Evaluation and Treatment of Patients With Epilepsy

NCT00013845 | Terminated

• 2 other identifiers: 01013901-N-0139
• Study Type: observational
• Target: 1,278
• Locations: 1 country
• Sites: 1

Brief Summary

This protocol has three purposes: 1) to screen patients with seizures for participation in research studies of NINDS s Clinical Epilepsy Section (CES), 2) to follow the natural course of seizure disorders, and 3) to train CES fellows in evaluating and treating epilepsy. Only standard diagnostic tests and treatments will be used in this study. Patients of any age with seizures who are referred to CES may participate in this study. At the end of the study, patients may be discharged to the care of their referring physician, offered participation in another NINDS research protocol, or followed for teaching purposes. Participants will undergo standard diagnostic procedures used to determine the type of their seizures, what part of the brain they are coming from, what is causing them, and whether standard drug treatments can help them. These may include some or all of the following:

• Physical and neurological examination
• Neuropsychological tests tests of learning and memory
• Electroencephalography (EEG) brain wave recording
• Evoked potentials tests of nerve reactions to lights and sounds
• Polysomnography simultaneous recordings of brain waves, breathing and eye movements
• Video-EEG monitoring simultaneous recording of seizures using a video camera and brain waves
• Video-EEG monitoring with extra electrodes to record muscle activity, breathing and eye movements for analyzing sleep patterns
• Imaging studies, such as magnetic resonance imaging (MRI) and positron emission tomography (PET) scans to examine the structure and function of the brain
• Frequent blood tests to measure blood levels of anti-seizure drugs

Conditions

Epilepsy

Keywords

Seizures; Anti-Epileptic Drugs; Pharmacotherapy; Neuropsychology; Temporal Lobe Epilepsy; Frontal Lobe Epilepsy; Complex Partial Seizures; Grand Mal Seizures; Generalized Seizures; Epilepsy

Eligibility Criteria

• Age: 2 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• All patients older than 2 years referred to the Clinical Epilepsy Section will be included. DPA assignment for adults without consent capacity is required at the time of enrollment.

You may not qualify if:

• None.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Baker GA, Nashef L, van Hout BA. Current issues in the management of epilepsy: the impact of frequent seizures on cost of illness, quality of life, and mortality. Epilepsia. 1997;38 Suppl 1:S1-8. doi: 10.1111/j.1528-1157.1997.tb04511.x.

  PMID: 9092951 BACKGROUND

• Begley CE, Famulari M, Annegers JF, Lairson DR, Reynolds TF, Coan S, Dubinsky S, Newmark ME, Leibson C, So EL, Rocca WA. The cost of epilepsy in the United States: an estimate from population-based clinical and survey data. Epilepsia. 2000 Mar;41(3):342-51. doi: 10.1111/j.1528-1157.2000.tb00166.x.

  PMID: 10714408 BACKGROUND

• Hanai T. Quality of life in children with epilepsy. Epilepsia. 1996;37 Suppl 3:28-32. doi: 10.1111/j.1528-1157.1996.tb01816.x.

  PMID: 8681908 BACKGROUND

MeSH Terms

Conditions

Epilepsy; Seizures; Epilepsy, Temporal Lobe; Epilepsy, Frontal Lobe; Epilepsy, Tonic-Clonic

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Epilepsies, Partial; Epileptic Syndromes; Epilepsy, Generalized

Study Officials

• Sara K Inati, M.D.

  National Institute of Neurological Disorders and Stroke (NINDS)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 30, 2001
• First Posted: April 2, 2001
• Study Start: May 1, 2001
• Study Completion: June 26, 2018
• Last Updated: December 12, 2019

Record last verified: 2018-06-26

Locations

US (1)