie (maasmechelen), Belgium, Belgium
Research Site
Paal, Belgium, Belgium
Research Site
Puurs, Belgium, Belgium
Research Site
Ronquières, Belgium, Belgium
Research Site
Ronse, Belgium, Belgium
Research Site
Rumst, Belgium, Belgium
Research Site
Saint-Médard, Belgium, Belgium
Research Site
Sint-Gillis-Waas, Belgium, Belgium
Research Site
Steenokkerzeel, Belgium, Belgium
Research Site
Tavier, Belgium, Belgium
Research Site
Tessenderlo, Belgium, Belgium
Research Site
Thuin, Belgium, Belgium
Research Site
Tremelo, Belgium, Belgium
Research Site
Trois-Ponts, Belgium, Belgium
Research Site
Turnhout, Belgium, Belgium
Research Site
Vilvoorde, Belgium, Belgium
Research Site
Waremme, Belgium, Belgium
Research Site
Weerde, Belgium, Belgium
Research Site
Wezembeek-Oppem, Belgium, Belgium
Research Site
Zoersel, Belgium, Belgium
Research Site
Ans, Belgium
Research Site
Brussels, Belgium
Research Site
De Pinte, Belgium
Research Site
Ekeren, Belgium
Research Site
Evergem, Belgium
Research Site
Lauwe, Belgium
Research Site
Massemen, Belgium
Research Site
Moerkerke, Belgium
Research Site
Oudenaarde, Belgium
Research Site
Schoonaarde, Belgium
Research Site
Schuiferskapelle, Belgium
Research Site
Tielt, Belgium
Research Site
Maceió, Alagoas, Brazil
Research Site
Fortaleza, Ceará, Brazil
Research Site
Salvador, Estado de Bahia, Brazil
Research Site
Goiagoianiania, Goiás, Brazil
Research Site
Belo Horizonte, Minas Gerais, Brazil
Research Site
Rio de Janeiro, Rio de Janeiro, Brazil
Research Site
Passo Fundo, Rio Grande do Sul, Brazil
Research Site
Porto Alegre, Rio Grande do Sul, Brazil
Research Site
Botucatu, São Paulo, Brazil
Research Site
S.j.rio Preto, São Paulo, Brazil
Research Site
Santos, São Paulo, Brazil
Research Site
São José do Rio Preto, São Paulo, Brazil
Research Site
São Paulo, São Paulo, Brazil
Research Site
Campinas, Brazil
Research Site
Dimitrovgrad, Bulgaria
Research Site
Haskovo, Bulgaria
Research Site
Pleven, Bulgaria
Research Site
Plovdiv, Bulgaria
Research Site
Rousse, Bulgaria
Research Site
Sofia, Bulgaria
Research Site
Varna, Bulgaria
Research Site
Veliko Tarnovo, Bulgaria
Research Site
Calgary, Alberta, Canada
Research Site
Edmonton, Alberta, Canada
Research Site
Chilliwack, British Columbia, Canada
Research Site
Coquitlam, British Columbia, Canada
Research Site
Kelowna, British Columbia, Canada
Research Site
Langley, British Columbia, Canada
Research Site
New Westminster, British Columbia, Canada
Research Site
Penticton, British Columbia, Canada
Research Site
Surrey, British Columbia, Canada
Research Site
Victoria, British Columbia, Canada
Research Site
Portage la Prairie, Manitoba, Canada
Research Site
Winnipeg, Manitoba, Canada
Research Site
Grand Bay-Westfield, New Brunswick, Canada
Research Site
Moncton, New Brunswick, Canada
Research Site
Nackawic, New Brunswick, Canada
Research Site
Saint John, New Brunswick, Canada
Research Site
Woodstock, New Brunswick, Canada
Research Site
Bay Roberts, Newfoundland and Labrador, Canada
Research Site
Carbonear, Newfoundland and Labrador, Canada
Research Site
Conception Bay South, Newfoundland and Labrador, Canada
Research Site
Holyrood, Newfoundland and Labrador, Canada
Research Site
