Effect of Antiseizure Medication on Hormone Levels and Sexual Function in Men With Epilepsy
Antiseizure Medication-Induced Elevation of Serum Estradiol and Reproductive Dysfunction in Men With Epilepsy
1 other identifier
observational
175
1 country
1
Brief Summary
The purpose of this study is to determine if antiseizure drugs affect hormone levels and sexual function in men with seizures.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Oct 1999
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 1999
CompletedFirst Submitted
Initial submission to the registry
September 12, 2005
CompletedFirst Posted
Study publicly available on registry
September 16, 2005
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2006
CompletedMarch 13, 2017
March 1, 2017
September 12, 2005
March 9, 2017
Conditions
Keywords
Eligibility Criteria
You may qualify if:
- Must be a male between 18-50 years of age
- Must have seizures
- Must be on antiseizure medication for at least six months duration
You may not qualify if:
- Must not have taken hormones, major tranquilizers or antidepressants for at least 3 months
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Beth Israel Deaconess Medical Centerlead
- GlaxoSmithKlinecollaborator
Study Sites (1)
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
Related Publications (1)
Herzog AG, Drislane FW, Schomer DL, Pennell PB, Bromfield EB, Kelly KM, Farina EL, Frye CA. Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men with epilepsy: interim analysis of a comparison between lamotrigine and enzyme-inducing antiepileptic drugs. Epilepsia. 2004 Jul;45(7):764-8. doi: 10.1111/j.0013-9580.2004.60703.x.
PMID: 15230699RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Andrew G. Herzog, M.D., M.Sc.
Beth Israel Deaconess Medical Center
Study Design
- Study Type
- observational
- Time Perspective
- OTHER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Neurology
Study Record Dates
First Submitted
September 12, 2005
First Posted
September 16, 2005
Study Start
October 1, 1999
Study Completion
June 1, 2006
Last Updated
March 13, 2017
Record last verified: 2017-03