NCT00215228|CompletedPhase 2/3
Effects of Duloxetine vs. Escitalopram on Heart Rate Variability in Depression
Effects of Escitalopram vs. Duloxetine on Heart Rate Variability and Autonomic Cardiovascular Control
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Effects of Escitalopram vs. Duloxetine on Heart Rate Variability and Autonomic Cardiovascular Control
Sponsor study identifier
Secondary identifiers
OTHER · DUMC
interventional
26
1 country
1
Study Start
July 2005
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
August 2007
Actual (reported)Low heart rate variability is a marker of increased risk of cardiac mortality, and is observed in depressed coronary artery disease patients. Some antidepressants may themselves, however, decrease heart rate variability. We will test the hypothesis that greater reduction in heart rate variability will be associated with duloxetine (which has noradrenergic activity) than escitalopram (a selective serotonin reuptake inhibitor). We will also test the hypothesis that changes in heart rate variability are related to the magnitude of norepinephrine transporter occupancy.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2007
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 2005
Date type not reportedThis date has not been verified as actual or estimated.
September 20, 2005
Actual (reported)September 22, 2005
Actual (reported)August 2007
Actual (reported)Effect of treatment on heart rate variability
Effect of treatment on affective variables (depression, anxiety, stress reactivity)
Effect of treatment on neurotransmitter transporter occupancy
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Duke University Medical Center
Durham, North Carolina, 27705, United States
Wei Zhang, M.D., Ph. D
Duke University
First Submitted
September 20, 2005
First Posted
September 22, 2005
Study Start
July 2005
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
August 2007
Actual (reported)Contact the study team to confirm eligibility.
Last Updated
July 21, 2014
Record last verified: 2007-09
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Source: ClinicalTrials.gov.
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