Mount Pearl, Newfoundland and Labrador, Canada
Research Site
St. John's, Newfoundland and Labrador, Canada
Research Site
Amherst, Nova Scotia, Canada
Research Site
Antigonish, Nova Scotia, Canada
Research Site
Digby, Nova Scotia, Canada
Research Site
Halifax, Nova Scotia, Canada
Research Site
Windsor, Nova Scotia, Canada
Research Site
Bolton, Ontario, Canada
Research Site
Brampton, Ontario, Canada
Research Site
Burlington, Ontario, Canada
Research Site
Cambridge, Ontario, Canada
Research Site
Corunna, Ontario, Canada
Research Site
Courtice, Ontario, Canada
Research Site
Etobicoke, Ontario, Canada
Research Site
Exeter, Ontario, Canada
Research Site
Greater Sudbury, Ontario, Canada
Research Site
Hamilton, Ontario, Canada
Research Site
Ingersoll, Ontario, Canada
Research Site
Kingston, Ontario, Canada
Research Site
London, Ontario, Canada
Research Site
Markham, Ontario, Canada
Research Site
Newmarket, Ontario, Canada
Research Site
Niagara Falls, Ontario, Canada
Research Site
North Bay, Ontario, Canada
Research Site
North York, Ontario, Canada
Research Site
Orléans, Ontario, Canada
Research Site
Oshawa, Ontario, Canada
Research Site
Ottawa, Ontario, Canada
Research Site
Perth, Ontario, Canada
Research Site
Peterborough, Ontario, Canada
Research Site
Renfrew, Ontario, Canada
Research Site
Saint Catherines, Ontario, Canada
Research Site
Sarnia, Ontario, Canada
Research Site
Scarborough Village, Ontario, Canada
Research Site
Smith Falls, Ontario, Canada
Research Site
Stirling, Ontario, Canada
Research Site
Thornhill, Ontario, Canada
Research Site
Thunder Bay, Ontario, Canada
Research Site
Tillsonburg, Ontario, Canada
Research Site
Toronto, Ontario, Canada
Research Site
Windsor, Ontario, Canada
Research Site
Woodstock, Ontario, Canada
Research Site
Charlottetown, Prince Edward Island, Canada
Research Site
Chicoutimi, Quebec, Canada
Research Site
Courcelette, Quebec, Canada
Research Site
Drummonville, Quebec, Canada
Research Site
Gatineau, Quebec, Canada
Research Site
Granby, Quebec, Canada
Research Site
Greenfield Park, Quebec, Canada
Research Site
LaSalle, Quebec, Canada
Research Site
Laval, Quebec, Canada
Research Site
Longueuil, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Pointe-Claire, Quebec, Canada
Research Site
Québec, Quebec, Canada
Research Site
Saint-Georges, Quebec, Canada
Research Site
Saint-Marc-des-Carrieres, Quebec, Canada
Research Site
Sainte-Catherine, Quebec, Canada
Research Site
Sainte-Julie, Quebec, Canada
Research Site
Sherbrooke, Quebec, Canada
Research Site
Trois-Rivières, Quebec, Canada
Research Site
Vanier, Quebec, Canada
Research Site
Regina, Saskatchewan, Canada
Research Site
Saskatoon, Saskatchewan, Canada
Research Site
Temuco, Región de la Araucanía, Chile
Research Site
Santiago, Santiago Metropolitan, Chile
Research Site
Medellín, Antioquia, Colombia
Research Site
Barranquilla, Atlántico, Colombia
Research Site
Bogotá, Colombia, Colombia
Research Site
Cartagena, Departamento de Bolívar, Colombia
Research Site
Pereira, Risaralda Department, Colombia
Research Site
Bucaramanga, Santander Department, Colombia
Research Site
Floridablanca, Santander Department, Colombia
Research Site
Cali, Valle del Cauca Department, Colombia
Research Site
