Immuno 1: Immune Reconstitution Following Conventional or High-Dose Chemotherapy With Stem Cell Transplant

NCT00231712 | Unknown

• 1 other identifier: 133/04
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to conduct an analysis of the influences of

1. 1.conventional chemotherapy
2. 2.high-dose chemotherapy followed by autologous stem cell transplant
3. 3.high-dose chemotherapy followed by allogeneic stem cell transplant on the recovery of the immune system.

Conditions

Leukemia; Medulloblastoma

Keywords

prospective analysis of immune function,; spectratype; immunoscope; TREC analysis; solid tumor

Eligibility Criteria

• Age: 0 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Acute leukemia treated according to current ALL-BFM 2002 protocol
• Solid tumor treated according to current GPOH-protocol
• Medulloblastoma treated according to HIT-2000 protocol
• High-dose chemotherapy followed by autologous stem cell transplantation
• High-dose chemotherapy followed by allogeneic stem cell transplantation
• Written consent according to our institutional guidelines

You may not qualify if:

• No written consent

Sponsors & Collaborators

• Julius-Maximilians University: lead
• University of Wuerzburg: collaborator

Study Sites (1)

University Children's Hospital Pedaitric Oncology

Würzburg, D97080, Germany

RECRUITING

Related Publications (3)

• Eyrich M, Wollny G, Tzaribaschev N, Dietz K, Brugger D, Bader P, Lang P, Schilbach K, Winkler B, Niethammer D, Schlegel PG. Onset of thymic recovery and plateau of thymic output are differentially regulated after stem cell transplantation in children. Biol Blood Marrow Transplant. 2005 Mar;11(3):194-205. doi: 10.1016/j.bbmt.2004.12.001.

  PMID: 15744238 BACKGROUND

• Eyrich M, Leiler C, Lang P, Schilbach K, Schumm M, Bader P, Greil J, Klingebiel T, Handgretinger R, Niethammer D, Schlegel PG. A prospective comparison of immune reconstitution in pediatric recipients of positively selected CD34+ peripheral blood stem cells from unrelated donors vs recipients of unmanipulated bone marrow from related donors. Bone Marrow Transplant. 2003 Aug;32(4):379-90. doi: 10.1038/sj.bmt.1704158.

  PMID: 12900774 BACKGROUND

• Eyrich M, Croner T, Leiler C, Lang P, Bader P, Klingebiel T, Niethammer D, Schlegel PG. Distinct contributions of CD4(+) and CD8(+) naive and memory T-cell subsets to overall T-cell-receptor repertoire complexity following transplantation of T-cell-depleted CD34-selected hematopoietic progenitor cells from unrelated donors. Blood. 2002 Sep 1;100(5):1915-8. doi: 10.1182/blood-2001-11-0005.

  PMID: 12176918 BACKGROUND

MeSH Terms

Conditions

Leukemia; Medulloblastoma

Condition Hierarchy (Ancestors)

Neoplasms by Histologic Type; Neoplasms; Hematologic Diseases; Hemic and Lymphatic Diseases; Glioma; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neuroectodermal Tumors, Primitive; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue

Study Officials

• Paul G Schlegel, MD

  University Children's Hospital Pediatric Oncology Wuerzburg / Germany

  PRINCIPAL INVESTIGATOR

• Matthias Eyrich, MD

  Pediatric Stem Cell Transplant Program

  STUDY DIRECTOR

Central Study Contacts

Paul G Schlegel, MD

CONTACT

+49 - 931 - 201 - 27831; schlegel@mail.uni-wuerzburg.de

Beate Winkler, MD

CONTACT

49 - 931 - 201 - 27831; winkler_b@klinik.uni-wuerzburg.de

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 30, 2005
• First Posted: October 4, 2005
• Study Start: March 1, 2005
• Study Completion: February 1, 2009
• Last Updated: August 23, 2006

Record last verified: 2005-09

Locations

DE (1)