Reducing Caregiver Stress and Sleep Disturbances in Patients With Progressive Dementia

NCT00178568 | Completed DMC

• 2 other identifiers: 0211171P01AG020677-01
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

People under stress, such as those caring for an ill family member, often have trouble with their sleep. The aim of this study is to see if reducing stress and changing a caregiver's sleep and wake patterns will improve his/her sleep. The investigators also will see whether improvements in sleep result in improved mood, health, and general functioning.

Conditions

Sleep Disorders

Keywords

Caregiving; Spousal; Sleep disturbances; Progressive dementia; Stress; Health outcomes; Intervention; Affective self-management; Caregivers M01.526.485.200; Spouses F01.829.263.500.660; Alzheimer's disease C10.574.945.249; Parkinson's disease C10.574.812; Sleep disorder C10.886.425.800.800

Outcome Measures

Primary Outcomes (1)

• Polysomnography pre and post intervention

  collection of physiological \& psychological variables pre and post BBTI sleep disturbances and stress in caregivers

  18 months

Interventions

Stress Management and Healthy Sleep Practices BEHAVIORAL

Eight weekly sessions of 1 hour each reviewing stress management techniques and tips for improving sleep.

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Males and females over the age of 60 who are primary caregiver for spouse/partner diagnosed with progressive dementia.

You may qualify if:

• Ages 60 or older
• Spousal caregivers of patients with progressive dementia
• Patients have a diagnosis of possible or probable Alzheimer's disease or other progressive dementia
• Affirm that it is a physical and emotional strain to care for spouse
• Pittsburgh Sleep Quality Index score of 5 or above or a polysomnographically determined sleep efficiency of 90% or worse.

You may not qualify if:

• Psychotic disorder or substance abuse disorder
• Apnea-hypopnea index of greater than 30
• Score of less than 24 on Mini-Mental State Exam

Sponsors & Collaborators

• Kathy Kennedy: lead
• National Institute on Aging (NIA): collaborator

Study Sites (1)

University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic

Pittsburgh, Pennsylvania, 15213, United States

Location

Related Publications (88)

• Adler NE, Ostrove JM. Socioeconomic status and health: what we know and what we don't. Ann N Y Acad Sci. 1999;896:3-15. doi: 10.1111/j.1749-6632.1999.tb08101.x.

  PMID: 10681884 BACKGROUND

• Aspinwall LG, Taylor SE. A stitch in time: self-regulation and proactive coping. Psychol Bull. 1997 May;121(3):417-36. doi: 10.1037/0033-2909.121.3.417.

  PMID: 9136643 BACKGROUND

• Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986 Dec;51(6):1173-82. doi: 10.1037//0022-3514.51.6.1173.

  PMID: 3806354 BACKGROUND

• Beharka AA, Meydani M, Wu D, Leka LS, Meydani A, Meydani SN. Interleukin-6 production does not increase with age. J Gerontol A Biol Sci Med Sci. 2001 Feb;56(2):B81-8. doi: 10.1093/gerona/56.2.b81.

  PMID: 11213271 BACKGROUND

• Beneke M. Methodological investigations of the Hamilton Anxiety Scale. Pharmacopsychiatry. 1987 Nov;20(6):249-55. doi: 10.1055/s-2007-1017116.

  PMID: 3432359 BACKGROUND

• Bernstein E, Kaye D, Abrutyn E, Gross P, Dorfman M, Murasko DM. Immune response to influenza vaccination in a large healthy elderly population. Vaccine. 1999 Jan;17(1):82-94. doi: 10.1016/s0264-410x(98)00117-0.

  PMID: 10078611 BACKGROUND

• Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Rein J, Vela-Bueno A, Kales A. Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):608-13. doi: 10.1164/ajrccm.163.3.9911064.

  PMID: 11254512 BACKGROUND

• Bixler EO, Vgontzas AN, Ten Have T, Tyson K, Kales A. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med. 1998 Jan;157(1):144-8. doi: 10.1164/ajrccm.157.1.9706079.

