The Effect of Aerobic Exercise on Learning After Stroke
Effect of Cardiovascular Fitness on Motor Learning and Executive Function in Individuals After Stroke
2 other identifiers
interventional
38
1 country
1
Brief Summary
Determine if attaining aerobic fitness is beneficial in producing cortical neuroplasticity in individuals with chronic stroke.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_1 stroke
Started Sep 2005
Longer than P75 for phase_1 stroke
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2005
CompletedFirst Submitted
Initial submission to the registry
September 26, 2005
CompletedFirst Posted
Study publicly available on registry
September 28, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2009
CompletedMay 1, 2012
April 1, 2012
3.3 years
September 26, 2005
April 27, 2012
Conditions
Outcome Measures
Primary Outcomes (1)
Motor learning behavioral measures; executive function behavioral measures.
Baseline, 8 weeks, 12 weeks
Secondary Outcomes (1)
Peak V02 and other aerobic capacity measures. Physical disability measures.
Baseline, 8 weeks, 12 weeks
Study Arms (2)
1
EXPERIMENTAL2
NO INTERVENTIONControl Group
Interventions
Eligibility Criteria
You may qualify if:
- Single ischemic stroke occuring 6-72 months prior
- Fugl-Meyer score (upper + lower extremity) 45 or greater
- Mini mental status score of \>23
- approval of the subject's medical doctor
You may not qualify if:
- already performing \>20 min of cardiovascular exercise 3x/wk or more
- alcohol consumption of \>2 oz. liquor, 8 oz. wine or 24 oz beer/day
- cardiac history of unstable angina, recent myocardia infarction within the last 3 months, congestive heart failure, significant valve dysfunction
- medical history of recent hospitalization (\> 3 months) for medical illness
- symptomatic peripheral arterial occlusive disease
- orthopedic or chronic pain conditions restricting exercise
- pulmonary or renal failure
- active cancer
- unstable hypertension (\>160/100 mmHg)
- diabetes mellitus (fasting glucose \> 180 NG./dk, HgA1C \> 10%) that is unable to be controlled \< month
- receptive or expressive aphasia as indicated on MMSE
- multiple strokes or other neuromuscular conditions
- major depression that is untreated using the Beck depression inventory
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Kansaslead
- American Heart Associationcollaborator
Study Sites (1)
University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Barbara Quaney, PT, PhD
University of Kansas Medical Center
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 26, 2005
First Posted
September 28, 2005
Study Start
September 1, 2005
Primary Completion
December 1, 2008
Study Completion
December 1, 2009
Last Updated
May 1, 2012
Record last verified: 2012-04