Treatment of Reduced Heart Rate Variability Associated With Major Depression With Electroconvulsive Therapy
A Means to Enhanced Cardiovascular Outcomes: Reduction of Exaggerated Platelet Activity Through Treatment of Depression.
2 other identifiers
observational
50
1 country
1
Brief Summary
The purpose of this study is to evaluate alterations in sympathetic tone in patients with major depression with and without ischemic heart disease and then to reevaluate these patients after 8 treatments with electroconvulsive therapy(ECT). We expect to support the hypothesis that HRV are pathophysiologically associated with the state of major depression. We hypothesize the following:
- 1.Heart rate variability (HRV) will be decreased prior to treatment of depression in comparison to post-treatment measures of HRV.
- 2.After 8 treatments with ECT, HRV will be increased under basal conditions.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Nov 1998
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 1998
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2005
CompletedFirst Submitted
Initial submission to the registry
September 14, 2005
CompletedFirst Posted
Study publicly available on registry
September 21, 2005
CompletedNovember 19, 2013
November 1, 2013
September 14, 2005
November 17, 2013
Conditions
Keywords
Eligibility Criteria
Patients with major depressive disorder presenting for a course of electroconvulsive therapy.
You may not qualify if:
- Patients will not be accepted into the study if they abuse alcohol or drugs.
- Patients will be excluded from the study if they have had an MI within the past three months, unstable crescendo angina or ongoing warfarin treatment
- Patients also will not be accepted into the study if ECT will be harmful to them. These patients include:
- those who have had a recent MI (\<3 months)
- those who have an infection of the brain,
- those who have a condition in which there is increased intracranial pressure (e.g. a brain tumor)
- those who cannot tolerate general anesthesia.
- Any patient with a current DSM-IV Axis I diagnosis other than major depression will be excluded from the study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Emory Universitylead
- The Dana Foundationcollaborator
Study Sites (1)
Emory University School of Medicine
Atlanta, Georgia, 30322, United States
Related Publications (1)
Royster EB, Trimble LM, Cotsonis G, Schmotzer B, Manatunga A, Rushing NN, Pagnoni G, Auyeung SF, Brown AR, Schoenbeck J, Murthy S, McDonald WM, Musselman DL. Changes in heart rate variability of depressed patients after electroconvulsive therapy. Cardiovasc Psychiatry Neurol. 2012;2012:794043. doi: 10.1155/2012/794043. Epub 2012 Aug 27.
PMID: 22966422RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Dominique L Musselman, MD,MS
Emory University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
September 14, 2005
First Posted
September 21, 2005
Study Start
November 1, 1998
Study Completion
April 1, 2005
Last Updated
November 19, 2013
Record last verified: 2013-11