  PMID: 9445292 BACKGROUND

• Brunner DP, Vasko RC, Detka CS, Monahan JP, Reynolds CF 3rd, Kupfer DJ. Muscle artifacts in the sleep EEG: automated detection and effect on all-night EEG power spectra. J Sleep Res. 1996 Sep;5(3):155-64. doi: 10.1046/j.1365-2869.1996.00009.x.

  PMID: 8956205 BACKGROUND

• Burkman RT, Collins JA, Greene RA. Current perspectives on benefits and risks of hormone replacement therapy. Am J Obstet Gynecol. 2001 Aug;185(2 Suppl):S13-23. doi: 10.1067/mob.2001.117414.

  PMID: 11521118 BACKGROUND

• Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989 May;28(2):193-213. doi: 10.1016/0165-1781(89)90047-4.

  PMID: 2748771 BACKGROUND

• Carrier J, Monk TH, Buysse DJ, Kupfer DJ. Sleep and morningness-eveningness in the 'middle' years of life (20-59 y). J Sleep Res. 1997 Dec;6(4):230-7. doi: 10.1111/j.1365-2869.1997.00230.x.

  PMID: 9493522 BACKGROUND

• Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373-83. doi: 10.1016/0021-9681(87)90171-8.

  PMID: 3558716 BACKGROUND

• Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983 Dec;24(4):385-96. No abstract available.

  PMID: 6668417 BACKGROUND

• Coleman RM, Roffwarg HP, Kennedy SJ, Guilleminault C, Cinque J, Cohn MA, Karacan I, Kupfer DJ, Lemmi H, Miles LE, Orr WC, Phillips ER, Roth T, Sassin JF, Schmidt HS, Weitzman ED, Dement WC. Sleep-wake disorders based on a polysomnographic diagnosis. A national cooperative study. JAMA. 1982 Feb 19;247(7):997-1003. No abstract available.

  PMID: 7057593 BACKGROUND

• Dew MA, Hoch CC, Buysse DJ, Monk TH, Begley AE, Houck PR, Hall M, Kupfer DJ, Reynolds CF 3rd. Healthy older adults' sleep predicts all-cause mortality at 4 to 19 years of follow-up. Psychosom Med. 2003 Jan-Feb;65(1):63-73. doi: 10.1097/01.psy.0000039756.23250.7c.

  PMID: 12554816 BACKGROUND

• Dipietro L, Caspersen CJ, Ostfeld AM, Nadel ER. A survey for assessing physical activity among older adults. Med Sci Sports Exerc. 1993 May;25(5):628-42.

  PMID: 8492692 BACKGROUND

• Doman J, Detka C, Hoffman T, Kesicki D, Monahan JP, Buysse DJ, Reynolds CF 3rd, Coble PA, Matzzie J, Kupfer DJ. Automating the sleep laboratory: implementation and validation of digital recording and analysis. Int J Biomed Comput. 1995 Mar;38(3):277-90. doi: 10.1016/s0020-7101(05)80010-8.

  PMID: 7774987 BACKGROUND

• Ershler WB. Interleukin-6: a cytokine for gerontologists. J Am Geriatr Soc. 1993 Feb;41(2):176-81. doi: 10.1111/j.1532-5415.1993.tb02054.x.

  PMID: 8426042 BACKGROUND

• Foley DJ, Monjan AA, Brown SL, Simonsick EM, Wallace RB, Blazer DG. Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep. 1995 Jul;18(6):425-32. doi: 10.1093/sleep/18.6.425.

  PMID: 7481413 BACKGROUND

• Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189-98. doi: 10.1016/0022-3956(75)90026-6. No abstract available.

  PMID: 1202204 BACKGROUND

• Foster JR. Successful coping, adaptation and resilience in the elderly: an interpretation of epidemiologic data. Psychiatr Q. 1997 Fall;68(3):189-219. doi: 10.1023/a:1025432106406.

  PMID: 9237317 BACKGROUND

• Friesen GM, Jannett TC, Jadallah MA, Yates SL, Quint SR, Nagle HT. A comparison of the noise sensitivity of nine QRS detection algorithms. IEEE Trans Biomed Eng. 1990 Jan;37(1):85-98. doi: 10.1109/10.43620.

