Study Of PHarmacogenetics in Ethnically Diverse Populations (SOPHIE Study)

NCT00187668 | Completed DMC

• 1 other identifier: 701
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Collect DNA from well-characterized healthy volunteers.

Conditions

Focus Groups

Keywords

Healthy Cohort

Outcome Measures

Primary Outcomes (1)

• Healthy Control

  Amass a cohort of healthy controls to be used for future genotype to phenotype studies.

  On-going

Study Arms (4)

African American

Must self identify as African American with parents and grandparents of the same ethnicity. Must be healthy taking no over the counter medications or prescription medications.

Cuacasian

Must self identify as Caucasian with parents and grandparents of the same ethnicity. Must be healthy taking no over the counter medications or prescription medications.

Hispanic

Must self identify as Hispanic with parents and grandparents of the same ethnicity. Must be healthy taking no over the counter medications or prescription medications.

Asian

Must self identify as Asian with parents and grandparents of the same ethnicity. Must be healthy taking no over the counter medications or prescription medications.

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Healthy participants that are willing to be called back for subsequent genotype to phenotype studies.

You may qualify if:

• Healthy adult subjects of both genders and specified ethnic groups
• Subjects must be between 18-40 years of age

You may not qualify if:

• Smokers
• Drink \> 2 alcoholic beverages/day
• Take any chronic medication

Sponsors & Collaborators

• University of California, San Francisco: lead

Study Sites (1)

San Francisco General Hopsital CTSI CRC

San Francisco, California, 94143, United States

Location

Related Publications (7)

• Ha Choi J, Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, Hesselson S, Castro RA, Stryke D, Johns SJ, Kwok PY, Ferrin TE, Goo Lee M, Black BL, Ahituv N, Giacomini KM. Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1. Pharmacogenet Genomics. 2009 Oct;19(10):770-80. doi: 10.1097/FPC.0b013e328330eeca.

  PMID: 19745787 BACKGROUND

• Urban TJ, Sebro R, Hurowitz EH, Leabman MK, Badagnani I, Lagpacan LL, Risch N, Giacomini KM. Functional genomics of membrane transporters in human populations. Genome Res. 2006 Feb;16(2):223-30. doi: 10.1101/gr.4356206. Epub 2005 Dec 14.

  PMID: 16354753 BACKGROUND

• Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM; Pharmacogenetics Of Membrane Transporters Investigators. Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5902-7. doi: 10.1073/pnas.0730858100. Epub 2003 Apr 28.

  PMID: 12719534 BACKGROUND

• Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Carlson EJ, Herskowitz I, Giacomini KM, Clark AG; Pharmacogenetics of Membrane Transporters Investigators. Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics. 2003 Aug;13(8):481-94. doi: 10.1097/00008571-200308000-00006.

  PMID: 12893986 BACKGROUND

• Gray JH, Mangravite LM, Owen RP, Urban TJ, Chan W, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM. Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations. Mol Pharmacol. 2004 Mar;65(3):512-9. doi: 10.1124/mol.65.3.512.

  PMID: 14978229 BACKGROUND

• Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Pharmacogenomics J. 2005;5(3):157-65. doi: 10.1038/sj.tpj.6500303.

  PMID: 15738947 BACKGROUND

• Owen RP, Gray JH, Taylor TR, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM. Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. Pharmacogenet Genomics. 2005 Feb;15(2):83-90. doi: 10.1097/01213011-200502000-00004.

  PMID: 15861032 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

40 mL of blood for DNA extraction

Study Officials

• Kathleen M Giacomini, PhD

  University of California, San Francisco

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 13, 2005
• First Posted: September 16, 2005
• Study Start: February 1, 2004
• Primary Completion: August 1, 2023
• Study Completion: August 1, 2023
• Last Updated: August 14, 2023

Record last verified: 2023-08

Locations

US (1)