Desamparados, Provincia de San José, Costa Rica
Research Site
Escazú, Provincia de San José, Costa Rica
Research Site
San Pedro, Provincia de San José, Costa Rica
Research Site
Heredia, Costa Rica
Research Site
Gentofte Municipality, Denmark
Research Site
Glostrup Municipality, Denmark
Research Site
Herlev, Denmark
Research Site
Hillerød, Denmark
Research Site
Odense C, Denmark
Research Site
El Salvador, San Salvador Department, El Salvador
Research Site
San Salvador, El Salvador
Research Site
Saku, Harju, Estonia
Research Site
Pärnu, Estonia
Research Site
Rakvere, Estonia
Research Site
Tallinn, Estonia
Research Site
Tartu, Estonia
Research Site
Viljandi County, Estonia
Research Site
Berlin, Germany
Research Site
Bochum, Germany
Research Site
Chemnitz, Germany
Research Site
Dortmund, Germany
Research Site
Dresden, Germany
Research Site
Frankfurt, Germany
Research Site
Görlitz, Germany
Research Site
Hamburg, Germany
Research Site
Künzing, Germany
Research Site
Leipzig, Germany
Research Site
Magdeburg, Germany
Research Site
Nuremberg, Germany
Research Site
Ulm, Germany
Research Site
Witten, Germany
Research Site
Kiryat Hadassah, Jerusalem, Israel
Research Site
Ashkelon Shore, Israel
Research Site
Beer Yakov, Israel
Research Site
Haifa, Israel
Research Site
Holon, Israel
Research Site
Jerusalem, Israel
Research Site
Kfar Saba, Israel
Research Site
Safed, Israel
Research Site
Tel Aviv, Israel
Research Site
Tel Litwinsky, Israel
Research Site
Zrifin, Israel
Research Site
Aguascalientes, Aguascalientes, Mexico
Research Site
Mexico City, D.F, Mexico
Research Site
Guadalajara, Jalisco, Mexico
Research Site
Monterrey, Nuevo León, Mexico
Research Site
San Luis Potosí City, San Luis Potosí, Mexico
Research Site
Culiacán, Sinaloa, Mexico
Research Site
Alkmaar, Netherlands
Research Site
Amersfoort, Netherlands
Research Site
Amsterdam, Netherlands
Research Site
Breda, Netherlands
Research Site
Deventer, Netherlands
Research Site
Eindhoven, Netherlands
Research Site
Gouda, Netherlands
Research Site
Groningen, Netherlands
Research Site
Hoorn, Netherlands
Research Site
Leiden, Netherlands
Research Site
Nijmegen, Netherlands
Research Site
Rotterdam, Netherlands
Research Site
The Hague, Netherlands
Research Site
Tilburg, Netherlands
Research Site
Utrecht, Netherlands
Research Site
Velp, Netherlands
Research Site
Zoetermeer, Netherlands
Research Site
Bekkestua, Norway
Research Site
Bergen, Norway
Research Site
Bøverbru, Norway
Research Site
Elverum, Norway
Research Site
Flatåsen, Norway
Research Site
Fredrikstad, Norway
Research Site
Halden, Norway
Research Site
Heimdal, Norway
Research Site
Kristiansand, Norway
Research Site
Laksevåg, Norway
Research Site
Lena, Norway
Research Site
Lierskogen, Norway
Research Site
Lysaker, Norway
Research Site
Løvenstad, Norway
Research Site
Moelv, Norway
Research Site
Moss, Norway
Research Site
Oslo, Norway
Research Site
Paradis, Norway
Research Site
Randaberg, Norway
Research Site
Rådal, Norway
Research Site
Skedsmokorset, Norway
Research Site
Ski, Norway
Research Site
Skiptvet, Norway
Research Site
Snaroya, Norway
Research Site
Sogndal, Norway
Research Site
Spikkestad, Norway
Research Site
Stavanger, Norway
Research Site
Strømmen, Norway