  PMID: 2303275 BACKGROUND

• Gardner EM, Bernstein ED, Dorfman M, Abrutyn E, Murasko DM. The age-associated decline in immune function of healthy individuals is not related to changes in plasma concentrations of beta-carotene, retinol, alpha-tocopherol or zinc. Mech Ageing Dev. 1997 Mar;94(1-3):55-69. doi: 10.1016/s0047-6374(96)01838-6.

  PMID: 9147360 BACKGROUND

• Gibbon M, McDonald-Scott P, Endicott J. Mastering the art of research interviewing. A model training procedure for diagnostic evaluation. Arch Gen Psychiatry. 1981 Nov;38(11):1259-62. doi: 10.1001/archpsyc.1981.01780360075007.

  PMID: 7305606 BACKGROUND

• Gibson EL, Checkley S, Papadopoulos A, Poon L, Daley S, Wardle J. Increased salivary cortisol reliably induced by a protein-rich midday meal. Psychosom Med. 1999 Mar-Apr;61(2):214-24. doi: 10.1097/00006842-199903000-00014.

  PMID: 10204975 BACKGROUND

• Glaser R, Kiecolt-Glaser JK, Bonneau RH, Malarkey W, Kennedy S, Hughes J. Stress-induced modulation of the immune response to recombinant hepatitis B vaccine. Psychosom Med. 1992 Jan-Feb;54(1):22-9. doi: 10.1097/00006842-199201000-00005.

  PMID: 1553399 BACKGROUND

• Gurland BJ, Wilder DE. The CARE interview revisited: development of an efficient, systematic clinical assessment. J Gerontol. 1984 Mar;39(2):129-37. doi: 10.1093/geronj/39.2.129.

  PMID: 6699366 BACKGROUND

• HAMILTON M. The assessment of anxiety states by rating. Br J Med Psychol. 1959;32(1):50-5. doi: 10.1111/j.2044-8341.1959.tb00467.x. No abstract available.

  PMID: 13638508 BACKGROUND

• HAMILTON M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960 Feb;23(1):56-62. doi: 10.1136/jnnp.23.1.56. No abstract available.

  PMID: 14399272 BACKGROUND

• Horne JA, Ostberg O. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int J Chronobiol. 1976;4(2):97-110.

  PMID: 1027738 BACKGROUND

• Janssens JP, Pautex S, Hilleret H, Michel JP. Sleep disordered breathing in the elderly. Aging (Milano). 2000 Dec;12(6):417-29. doi: 10.1007/BF03339872.

  PMID: 11211951 BACKGROUND

• Jenkins CD, Kreger BE, Rose RM, Hurst M. Use of a monthly health review to ascertain illness and injuries. Am J Public Health. 1980 Jan;70(1):82-4. doi: 10.2105/ajph.70.1.82.

  PMID: 6965340 BACKGROUND

• Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991 Dec;14(6):540-5. doi: 10.1093/sleep/14.6.540.

  PMID: 1798888 BACKGROUND

• Johns MW. Reliability and factor analysis of the Epworth Sleepiness Scale. Sleep. 1992 Aug;15(4):376-81. doi: 10.1093/sleep/15.4.376.

  PMID: 1519015 BACKGROUND

• Johns MW. Daytime sleepiness, snoring, and obstructive sleep apnea. The Epworth Sleepiness Scale. Chest. 1993 Jan;103(1):30-6. doi: 10.1378/chest.103.1.30.

  PMID: 8417909 BACKGROUND

• Kania DM, Binkley N, Checovich M, Havighurst T, Schilling M, Ershler WB. Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density. J Am Geriatr Soc. 1995 Mar;43(3):236-9. doi: 10.1111/j.1532-5415.1995.tb07328.x.

  PMID: 7884109 BACKGROUND

• Katz DA, McHorney CA. Clinical correlates of insomnia in patients with chronic illness. Arch Intern Med. 1998 May 25;158(10):1099-107. doi: 10.1001/archinte.158.10.1099.

