Investigation of Coagulation Parameters in Hereditary Haemorrhagic Telangiectasia

NCT00230659 | Completed

• 1 other identifier: IC/CLS6
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

We will address coagulation parameters in hereditary haemorrhagic telangiectasia (HHT) compared to controls.

Conditions

Telangiectasia, Hereditary Hemorrhagic

Study Arms (2)

HHT patients

Patients with hereditary haemorrhagic telangiectasia. Blood sample to be taken.

Other: Blood sample to be taken.

Controls

People without hereditary haemorrhagic telangiectasia. Blood sample to be taken.

Other: Blood sample to be taken.

Interventions

Blood sample to be taken. OTHER

Blood sample to be taken.

Controls; HHT patients

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

'Patients with HHT' have a clinical diagnosis of hereditary haemorrhagic telangiectasia (HHT) 'Normal controls' have NO clinical diagnosis of hereditary haemorrhagic telangiectasia (HHT), and are not blood relatives of someone with HHT."

You may qualify if:

• Patients with HHT and normal controls

You may not qualify if:

• Previous thrombosis, recent ill health

Sponsors & Collaborators

• Imperial College London: lead
• Hammersmith Hospitals NHS Trust: collaborator

Study Sites (1)

Imperial College Hammersmith Campus

London, W12 0NN, United Kingdom

Location

Related Publications (3)

• Shovlin CL, Sulaiman NL, Govani FS, Jackson JE, Begbie ME. Elevated factor VIII in hereditary haemorrhagic telangiectasia (HHT): association with venous thromboembolism. Thromb Haemost. 2007 Nov;98(5):1031-9.

  PMID: 18000608 RESULT

• Livesey JA, Manning RA, Meek JH, Jackson JE, Kulinskaya E, Laffan MA, Shovlin CL. Low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and pulmonary emboli/deep venous thromboses in replicate cohorts of patients with hereditary haemorrhagic telangiectasia. Thorax. 2012 Apr;67(4):328-33. doi: 10.1136/thoraxjnl-2011-201076. Epub 2011 Dec 14.

  PMID: 22169361 RESULT

• Shovlin CL, Chamali B, Santhirapala V, Livesey JA, Angus G, Manning R, Laffan MA, Meek J, Tighe HC, Jackson JE. Ischaemic strokes in patients with pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia: associations with iron deficiency and platelets. PLoS One. 2014 Feb 19;9(2):e88812. doi: 10.1371/journal.pone.0088812. eCollection 2014.

  PMID: 24586400 RESULT

Biospecimen

Retention: SAMPLES WITHOUT DNA

Plasma sample aliquots.

MeSH Terms

Conditions

Telangiectasia, Hereditary Hemorrhagic

Condition Hierarchy (Ancestors)

Hemostatic Disorders; Vascular Diseases; Cardiovascular Diseases; Telangiectasis; Hemorrhagic Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Vascular Malformations; Cardiovascular Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Claire Shovlin

  Imperial College London

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 29, 2005
• First Posted: October 3, 2005
• Study Start: August 1, 2004
• Primary Completion: July 1, 2007
• Study Completion: July 1, 2008
• Last Updated: September 28, 2023

Record last verified: 2023-09

Locations

GB (1)