Research Site
Svelvik, Norway
Research Site
Trollåsen, Norway
Research Site
Trondheim, Norway
Research Site
Østerås, Norway
Research Site
Panama City, Provincia de Panamá, Panama
Research Site
Aleksandrów Łódzki, Poland
Research Site
Bydgoszcz, Poland
Research Site
Bytom, Poland
Research Site
Chodzież, Poland
Research Site
Chorzów, Poland
Research Site
Gdansk, Poland
Research Site
Gliwice, Poland
Research Site
Jelcz Laskowice, Poland
Research Site
Karpacz, Poland
Research Site
Katowice, Poland
Research Site
Koluszki, Poland
Research Site
Krakow, Poland
Research Site
Linia, Poland
Research Site
Lodz, Poland
Research Site
Lublin, Poland
Research Site
Nowogard, Poland
Research Site
Olsztyn, Poland
Research Site
Opalenica, Poland
Research Site
Opole, Poland
Research Site
Ostrów Wielkopolski, Poland
Research Site
Oława, Poland
Research Site
Piekary Śląskie, Poland
Research Site
Poznan, Poland
Research Site
Puławy, Poland
Research Site
Radom, Poland
Research Site
Radziejów, Poland
Research Site
Rybnik, Poland
Research Site
Sieradz, Poland
Research Site
Skierniewice, Poland
Research Site
Sobótka, Poland
Research Site
Sopot, Poland
Research Site
Szczecin, Poland
Research Site
Słupca, Poland
Research Site
Tarnów, Poland
Research Site
Torun, Poland
Research Site
Trzcianka, Poland
Research Site
Turek, Poland
Research Site
Warsaw, Poland
Research Site
Wąbrzeźno, Poland
Research Site
Wejherowo, Poland
Research Site
Wroclaw, Poland
Research Site
Zabrze, Poland
Research Site
Aguas Buenas, Puerto Rico
Research Site
Caguas, Puerto Rico
Research Site
Cidra, Puerto Rico
Research Site
Levittown-toa Baja, Puerto Rico
Research Site
Ponce, Puerto Rico
Research Site
San Juan, Puerto Rico
Research Site
Cluj-Napoca, Cluj, Romania
Research Site
Timișoara, Timiș County, Romania
Research Site
Brasov, Romania
Research Site
Bucharest, Romania
Research Site
Kemerovo, Russia
Research Site
Krasnoyarsk, Russia
Research Site
Moscow, Russia
Research Site
Novosibirsk, Russia
Research Site
Saint Petersburg, Russia
Research Site
Saratov, Russia
Research Site
Tolyatti, Russia
Research Site
Tomsk, Russia
Research Site
Tyumen, Russia
Research Site
Voronezh, Russia
Research Site
Yaroslavl, Russia
Research Site
Yekaterinburg, Russia
Research Site
Claremont, Cape Province, South Africa
Research Site
Athlone, Cape Town, South Africa
Research Site
Florida Park, Gauteng, South Africa
Research Site
Lenasia, Gauteng, South Africa
Research Site
Pretoria, Gauteng, South Africa
Research Site
Witbank, Gauteng, South Africa
Research Site
Durban, KwaZulu-Natal, South Africa
Research Site
eMkhomazi, KwaZulu-Natal, South Africa
Research Site
Morningside Manor, Morningside, South Africa
Research Site
Korsten, Port Elizabeth, South Africa
Research Site
Hillcrest, Pretoria, South Africa
Research Site
Halfway House, South Africa, South Africa
Research Site
Johannesburg, South Africa, South Africa
Research Site
Worcester, South Africa, South Africa
Research Site
Benoni, South Africa
Research Site
Lakeview, Retreat, South Africa
Research Site
Rustenburg, South Africa
Research Site
Somerset West, South Africa
Research Site
Vanderbijlpark, South Africa
Research Site
Olten, Schweiz, Switzerland
Research Site