  PMID: 9605781 BACKGROUND

• Katz JN, Chang LC, Sangha O, Fossel AH, Bates DW. Can comorbidity be measured by questionnaire rather than medical record review? Med Care. 1996 Jan;34(1):73-84. doi: 10.1097/00005650-199601000-00006.

  PMID: 8551813 BACKGROUND

• Kawachi I, Berkman LF. Social ties and mental health. J Urban Health. 2001 Sep;78(3):458-67. doi: 10.1093/jurban/78.3.458.

  PMID: 11564849 BACKGROUND

• Kiecolt-Glaser JK, Dura JR, Speicher CE, Trask OJ, Glaser R. Spousal caregivers of dementia victims: longitudinal changes in immunity and health. Psychosom Med. 1991 Jul-Aug;53(4):345-62. doi: 10.1097/00006842-199107000-00001.

  PMID: 1656478 BACKGROUND

• Kiecolt-Glaser JK, Marucha PT, Malarkey WB, Mercado AM, Glaser R. Slowing of wound healing by psychological stress. Lancet. 1995 Nov 4;346(8984):1194-6. doi: 10.1016/s0140-6736(95)92899-5.

  PMID: 7475659 BACKGROUND

• Kirschbaum C, Hellhammer DH. Salivary cortisol in psychoneuroendocrine research: recent developments and applications. Psychoneuroendocrinology. 1994;19(4):313-33. doi: 10.1016/0306-4530(94)90013-2.

  PMID: 8047637 BACKGROUND

• Kirschbaum C, Kudielka BM, Gaab J, Schommer NC, Hellhammer DH. Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis. Psychosom Med. 1999 Mar-Apr;61(2):154-62. doi: 10.1097/00006842-199903000-00006.

  PMID: 10204967 BACKGROUND

• Kramer M. Hypnotic medication in the treatment of chronic insomnia: non nocere! Doesn't anyone care? Sleep Med Rev. 2000 Dec;4(6):529-541. doi: 10.1053/smrv.2000.0122.

  PMID: 12531035 BACKGROUND

• Krueger JM, Obal F Jr, Fang J. Humoral regulation of physiological sleep: cytokines and GHRH. J Sleep Res. 1999 Jun;8 Suppl 1:53-9. doi: 10.1046/j.1365-2869.1999.00009.x.

  PMID: 10389107 BACKGROUND

• Kudielka BM, Schmidt-Reinwald AK, Hellhammer DH, Kirschbaum C. Psychological and endocrine responses to psychosocial stress and dexamethasone/corticotropin-releasing hormone in healthy postmenopausal women and young controls: the impact of age and a two-week estradiol treatment. Neuroendocrinology. 1999 Dec;70(6):422-30. doi: 10.1159/000054504.

  PMID: 10657735 BACKGROUND

• Kudielka BM, Schmidt-Reinwald AK, Hellhammer DH, Schurmeyer T, Kirschbaum C. Psychosocial stress and HPA functioning: no evidence for a reduced resilience in healthy elderly men. Stress. 2000 May;3(3):229-40. doi: 10.3109/10253890009001127.

  PMID: 10938584 BACKGROUND

• Lacks P, Rotert M. Knowledge and practice of sleep hygiene techniques in insomniacs and good sleepers. Behav Res Ther. 1986;24(3):365-8. doi: 10.1016/0005-7967(86)90197-x. No abstract available.

  PMID: 3729908 BACKGROUND

• Magnano CL, Diamond EJ, Gardner JM. Use of salivary cortisol measurements in young infants: a note of caution. Child Dev. 1989 Oct;60(5):1099-101.

  PMID: 2805888 BACKGROUND

• McHorney CA, Ware JE Jr, Raczek AE. The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care. 1993 Mar;31(3):247-63. doi: 10.1097/00005650-199303000-00006.

  PMID: 8450681 BACKGROUND

• Miller MD, Paradis CF, Houck PR, Mazumdar S, Stack JA, Rifai AH, Mulsant B, Reynolds CF 3rd. Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale. Psychiatry Res. 1992 Mar;41(3):237-48. doi: 10.1016/0165-1781(92)90005-n.

