Circadian Regulation of Sleep in Habitual Short Sleepers and Long Sleepers

NCT00001546 | Completed

• 2 other identifiers: 96008796-M-0087
• Study Type: observational
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

Routine sleep duration varies greatly among individuals. The biological meaning of this variation is unknown. The term circadian rhythm refers to the biological clock that regulates the timing of falling asleep, waking up, and secretion of hormones, like melatonin. Melatonin is secreted at night. Previous studies have shown that melatonin may play a role in the regulation of sleep. The purpose of this study is to learn whether the duration of nighttime (nocturnal) melatonin secretion is longer in people with long regular sleep duration than people with short sleep duration. Researchers will compare levels of melatonin and cortisol, body temperature, sleepiness, and sleep in two extreme groups. Group one will be made up of people with short sleep duration lasting less than 6 hours. Group two will be made up of people with long sleep duration lasting more than 9 hours.

Conditions

Sleep Disorders

Keywords

Biochemical Screening; Body Temperature; Consent Form; EEG; EKG; Melatonin; Mood; Physical Examination; Psychiatric Examination; Sleep Duration; Sleep Disorders

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Sleep greater than or equal to 9 hours almost every night. Sleep less than or equal to 6 hours almost every night. Between ages 20-30. No medications, history of psychiatric illness, history of head injury. No sleep disturbances.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (1)

National Institute of Mental Health (NIMH)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Borbely AA. A two process model of sleep regulation. Hum Neurobiol. 1982;1(3):195-204. No abstract available.

  PMID: 7185792 BACKGROUND

• Aeschbach D, Cajochen C, Landolt H, Borbely AA. Homeostatic sleep regulation in habitual short sleepers and long sleepers. Am J Physiol. 1996 Jan;270(1 Pt 2):R41-53. doi: 10.1152/ajpregu.1996.270.1.R41.

  PMID: 8769783 BACKGROUND

• Borbely AA, Baumann F, Brandeis D, Strauch I, Lehmann D. Sleep deprivation: effect on sleep stages and EEG power density in man. Electroencephalogr Clin Neurophysiol. 1981 May;51(5):483-95. doi: 10.1016/0013-4694(81)90225-x.

  PMID: 6165548 BACKGROUND

MeSH Terms

Conditions

Sleep Wake Disorders

Condition Hierarchy (Ancestors)

Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: December 10, 2002
• Study Start: May 1, 1996
• Study Completion: June 1, 2000
• Last Updated: March 4, 2008

Record last verified: 1999-04

Locations

US (1)