Reading, Berkshire, United Kingdom
Research Site
Annan, Dumfries and Galloway, United Kingdom
Research Site
Blantyre, Lanarkshire, United Kingdom
Research Site
Hamilton, Lanarkshire, United Kingdom
Research Site
Strathaven, Lanarkshire, United Kingdom
Research Site
Wishaw, Lanarkshire, United Kingdom
Research Site
Paisley, Renfrewshire, United Kingdom
Research Site
Airdrie, Scotland, United Kingdom
Research Site
Glasgow, Scotland, United Kingdom
Research Site
Barrhead, United Kingdom
Research Site
Bellshill, United Kingdom
Research Site
Birmingham, United Kingdom
Research Site
Cambuslang, United Kingdom
Research Site
Cardiff, United Kingdom
Research Site
Chorley, United Kingdom
Research Site
Cumbernauld, United Kingdom
Research Site
Gourock, United Kingdom
Research Site
Greenock, United Kingdom
Research Site
Helensburgh, United Kingdom
Research Site
Kirkintilloch, United Kingdom
Research Site
Liverpool, United Kingdom
Research Site
Lockerbie, United Kingdom
Research Site
Manchester, United Kingdom
Research Site
New Stevenson, United Kingdom
Research Site
Renfrew, United Kingdom
Research Site
Stranraer, United Kingdom
Research Site
Strathblane, United Kingdom
Research Site
Thornhill, United Kingdom
Research Site
Wolverhampton, United Kingdom
Research Site
Montevideo, Uruguay
Research Site
Maracay, Municipio Girardot, Aragua, Venezuela
Research Site
Barinas, Barinas, Venezuela
Research Site
Ciudad Bolívar, Bolívar, Venezuela
Research Site
Puerto Ordaz and San Felix, Bolívar, Venezuela
Research Site
Valencia, Carabobo, Venezuela
Research Site
Barquisimeto, Lara, Venezuela
Research Site
Latrinidad Caracas, Municipio Baruta, Venezuela
Research Site
Mérida, Mérida, Venezuela
Research Site
Porlamar, Nueva Esparta, Venezuela
Research Site
Punto Fijo, Estado Falcon, Venezuela, Venezuela
Research Site
Maracaibo, Zulia, Venezuela
Research Site
Caracas, Venezuela
Related Publications (32)
Hoshi RA, Alotaibi M, Liu Y, Watrous JD, Ridker PM, Glynn RJ, Serhan CN, Luttmann-Gibson H, Moorthy MV, Jain M, Demler OV, Mora S. One-Year Effects of High-Intensity Statin on Bioactive Lipids: Findings From the JUPITER Trial. Arterioscler Thromb Vasc Biol. 2024 Jul;44(7):e196-e206. doi: 10.1161/ATVBAHA.124.321058. Epub 2024 Jun 6.
PMID: 38841856DERIVEDTunnicliffe DJ, Palmer SC, Cashmore BA, Saglimbene VM, Krishnasamy R, Lambert K, Johnson DW, Craig JC, Strippoli GF. HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis. Cochrane Database Syst Rev. 2023 Nov 29;11(11):CD007784. doi: 10.1002/14651858.CD007784.pub3.
PMID: 38018702DERIVEDAjala ON, Demler OV, Liu Y, Farukhi Z, Adelman SJ, Collins HL, Ridker PM, Rader DJ, Glynn RJ, Mora S. Anti-Inflammatory HDL Function, Incident Cardiovascular Events, and Mortality: A Secondary Analysis of the JUPITER Randomized Clinical Trial. J Am Heart Assoc. 2020 Sep;9(17):e016507. doi: 10.1161/JAHA.119.016507. Epub 2020 Aug 15.
PMID: 32799709DERIVEDAkinkuolie AO, Lawler PR, Chu AY, Caulfield M, Mu J, Ding B, Nyberg F, Glynn RJ, Ridker PM, Hurt-Camejo E, Chasman DI, Mora S. Group IIA Secretory Phospholipase A2, Vascular Inflammation, and Incident Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1182-1190. doi: 10.1161/ATVBAHA.118.311894.