  PMID: 1594710 BACKGROUND

• Monk TH, Buysse DJ, Rose LR. Wrist actigraphic measures of sleep in space. Sleep. 1999 Nov 1;22(7):948-54.

  PMID: 10566913 BACKGROUND

• Monk TH, Flaherty JF, Frank E, Hoskinson K, Kupfer DJ. The Social Rhythm Metric. An instrument to quantify the daily rhythms of life. J Nerv Ment Dis. 1990 Feb;178(2):120-6. doi: 10.1097/00005053-199002000-00007.

  PMID: 2299336 BACKGROUND

• Monk TH, Petrie SR, Hayes AJ, Kupfer DJ. Regularity of daily life in relation to personality, age, gender, sleep quality and circadian rhythms. J Sleep Res. 1994 Dec;3(4):196-205. doi: 10.1111/j.1365-2869.1994.tb00132.x.

  PMID: 10607126 BACKGROUND

• Monk TH, Reynolds CF 3rd, Kupfer DJ, Buysse DJ, Coble PA, Hayes AJ, Machen MA, Petrie SR, Ritenour AM. The Pittsburgh Sleep Diary. J Sleep Res. 1994;3:111-20.

  PMID: 11537903 BACKGROUND

• Monk TH, Reynolds CF, Kupfer DJ, Buysse DJ, Coble PA, Hayes AJ, MacHen MA, Petrie SR, Ritenour AM. The Pittsburgh Sleep Diary. J Sleep Res. 1994 Jun;3(2):111-120.

  PMID: 10607115 BACKGROUND

• Murasko DM, Nelson BJ, Matour D, Goonewardene IM, Kaye D. Heterogeneity of changes in lymphoproliferative ability with increasing age. Exp Gerontol. 1991;26(2-3):269-79. doi: 10.1016/0531-5565(91)90020-m.

  PMID: 1915696 BACKGROUND

• Murasko DM, Weiner P, Kaye D. Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin Exp Immunol. 1987 Nov;70(2):440-8.

  PMID: 3427828 BACKGROUND

• Newman AB, Enright PL, Manolio TA, Haponik EF, Wahl PW. Sleep disturbance, psychosocial correlates, and cardiovascular disease in 5201 older adults: the Cardiovascular Health Study. J Am Geriatr Soc. 1997 Jan;45(1):1-7. doi: 10.1111/j.1532-5415.1997.tb00970.x.

  PMID: 8994480 BACKGROUND

• Nowell PD, Buysse DJ, Reynolds CF 3rd, Hauri PJ, Roth T, Stepanski EJ, Thorpy MJ, Bixler E, Kales A, Manfredi RL, Vgontzas AN, Stapf DM, Houck PR, Kupfer DJ. Clinical factors contributing to the differential diagnosis of primary insomnia and insomnia related to mental disorders. Am J Psychiatry. 1997 Oct;154(10):1412-6. doi: 10.1176/ajp.154.10.1412.

  PMID: 9326824 BACKGROUND

• Nowell PD, Mazumdar S, Buysse DJ, Dew MA, Reynolds CF 3rd, Kupfer DJ. Benzodiazepines and zolpidem for chronic insomnia: a meta-analysis of treatment efficacy. JAMA. 1997 Dec 24-31;278(24):2170-7.

  PMID: 9417012 BACKGROUND

• Ockenfels MC, Porter L, Smyth J, Kirschbaum C, Hellhammer DH, Stone AA. Effect of chronic stress associated with unemployment on salivary cortisol: overall cortisol levels, diurnal rhythm, and acute stress reactivity. Psychosom Med. 1995 Sep-Oct;57(5):460-7. doi: 10.1097/00006842-199509000-00008.

  PMID: 8552737 BACKGROUND

• Ostrove JM, Adler NE, Kuppermann M, Washington AE. Objective and subjective assessments of socioeconomic status and their relationship to self-rated health in an ethnically diverse sample of pregnant women. Health Psychol. 2000 Nov;19(6):613-8. doi: 10.1037//0278-6133.19.6.613.

  PMID: 11129365 BACKGROUND

• Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell'Orto S, Piccaluga E, et al. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res. 1986 Aug;59(2):178-93. doi: 10.1161/01.res.59.2.178.

  PMID: 2874900 BACKGROUND

• Pilcher JJ, Bergmann BM, Refetoff S, Fang VS, Rechtschaffen A. Sleep deprivation in the rat: XIII. The effect of hypothyroidism on sleep deprivation symptoms. Sleep. 1991 Jun;14(3):201-10. doi: 10.1093/sleep/14.3.201.

  PMID: 1896721 BACKGROUND

• Pilcher JJ, Huffcutt AI. Effects of sleep deprivation on performance: a meta-analysis. Sleep. 1996 May;19(4):318-26. doi: 10.1093/sleep/19.4.318.

  PMID: 8776790 BACKGROUND

• Prinz PN, Bailey SL, Woods DL. Sleep impairments in healthy seniors: roles of stress, cortisol, and interleukin-1 beta. Chronobiol Int. 2000 May;17(3):391-404. doi: 10.1081/cbi-100101053.

  PMID: 10841212 BACKGROUND

• Redwine L, Hauger RL, Gillin JC, Irwin M. Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. J Clin Endocrinol Metab. 2000 Oct;85(10):3597-603. doi: 10.1210/jcem.85.10.6871.

  PMID: 11061508 BACKGROUND

• Rogers NL, Szuba MP, Staab JP, Evans DL, Dinges DF. Neuroimmunologic aspects of sleep and sleep loss. Semin Clin Neuropsychiatry. 2001 Oct;6(4):295-307. doi: 10.1053/scnp.2001.27907.

  PMID: 11607924 BACKGROUND

• Russo J, Vitaliano PP. Life events as correlates of burden in spouse caregivers of persons with Alzheimer's disease. Exp Aging Res. 1995 Jul-Sep;21(3):273-94. doi: 10.1080/03610739508253985.

  PMID: 7493596 BACKGROUND

• Scheier MF, Bridges MW. Person variables and health: personality predispositions and acute psychological states as shared determinants for disease. Psychosom Med. 1995 May-Jun;57(3):255-68. doi: 10.1097/00006842-199505000-00007.

  PMID: 7652126 BACKGROUND

• Schein OD, Hochberg MC, Munoz B, Tielsch JM, Bandeen-Roche K, Provost T, Anhalt GJ, West S. Dry eye and dry mouth in the elderly: a population-based assessment. Arch Intern Med. 1999 Jun 28;159(12):1359-63. doi: 10.1001/archinte.159.12.1359.

  PMID: 10386512 BACKGROUND

• Schramm E, Hohagen F, Grasshoff U, Riemann D, Hajak G, Weess HG, Berger M. Test-retest reliability and validity of the Structured Interview for Sleep Disorders According to DSM-III-R. Am J Psychiatry. 1993 Jun;150(6):867-72. doi: 10.1176/ajp.150.6.867.

  PMID: 8494060 BACKGROUND

• Shearer WT, Reuben JM, Mullington JM, Price NJ, Lee BN, Smith EO, Szuba MP, Van Dongen HP, Dinges DF. Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J Allergy Clin Immunol. 2001 Jan;107(1):165-70. doi: 10.1067/mai.2001.112270.

  PMID: 11150007 BACKGROUND

• Smith CS, Reilly C, Midkiff K. Evaluation of three circadian rhythm questionnaires with suggestions for an improved measure of morningness. J Appl Psychol. 1989 Oct;74(5):728-38. doi: 10.1037/0021-9010.74.5.728.

  PMID: 2793773 BACKGROUND

• Smyth J, Ockenfels MC, Porter L, Kirschbaum C, Hellhammer DH, Stone AA. Stressors and mood measured on a momentary basis are associated with salivary cortisol secretion. Psychoneuroendocrinology. 1998 May;23(4):353-70. doi: 10.1016/s0306-4530(98)00008-0.

  PMID: 9695136 BACKGROUND

• Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet. 1999 Oct 23;354(9188):1435-9. doi: 10.1016/S0140-6736(99)01376-8.

  PMID: 10543671 BACKGROUND

• Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA. 1999 Nov 10;282(18):1737-44. doi: 10.1001/jama.282.18.1737.