PMID: 31070471DERIVEDDagenais GR, Jung H, Lonn E, Bogaty PM, Dehghan M, Held C, Avezum A, Jansky P, Keltai M, Leiter LA, Lopez-Jaramillo P, Toff WD, Bosch J, Yusuf S. Effects of Lipid-Lowering and Antihypertensive Treatments in Addition to Healthy Lifestyles in Primary Prevention: An Analysis of the HOPE-3 Trial. J Am Heart Assoc. 2018 Jul 22;7(15):e008918. doi: 10.1161/JAHA.118.008918.
PMID: 30033433DERIVEDKhera AV, Demler OV, Adelman SJ, Collins HL, Glynn RJ, Ridker PM, Rader DJ, Mora S. Cholesterol Efflux Capacity, High-Density Lipoprotein Particle Number, and Incident Cardiovascular Events: An Analysis From the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin). Circulation. 2017 Jun 20;135(25):2494-2504. doi: 10.1161/CIRCULATIONAHA.116.025678. Epub 2017 Apr 27.
PMID: 28450350DERIVEDAkinkuolie AO, Glynn RJ, Padmanabhan L, Ridker PM, Mora S. Circulating N-Linked Glycoprotein Side-Chain Biomarker, Rosuvastatin Therapy, and Incident Cardiovascular Disease: An Analysis From the JUPITER Trial. J Am Heart Assoc. 2016 Jul 13;5(7):e003822. doi: 10.1161/JAHA.116.003822.
PMID: 27413042DERIVEDDugani SB, Akinkuolie AO, Paynter N, Glynn RJ, Ridker PM, Mora S. Association of Lipoproteins, Insulin Resistance, and Rosuvastatin With Incident Type 2 Diabetes Mellitus : Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. 2016 May 1;1(2):136-45. doi: 10.1001/jamacardio.2016.0096.
PMID: 27347563DERIVEDLawler PR, Akinkuolie AO, Chandler PD, Moorthy MV, Vandenburgh MJ, Schaumberg DA, Lee IM, Glynn RJ, Ridker PM, Buring JE, Mora S. Circulating N-Linked Glycoprotein Acetyls and Longitudinal Mortality Risk. Circ Res. 2016 Apr 1;118(7):1106-15. doi: 10.1161/CIRCRESAHA.115.308078. Epub 2016 Mar 7.
PMID: 26951635DERIVEDMora S, Caulfield MP, Wohlgemuth J, Chen Z, Superko HR, Rowland CM, Glynn RJ, Ridker PM, Krauss RM. Atherogenic Lipoprotein Subfractions Determined by Ion Mobility and First Cardiovascular Events After Random Allocation to High-Intensity Statin or Placebo: The Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) Trial. Circulation. 2015 Dec 8;132(23):2220-9. doi: 10.1161/CIRCULATIONAHA.115.016857. Epub 2015 Sep 25.
PMID: 26408274DERIVEDChu AY, Giulianini F, Barratt BJ, Ding B, Nyberg F, Mora S, Ridker PM, Chasman DI. Differential Genetic Effects on Statin-Induced Changes Across Low-Density Lipoprotein-Related Measures. Circ Cardiovasc Genet. 2015 Oct;8(5):688-95. doi: 10.1161/CIRCGENETICS.114.000962. Epub 2015 Aug 13.
PMID: 26273092DERIVEDEverett BM, Zeller T, Glynn RJ, Ridker PM, Blankenberg S. High-sensitivity cardiac troponin I and B-type natriuretic Peptide as predictors of vascular events in primary prevention: impact of statin therapy. Circulation. 2015 May 26;131(21):1851-60. doi: 10.1161/CIRCULATIONAHA.114.014522. Epub 2015 Mar 30.
PMID: 25825410DERIVEDEverett BM, Mora S, Glynn RJ, MacFadyen J, Ridker PM. Safety profile of subjects treated to very low low-density lipoprotein cholesterol levels (<30 mg/dl) with rosuvastatin 20 mg daily (from JUPITER). Am J Cardiol. 2014 Dec 1;114(11):1682-9. doi: 10.1016/j.amjcard.2014.08.041. Epub 2014 Sep 16.
PMID: 25439449DERIVEDPena JM, Aspberg S, MacFadyen J, Glynn RJ, Solomon DH, Ridker PM. Statin therapy and risk of fracture: results from the JUPITER randomized clinical trial. JAMA Intern Med. 2015 Feb;175(2):171-7. doi: 10.1001/jamainternmed.2014.6388.
PMID: 25437881DERIVEDKhera AV, Everett BM, Caulfield MP, Hantash FM, Wohlgemuth J, Ridker PM, Mora S. Lipoprotein(a) concentrations, rosuvastatin therapy, and residual vascular risk: an analysis from the JUPITER Trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin). Circulation. 2014 Feb 11;129(6):635-42. doi: 10.1161/CIRCULATIONAHA.113.004406. Epub 2013 Nov 17.
PMID: 24243886DERIVEDMora S, Glynn RJ, Ridker PM. High-density lipoprotein cholesterol, size, particle number, and residual vascular risk after potent statin therapy. Circulation. 2013 Sep 10;128(11):1189-97. doi: 10.1161/CIRCULATIONAHA.113.002671. Epub 2013 Sep 3.
PMID: 24002795DERIVEDRidker PM, Pradhan A, MacFadyen JG, Libby P, Glynn RJ. Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial. Lancet. 2012 Aug 11;380(9841):565-71. doi: 10.1016/S0140-6736(12)61190-8.
PMID: 22883507DERIVEDMora S, Glynn RJ, Boekholdt SM, Nordestgaard BG, Kastelein JJ, Ridker PM. On-treatment non-high-density lipoprotein cholesterol, apolipoprotein B, triglycerides, and lipid ratios in relation to residual vascular risk after treatment with potent statin therapy: JUPITER (justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin). J Am Coll Cardiol. 2012 Apr 24;59(17):1521-8. doi: 10.1016/j.jacc.2011.12.035.
PMID: 22516441DERIVEDStein EA, Vidt DG, Shepherd J, Cain VA, Anzalone D, Cressman MD. Renal safety of intensive cholesterol-lowering treatment with rosuvastatin: a retrospective analysis of renal adverse events among 40,600 participants in the rosuvastatin clinical development program. Atherosclerosis. 2012 Apr;221(2):471-7. doi: 10.1016/j.atherosclerosis.2011.12.011. Epub 2012 Jan 3.
PMID: 22304793DERIVEDDorresteijn JA, Visseren FL, Ridker PM, Wassink AM, Paynter NP, Steyerberg EW, van der Graaf Y, Cook NR. Estimating treatment effects for individual patients based on the results of randomised clinical trials. BMJ. 2011 Oct 3;343:d5888. doi: 10.1136/bmj.d5888.
PMID: 21968126DERIVEDAlbert MA, Glynn RJ, Fonseca FA, Lorenzatti AJ, Ferdinand KC, MacFadyen JG, Ridker PM. Race, ethnicity, and the efficacy of rosuvastatin in primary prevention: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. Am Heart J. 2011 Jul;162(1):106-14.e2. doi: 10.1016/j.ahj.2011.03.032. Epub 2011 Jun 12.
PMID: 21742096DERIVEDRidker PM, MacFadyen JG, Glynn RJ, Chasman DI. Kinesin-like protein 6 (KIF6) polymorphism and the efficacy of rosuvastatin in primary prevention. Circ Cardiovasc Genet. 2011 Jun;4(3):312-7. doi: 10.1161/CIRCGENETICS.110.959353. Epub 2011 Apr 14.