  PMID: 10568646 BACKGROUND

• Vasko RC Jr, Brunner DP, Monahan JP, Doman J, Boston JR, el-Jaroudi A, Miewald J, Buysse DJ, Reynolds CF 3rd, Kupfer DJ. Power spectral analysis of EEG in a multiple-bedroom, multiple-polygraph sleep laboratory. Int J Med Inform. 1997 Oct;46(3):175-84. doi: 10.1016/s1386-5056(97)00064-6.

  PMID: 9373779 BACKGROUND

• Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Tyson K, Chrousos GP. Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J Clin Endocrinol Metab. 1997 May;82(5):1313-6. doi: 10.1210/jcem.82.5.3950.

  PMID: 9141509 BACKGROUND

• Vgontzas AN, Papanicolaou DA, Bixler EO, Lotsikas A, Zachman K, Kales A, Prolo P, Wong ML, Licinio J, Gold PW, Hermida RC, Mastorakos G, Chrousos GP. Circadian interleukin-6 secretion and quantity and depth of sleep. J Clin Endocrinol Metab. 1999 Aug;84(8):2603-7. doi: 10.1210/jcem.84.8.5894.

  PMID: 10443646 BACKGROUND

• Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992 Jun;30(6):473-83.

  PMID: 1593914 BACKGROUND

• Wedzicha JA. Mechanisms of exacerbations. Novartis Found Symp. 2001;234:84-93; discussion 93-103. doi: 10.1002/0470868678.ch6.

  PMID: 11199105 BACKGROUND

• Williamson GM, Shaffer DR. Relationship quality and potentially harmful behaviors by spousal caregivers: how we were then, how we are now. The Family Relationships in Late Life Project. Psychol Aging. 2001 Jun;16(2):217-26.

  PMID: 11405310 BACKGROUND

• Wust S, Federenko I, Hellhammer DH, Kirschbaum C. Genetic factors, perceived chronic stress, and the free cortisol response to awakening. Psychoneuroendocrinology. 2000 Oct;25(7):707-20. doi: 10.1016/s0306-4530(00)00021-4.

  PMID: 10938450 BACKGROUND

• Zetterberg LH. A mathematical model for analysis of EEG. Electroencephalogr Clin Neurophysiol. 1969 Mar;26(3):338. No abstract available.

  PMID: 4183459 BACKGROUND

• Callan JA, Siegle GJ, Abebe K, Black B, Martire L, Schulz R, Reynolds C 3rd, Hall MH. Feasibility of a pocket-PC based cognitive control intervention in dementia spousal caregivers. Aging Ment Health. 2016;20(6):575-82. doi: 10.1080/13607863.2015.1031635. Epub 2015 May 6.

  PMID: 25945597 DERIVED

Related Links

• University of Pittsburgh Institute on Aging

Biospecimen

Retention: SAMPLES WITHOUT DNA

Saliva collected on cotton rolls and frozen by participant. Kept frozen until shipped for assay.

MeSH Terms

Conditions

Sleep Wake Disorders; Parasomnias; Alzheimer Disease

Condition Hierarchy (Ancestors)

Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders; Dementia; Brain Diseases; Central Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders

Study Officials

• Martica Hall, Ph.D.

  University of Pittsburgh Medical Center

  PRINCIPAL INVESTIGATOR

• Lynn Martire, Ph.D.

  University of Pittsburgh Medical Center

  STUDY DIRECTOR

• Greg Seigel, Ph.D.

  University of Pittsburgh Medical Center

  STUDY DIRECTOR

• Richard Schulz, Ph.D.

  University of Pittsburgh Medical Center

  STUDY DIRECTOR

• Charles F. Reynolds, III, M.D.

  University of Pittsburgh Medical Center

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Research Program Administrator

Study Record Dates

• First Submitted: September 13, 2005
• First Posted: September 15, 2005
• Study Start: February 1, 2003
• Primary Completion: November 1, 2008
• Study Completion: November 1, 2009
• Last Updated: May 28, 2015

Record last verified: 2015-05

Locations

US (1)