PMID: 21493817DERIVEDKoenig W, Ridker PM. Rosuvastatin for primary prevention in patients with European systematic coronary risk evaluation risk >/= 5% or Framingham risk >20%: post hoc analyses of the JUPITER trial requested by European health authorities. Eur Heart J. 2011 Jan;32(1):75-83. doi: 10.1093/eurheartj/ehq370. Epub 2010 Oct 22.
PMID: 20971747DERIVEDRidker PM, Macfadyen JG, Nordestgaard BG, Koenig W, Kastelein JJ, Genest J, Glynn RJ. Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for "intermediate risk". Circ Cardiovasc Qual Outcomes. 2010 Sep;3(5):447-52. doi: 10.1161/CIRCOUTCOMES.110.938118. Epub 2010 Aug 24.
PMID: 20736443DERIVEDRidker PM, Genest J, Boekholdt SM, Libby P, Gotto AM, Nordestgaard BG, Mora S, MacFadyen JG, Glynn RJ, Kastelein JJ; JUPITER Trial Study Group. HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial. Lancet. 2010 Jul 31;376(9738):333-9. doi: 10.1016/S0140-6736(10)60713-1. Epub 2010 Jul 23.
PMID: 20655105DERIVEDRidker PM, MacFadyen J, Cressman M, Glynn RJ. Efficacy of rosuvastatin among men and women with moderate chronic kidney disease and elevated high-sensitivity C-reactive protein: a secondary analysis from the JUPITER (Justification for the Use of Statins in Prevention-an Intervention Trial Evaluating Rosuvastatin) trial. J Am Coll Cardiol. 2010 Mar 23;55(12):1266-1273. doi: 10.1016/j.jacc.2010.01.020. Epub 2010 Mar 4.
PMID: 20206456DERIVEDMora S, Glynn RJ, Hsia J, MacFadyen JG, Genest J, Ridker PM. Statins for the primary prevention of cardiovascular events in women with elevated high-sensitivity C-reactive protein or dyslipidemia: results from the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and meta-analysis of women from primary prevention trials. Circulation. 2010 Mar 9;121(9):1069-77. doi: 10.1161/CIRCULATIONAHA.109.906479. Epub 2010 Feb 22.
PMID: 20176986DERIVEDRidker PM, MacFadyen JG, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group. Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin (JUPITER). Circ Cardiovasc Qual Outcomes. 2009 Nov;2(6):616-23. doi: 10.1161/CIRCOUTCOMES.109.848473. Epub 2009 Sep 22.
PMID: 20031900DERIVEDEverett BM, Glynn RJ, MacFadyen JG, Ridker PM. Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive protein: justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER). Circulation. 2010 Jan 5;121(1):143-50. doi: 10.1161/CIRCULATIONAHA.109.874834. Epub 2009 Dec 21.
PMID: 20026779DERIVEDGlynn RJ, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Ridker PM. A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med. 2009 Apr 30;360(18):1851-61. doi: 10.1056/NEJMoa0900241. Epub 2009 Mar 29.
PMID: 19329822DERIVEDRidker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, Macfadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Trial Study Group. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet. 2009 Apr 4;373(9670):1175-82. doi: 10.1016/S0140-6736(09)60447-5. Epub 2009 Mar 28.
PMID: 19329177DERIVEDRidker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008 Nov 20;359(21):2195-207. doi: 10.1056/NEJMoa0807646. Epub 2008 Nov 9.
PMID: 18997196DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Torbjorn Lundstrom
- Organization
- AstraZeneca
Study Officials
- STUDY DIRECTOR
Judith Hsia, MD
AstraZeneca
- STUDY CHAIR
Paul Ridker, MD
Brigham and Women's Hospital
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 13, 2005
First Posted
October 17, 2005
Study Start
February 1, 2003
Primary Completion
September 1, 2008
Study Completion
September 1, 2008
Last Updated
March 24, 2014
Results First Posted
March 24, 2014
Record last verified: 2014-02